Dienestrol - CAS 84-17-3
Catalog number:
84-17-3
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C18H18O2
Molecular Weight:
266.33
COA:
Inquire
Targets:
Others
Description:
Dienestrol is a synthetic and non-steroidal estrogen, which structurally related to stilbestrol. It is an estrogen receptor agonist and a metabolite of Diethylstilbestrol. It is used in the treatment of menopausal and postmenopausal symptoms.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
Appearance:
Light yellow to yellow Solid
Synonyms:
Dehydrostilbestrol;Cycladiene;Follidiene;4-[(2E,4E)-4-(4-hydroxyphenyl)hexa-2,4-dien-3-yl]phenol;2,4-Hexadiene,3,4-bis(4-hydroxyphenyl)-;3,4-Bis(p-hydroxyphenyl)-2,4-hexadiene;3,4-Di-p-(hydroxyphenyl)hexa-2,4-diene;4,4'-(Diethylideneethylene)diphenol;4,4'-Dihydroxy-g,d-diphenyl-b,d-hexadiene;Di-(p-oxyphenyl)-2,4-hexadiene;Estrodienol;Gynefollin;Hormofemin;Sexadien;Synestrol;Teserene;p,p'-(Diethylideneethylene)diphenol
Solubility:
10 mM in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
Dienestrol is used in the treatment of menopausal and postmenopausal symptoms.
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Grams-Kilos
Boiling Point:
395.4±22.0 °C | Condition: Press: 760 Torr
Melting Point:
227-228 °C
Density:
1.184 g/cm3
InChIKey:
NFDFQCUYFHCNBW-SCGPFSFSSA-N
InChI:
InChI=1S/C18H18O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h3-12,19-20H,1-2H3/b17-3+,18-4+
Canonical SMILES:
CC=C(C1=CC=C(C=C1)O)C(=CC)C2=CC=C(C=C2)O
Current Developer:
Dienestrol has been listed.
1.Monitoring of selected estrogen mimics in complicated samples using polymeric ionic liquid-based multiple monolithic fiber solid-phase microextraction combined with high-performance liquid chromatography.
Mei M1, Yu J1, Huang X2, Li H1, Lin L1, Yuan D1. J Chromatogr A. 2015 Mar 13;1385:12-9. doi: 10.1016/j.chroma.2015.01.072. Epub 2015 Feb 2.
A convenient, rapid, sensitive and environmentally friendly method for simultaneous monitoring of six estrogen mimics (bisphenol A, diethylstilbestrol, dienestrol, hexestrol, octylphenol and nonylphenol) in water and milk samples was developed by coupling multiple monolithic fiber solid-phase microextraction (MMF-SPME) to high performance liquid chromatography with diode array detection. The MMF-SPME based on polymeric ionic liquid-based monolith as extractive medium was used to concentrate target analytes. Because there were multiple interactions between adsorbent and analytes, the MMF-SPME exhibited a high extractive capability toward analytes. To obtain optimum extraction performance, several extraction parameters including desorption solvent, pH value and ionic strength in sample matrix, extraction and desorption time were investigated and discussed. Under the optimized extraction conditions, the limits of detection (S/N=3) of the proposed method were 0.
2.Determination of 13 endocrine disrupting chemicals in sediments by gas chromatography-mass spectrometry using subcritical water extraction coupled with dispersed liquid-liquid microextraction and derivatization.
Yuan K1, Kang H2, Yue Z2, Yang L3, Lin L1, Wang X4, Luan T1. Anal Chim Acta. 2015 Mar 25;866:41-7. doi: 10.1016/j.aca.2015.02.011. Epub 2015 Feb 10.
