Dihydroartemisinin (DHA) - CAS 71939-50-9
Catalog number: 71939-50-9
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C15H24O5
Molecular Weight:
284.35
COA:
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Targets:
Others
Description:
Dihydroartemisinin (DHA) is a semi-synthetic derivative of artemisinin and isolated from the traditional Chinese herb Artemisia annua.
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Purity:
>98%
Synonyms:
SM-224, CGP 56696
MSDS:
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1.Dihydroartemisinin attenuates lipopolysaccharide-induced osteoclastogenesis and bone loss via the mitochondria-dependent apoptosis pathway.
Dou C1,2, Ding N1, Xing J1, Zhao C2, Kang F2, Hou T1, Quan H2, Chen Y2, Dai Q1, Luo F1, Xu J1, Dong S2,3. Cell Death Dis. 2016 Mar 31;7:e2162. doi: 10.1038/cddis.2016.69.
Dihydroartemisinin (DHA) is a widely used antimalarial drug isolated from the plant Artemisia annua. Recent studies suggested that DHA has antitumor effects utilizing its reactive oxygen species (ROS) yielding mechanism. Here, we reported that DHA is inhibitory on lipopolysaccharide (LPS)-induced osteoclast (OC) differentiation, fusion and bone-resorption activity in vitro. Intracellular ROS detection revealed that DHA could remarkably increase ROS accumulation during LPS-induced osteoclastogenesis. Moreover, cell apoptosis was also increased by DHA treatment. We found that DHA-activated caspase-3 increased Bax/Bcl-2 ratio during LPS-induced osteoclastogenesis. Meanwhile, the translocation of apoptotic inducing factor (AIF) and the release of cytochrome c from the mitochondria into the cytosol were observed, indicating that ROS-mediated mitochondrial dysfunction is crucial in DHA-induced apoptosis during LPS-induced osteoclastogenesis. In vivo study showed that DHA treatment decreased OC number, prevents bone loss, rescues bone microarchitecture and restores bone strength in LPS-induced bone-loss mouse model.
2.Dihydroartemisinin inhibits cell proliferation by induced G1 arrest and apoptosis in human nasopharyngealcarcinoma cells.
Huang Z, Huang X, Jiang D, Zhang Y, Huang B, Luo G1. J Cancer Res Ther. 2016 Jan-Mar;12(1):244-7. doi: 10.4103/0973-1482.151855.
CONTEXT: Dihydroartemisinin (DHA) exhibits anticancer activity in a number of human cancer cells. However, it is still unknown whether DHA has anticancer effect on nasopharyngeal cancer (NPC) cells.
3.Dihydroartemisinin alleviates bile duct ligation-induced liver fibrosis and hepatic stellate cell activation by interfering with the PDGF-βR/ERK signaling pathway.
Chen Q1, Chen L1, Kong D2, Shao J1, Wu L1, Zheng S3. Int Immunopharmacol. 2016 May;34:250-8. doi: 10.1016/j.intimp.2016.03.011.
Liver fibrosis represents a frequent event following chronic insult to trigger wound healing responses in the liver. Activation of hepatic stellate cells (HSCs), which is a pivotal event during liver fibrogenesis, is accompanied by enhanced expressions of a series of marker proteins and pro-fibrogenic signaling molecules. Artemisinin, a powerful antimalarial medicine, is extracted from the Chinese herb Artemisia annua L., and can inhibit the proliferation of cancer cells. Dihydroartemisinin (DHA), the major active metabolite of artemisinin, is able to attenuate lung injury and fibrosis. However, the effect of DHA on liver fibrosis remains unclear. The aim of this study was to investigate the effect of DHA on bile duct ligation-induced injury and fibrosis in rats. DHA improved the liver histological architecture and attenuated collagen deposition in the fibrotic rat liver. Experiments in vitro showed that DHA inhibited the proliferation of HSCs and arrested the cell cycle at the S checkpoint by altering several cell-cycle regulatory proteins.
4.Dihydroartemisinin inhibits cell proliferation by induced G1 arrest and apoptosis in human nasopharyngealcarcinoma cells.
Huang Z, Huang X, Jiang D, Zhang Y, Huang B, Luo G1. J Cancer Res Ther. 2016 Jan-Mar;12(1):244-7. doi: 10.4103/0973-1482.151855.
CONTEXT: Dihydroartemisinin (DHA) exhibits anticancer activity in a number of human cancer cells. However, it is still unknown whether DHA has anticancer effect on nasopharyngeal cancer (NPC) cells.
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CAS 71939-50-9 Dihydroartemisinin (DHA)

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