Diethylstilbestrol - CAS 56-53-1
Catalog number: 56-53-1
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Estrogen Receptor/ERR
Diethylstilbestrol, a synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders.
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1.Prenatal diethylstilbestrol exposure and high-grade squamous cell neoplasia of the lower genital tract.
Troisi R1, Hatch EE2, Palmer JR3, Titus L4, Robboy SJ5, Strohsnitter WC6, Herbst AL7, Adam E8, Hyer M9, Hoover RN10. Am J Obstet Gynecol. 2016 Mar 12. pii: S0002-9378(16)00469-5. doi: 10.1016/j.ajog.2016.03.007. [Epub ahead of print]
BACKGROUND: Prenatal diethylstilbestrol (DES) exposure is associated with an excess risk of clear-cell adenocarcinoma of the vagina and cervix, and of high-grade squamous neoplasia.
2.[Rapid detection of diethylstilbestrol using a quartz crystal microbalance with gold nanoparticals amplification].
Liu XY1, Peng Y, Bai JL, Qie ZW, Ning BA, Gao ZX. Zhonghua Yu Fang Yi Xue Za Zhi. 2016 Mar 6;50(3):270-3. doi: 10.3760/cma.j.issn.0253-9624.2016.03.016.
OBJECTIVE: To develop a quartz crystal microbalance (QCM) immunosensor with high sensitivity and selectivity for the rapid detection of diethylstilbestrol.
3.Low-dose and combined effects of oral exposure to bisphenol A and diethylstilbestrol on the male reproductive system in adult Sprague-Dawley rats.
Jiang X1, Chen HQ1, Cui ZH1, Yin L1, Zhang WL1, Liu WB1, Han F1, Ao L1, Cao J1, Liu JY2. Environ Toxicol Pharmacol. 2016 Feb 24;43:94-102. doi: 10.1016/j.etap.2016.02.014. [Epub ahead of print]
Study of the joint action of xenobiotics is important to fully explore their toxicity and complete risk analysis. In this study, we investigated the effects of low-dose and combined exposure of bisphenol A (BPA) and diethylstilbestrol (DES) on the reproductive system in adult male rats. The results showed that the sperm motility decreased in the BPA/DES and combined groups. Sperm deformity ratios and histological lesions of the testes were significantly higher and more significant, respectively, in the combined group compared with the single treated groups. No dose-effect relationship or significant additive effect on serum hormone levels was observed after combined exposure to BPA/DES. Ultrastructural results showed lesions of the Sertoli and Leydig cells, mainly in the endoplasmic reticulum (ER), in all treated groups. ER stress molecular sensor IRE1 was phosphorylated and activated after BPA and DES treatment in this study. The protein levels of ES stress molecular marker CHOP were significantly up-regulated after exposure to BPA, DES, and BPA and DES combined.
4.Occurrence and removal of phenolic endocrine disrupting chemicals in the water treatment processes.
Lv X1, Xiao S1, Zhang G1, Jiang P1, Tang F1. Sci Rep. 2016 Mar 8;6:22860. doi: 10.1038/srep22860.
This paper evaluated the occurrence and removal efficiency of four selected phenolic endocrine disrupting chemicals (bisphenol A (BPA), octylphenol (OP), nonylphenol (NP) and diethylstilbestrol (DES)) in two drinking waterworks in Jiangsu province which take source water from Taihu Lake. The recombined yeast estrogen screen (YES) and liquid chromatography tandem mass spectrometry (LC-MS/MS) were applied to assess the estrogenicity and detect the estrogens in the samples. The estrogen equivalents (EEQs) ranged from nd (not detected) to 2.96 ng/L, and the estrogenic activities decreased along the processes. Among the 32 samples, DES prevailed in all samples, with concentrations ranging 1.46-12.0 ng/L, BPA, OP and NP were partially detected, with concentrations ranging from nd to 17.73 ng/L, nd to 0.49 ng/L and nd to 3.27 ng/L, respectively. DES was found to be the main contributor to the estrogenicity (99.06%), followed by NP (0.62%), OP (0.
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CAS 56-53-1 Diethylstilbestrol

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