In this study, a sample pretreatment method was developed for the determination of 13 endocrine disrupting chemicals (EDCs) in sediment samples based on the combination of subcritical water extraction (SWE) and dispersed liquid-liquid microextraction (DLLME). The subcritical water that provided by accelerated solvent extractor (ASE) was the sample solution (water) for the following DLLME and the soluble organic modifier that spiked in the subcritical water was also used as the disperser solvent for DLLME in succession. Thus, several important parameters that affected both SWE and DLLME were investigated, such as the extraction solvent for DLLME (chlorobenzene), extraction time for DLLME (30s), selection of organic modifier for SWE (acetone), volume of organic modifier (10%) and extraction temperature for SWE (150 °C). In addition, good chromatographic behavior was achieved for GC-MS after derivatisation by using N,O-bis(trimethylsilyl) trifluoroacetamide (BSTFA).
3.Evaluation of two molecularly imprinted polymers for the solid-phase extraction of natural, synthetic and mycoestrogens from environmental water samples before liquid chromatography with mass spectrometry.
González-Sálamo J1, Socas-Rodríguez B1, Hernández-Borges J1, Del Mar Afonso M2, Rodríguez-Delgado MÁ1. J Sep Sci. 2015 Aug;38(15):2692-9. doi: 10.1002/jssc.201500194. Epub 2015 Jun 30.
In this work, we have compared the selectivity of two commercial molecularly imprinted polymers (AFFINIMIP®SPE Estrogens and AFFINIMIP®SPE Zearalenone) for the extraction of 12 estrogenic compounds of interest (i.e. 17α-estradiol, 17β-estradiol, estrone, hexestrol, 17α-ethynylestradiol, diethylstibestrol, dienestrol, zearalenone, α-zearalanol, β-zearalanol, α-zearalenol and β-zearalenol) from different water samples. High-performance liquid chromatography coupled with ion trap mass spectrometry with electrospray ionization was used for their determination. Results showed that although both molecularly imprinted polymeric cartridges were specifically designed for different groups of analytes (natural estrogens like estradiol in the first case and zearalenone derivatives in the second) they nearly have the same extraction performance (with recovery values in the range 65-101%) for the same analytes in Milli-Q water because of the cross-reactivity of the polymer.
4.Sequence to structure approach of estrogen receptor alpha and ligand interactions.
Chamkasem A1, Toniti W. Asian Pac J Cancer Prev. 2015;16(6):2161-6.
Estrogen receptors (ERs) are steroid receptors located in the cytoplasm and on the nuclear membrane. The sequence similarities of human ERα, mouse ERα, rat ERα, dog ERα, and cat ERα are above 90%, but structures of ERα may different among species. Estrogen can be agonist and antagonist depending on its target organs. This hormone play roles in several diseases including breast cancer. There are variety of the relative binding affinity (RBA) of ER and estrogen species in comparison to 17β-estradiol (E2), which is a natural ligand of both ERα and ERβ. The RBA of the estrogen species are as following: diethyl stilbestrol (DES)>hexestrol>dienestrol>17β-estradiol (E2)>17-estradiol>moxestrol>estriol (E3)>4-OH estradiol>estrone-3-sulfate. Estrogen mimetic drugs, selective estrogen receptor modulators (SERMs), have been used as hormonal therapy for ER positive breast cancer and postmenopausal osteoporosis. In the postgenomic era, in silico models have become effective tools for modern drug discovery.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products


