Diflorasone Diacetate - CAS 33564-31-7
Category: Inhibitor
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Molecular Formula:
C26H32F2O7
Molecular Weight:
494.52
COA:
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Targets:
Others
Description:
Diflorasone Diacetate is a salt of diflorasone, which is a corticosteroid used as anti-inflammatory and anti-itching agent in the topical creams. Diflorasone inhibits the production of the inflammatory cytokines Il-6, Il-4, and macrophage inflammatory protein-2 (Mip-2), and alleviates swelling in the ears of toluene-2,4-diisocyaniate-sensitized mice.
Brife Description:
corticosteroid, anti-inflammatory and anti-itching agent
Purity:
99%
Related CAS:
2557-49-5 (free base)
Appearance:
White to Off-White Solid
Synonyms:
Psorcon; Florone E; Maxiflor; Apexicon e
MSDS:
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Application:
anti-inflammatory agent
Melting Point:
220-226ºC
InChIKey:
BOBLHFUVNSFZPJ-JOYXJVLSSA-N
InChI:
InChI=1S/C26H32F2O7/c1-13-8-17-18-10-20(27)19-9-16(31)6-7-23(19,4)25(18,28)21(32)11-24(17,5)26(13,35-15(3)30)22(33)12-34-14(2)29/h6-7,9,13,17-18,20-21,32H,8,10-12H2,1-5H3/t13-,17-,18-,20-,21-,23-,24-,25-,26-/m0/s1
Canonical SMILES:
CC1CC2C3CC(C4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)COC(=O)C)OC(=O)C)C)O)F)C)F
1.A clinical evaluation of tazarotene 0.1% gel, with and without a high- or mid-high-potency corticosteroid, in patients with stable plaque psoriasis.
Green L;Sadoff W J Cutan Med Surg. 2002 Mar-Apr;6(2):95-102. Epub 2002 Feb 13.
BACKGROUND: ;Several clinical trials have established the benefit of using a topical corticosteroid in conjunction with tazarotene gel in the treatment of plaque psoriasis. However, there is little information comparing the relative benefits of different corticosteroids, or different formulations of corticosteroids, when used adjunctively with tazarotene.;OBJECTIVE: ;This study was designed to compare the clinical benefits achieved with each of six commonly prescribed high- or mid-high-potency corticosteroid creams and ointments applied in conjunction with tazarotene 0.1% gel in the treatment of patients with stable plaque psoriasis.;METHODS: ;A 12-week, multicenter, investigator-masked, randomized, parallel-group study was performed with more than 200 patients who were randomly assigned to regimens of tazarotene 0.1% gel alone, tazarotene plus a high-potency topical corticosteroid (fluocinonide 0.05% ointment, mometasone furoate 0.1% ointment, or diflorasone diacetate 0.05% ointment), or tazarotene plus a mid-high-potency topical corticosteroid (betamethasone dipropionate 0.05% cream, fluticasone propionate 0.005% ointment, or diflorasone diacetate 0.05% cream). All medications were to be applied once daily: corticosteroids in the morning, tazarotene gel in the evening.
2.Effects of polyoxypropylene 15 stearyl ether and propylene glycol on percutaneous penetration rate of diflorasone diacetate.
Turi JS;Danielson D;Woltersom JW J Pharm Sci. 1979 Mar;68(3):275-80.
Theoretical models for percutaneous penetration are described, and a diffusion apparatus useful in the evaluation of transport kinetics of drugs applied to skin is discussed. Experimental data are presented for: (a) the flux of diflorasone diacetate through hairless mouse skin, (b) the percutaneous penetration profile of propylene glycol, (c) the effects of vehicle concentrations of polyoxypropylene 15 stearyl ether and propylene glycol on the percutaneous flux of diflorasone diacetate, (d) skin--vehicle partition coefficients of diflorasone diacetate, (e) the solubility profile of diflorasone diacetate as a function of solvent concentration, and (f) the alteration of the skin's resistance to the penetration of diflorasone diacetate due to propylene glycol. Excess solvent in a vehicle caused a decrease in the percutaneous flux of diflorasone diacetate. Formulations containing 0.05 and 0.1% diflorasone diacetate had similar penetration rates when the solvent concentration was optimized for each percentage of diflorasone diacetate.
3.Once-daily treatment of psoriasis with topical glucocorticosteroid ointments.
Lane AT;Wachs GN;Weston WL J Am Acad Dermatol. 1983 Apr;8(4):523-5.
A double-blind, vehicle-controlled comparison of two glucocorticosteroid ointments demonstrated that once-daily therapy for psoriasis was effective. After 3 weeks of once-daily therapy, psoriasis subjects treated with betamethasone dipropionate (BD) ointment or diflorasone diacetate (DD) ointment showed statistically significant (p less than 0.01) improvement compared to subjects using vehicle alone.
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CAS 33564-31-7 Diflorasone Diacetate

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