CAS 94-24-6 Tetracaine

Tetracaine
(CAS: 94-24-6)

Tetracaine is a topical local anesthetic for the eyes. It works by interfering with entry of sodium ions into nerve cells. It is also used in assessing the pote...

CAS 118525-35-2 Sagittatoside A

Sagittatoside A
(CAS: 118525-35-2)

Sagittatoside A is a natural compound isolated from traditional Chinese herb Yinyanghuo.

Pexacerfont
(CAS: 459856-18-9)

Corticotropin-releasing factor (CRF), also known as corticotropin-releasing hormone, is an endogenous peptide hormone which is released in response to various t...

CAS 50-56-6 Oxytocin

Oxytocin
(CAS: 50-56-6)

Oxytocin is a mammalian neurohypophysial hormone. It plays an important role in the neuroanatomy of intimacy, specifically in sexual reproduction of both sexes,...

CAS 370893-06-4 Ancriviroc

Ancriviroc
(CAS: 370893-06-4)

Ancriviroc, an oximino-piperidino-piperidine-amide, is a CCR5 receptor antagonist.

GSK-7975A
(CAS: 1253186-56-9)

This active molecular is a calcium release-activated calcium modulator (ORAI1) inhibitor. GSK-7975A inhibited toxin-induced activation of ORAI1 and/or activatio...

CAS 300586-90-7 OAC1

OAC1
(CAS: 300586-90-7)

OAC1 is a Octamer-binding transcription factor 4 (Oct4)-activating compound; enhances the iPSC reprogramming efficiency and accelerated the reprogramming proces...

Remeglurant
(CAS: 1309783-00-3)

Remeglurant is a selective Metabotropic glutamate receptor 5 antagonist originated by Merz Pharmaceuticals. Phase-I for Drug-induced dyskinesia in USA was on-go...

LY-201409
(CAS: 109306-94-7)

LY-201409 is a potent benzamide anticonvulsant. It antagonized maximal electroshock (MES)-induced seizures with ED50 values of 16.2 and 4.2 mg/kg after oral adm...

LY 140091
(CAS: 74814-56-5)

LY 140091 is a bio-active chemical, but no detailed information has been published yet.

JNJ-10329670
(CAS: 400797-24-2)

JNJ-10329670 represents a novel class of immunosuppressive compounds with a highly potent (Ki ~30 nM)

CAS 144494-65-5 Tirofiban HCl

Tirofiban HCl
(CAS: 144494-65-5)

Tirofiban (MK-383, Aggrastat) is a nonpeptide derivative of tyrosine that selectively inhibits the GP-IIb/IIIa receptor, with minimal effects on the ɑvβ3 vitron...

CAS 1035979-44-2 P005672 HCl

P005672 HCl
(CAS: 1035979-44-2)

P005672 HCl is a novel, tetracycline-substituted, narrow-spectrum antibiotic compound used for treatment of bacterial infections and neoplasms. It is developed ...

CAS 57248-88-1 Pamidronate Disodium

Pamidronate Disodium
(CAS: 57248-88-1)

Pamidronic acid (INN) or pamidronate disodium (USAN), pamidronate disodium pentahydrate is a nitrogen-containingbisphosphonate, used to prevent osteoporosis.

LY 189332
(CAS: 123215-05-4)

LY 189332 is a bio-active molecular under the development of Eli Lilly as an antimetastatic drug.

CAS 148893-10-1 HATU

HATU
(CAS: 148893-10-1)

HATU, a triazolopyridine dirivative, has been found to be a peptide coupling reagent and could be used in the formation of of Aurora A kinase inhibitors.

CAS 75450-34-9 CGP 37157

CGP 37157
(CAS: 75450-34-9)

CGP 37157 is a a selective sodium-calcium exchanger inhibitor with IC50 value of 0.36 μM in isolated mitochondria. It does not affect channels, exchangers, or A...

CAS 548-62-9 Crystal Violet

Crystal Violet
(CAS: 548-62-9)

Crystal violet is a triarylmethane dye.

CAS 2016795-77-8 EC330

EC330
(CAS: 2016795-77-8)

EC330 is a novel steroidal LIF inhibitor showed cytotoxicity in various cancer cell lines and NCI-60 cell line panel at low nano-molar range, blocked formation ...

CAS 121104-96-9 Celgosivir

Celgosivir
(CAS: 121104-96-9)

Celgosivir, an effective α-glucosidase I inhibitor, has been found to be related to viral maturation and is still under Phase I/II trial against Dengue. IC50: 1...

Chemical Structure

CAS 84-17-3 Dienestrol

Quick Inquiry

Verification code

Featured Items