Dicycloverine (Dicyclomine) - CAS 77-19-0
Catalog number: 77-19-0
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C19H35NO2
Molecular Weight:
309.49
COA:
Inquire
Targets:
mAChR
Description:
Dicycloverine, also known as dicyclomine, is an anticholinergic that blocks muscarinic receptors.
Purity:
>95%
Solubility:
Soluble in DMSO
Storage:
-20℃ Freezer
MSDS:
Inquire
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
InChIKey:
CURUTKGFNZGFSE-UHFFFAOYSA-N
InChI:
InChI=1S/C19H35NO2/c1-3-20(4-2)15-16-22-18(21)19(13-9-6-10-14-19)17-11-7-5-8-12-17/h17H,3-16H2,1-2H3
Canonical SMILES:
CCN(CC)CCOC(=O)C1(CCCCC1)C2CCCCC2
1.Maternal safety of the delayed-release doxylamine and pyridoxine combination for nausea and vomiting of pregnancy; a randomized placebo controlled trial.
Koren G1,2,3, Clark S4,5, Hankins GD6,7, Caritis SN8,9, Umans JG10,11, Miodovnik M12,13, Mattison DR14, Matok I15,16. BMC Pregnancy Childbirth. 2015 Mar 18;15:59. doi: 10.1186/s12884-015-0488-1.
BACKGROUND: Nausea and vomiting of pregnancy (NVP) is the most common medical condition in pregnancy, affecting up to 80% of expecting mothers. In April 2013 the FDA approved the delayed release combination of doxylamine succinate and -pyridoxine hydrochloride (Diclegis®) for NVP, following a phase 3 randomized trial in pregnant women. The fetal safety of this medication has been proven by numerous studies. However, because it is the only FDA-approved medication for NVP that is likely to be used by a large number of pregnant women, its maternal safety is an important public health question. The Objective is to evaluate the maternal safety of doxylamine succinate -pyridoxine hydrochloride delayed-release preparation (Diclegis® as compared to placebo.
2.Potentially inappropriate anticholinergic medication use in community-dwelling older adults: a national cross-sectional study.
Kachru N1, Carnahan RM, Johnson ML, Aparasu RR. Drugs Aging. 2015 May;32(5):379-89. doi: 10.1007/s40266-015-0257-x.
BACKGROUND: Inappropriate medications are often used in older adults despite their unfavourable risk-to-benefit profile. Although many of the medications in the American Geriatrics Society (AGS) Beers list are potentially inappropriate because of their anticholinergic properties, little is known regarding the nature and extent of potentially inappropriate anticholinergic medication use in older adults.
3.Pharmacological justification of use of Solena heterophylla Lour. in gastrointestinal, respiratory and vascular disorders.
Janbaz KH1, Akhtar T2, Saqib F3, Imran I4, Zia-Ul-Haq M5,6, Jansakul C7, De Feo V8, Moga M9. J Transl Med. 2015 Apr 30;13:134. doi: 10.1186/s12967-015-0470-8.
BACKGROUND: Solena heterophylla Lour. has traditionally been used in the management of diseases pertaining to gastrointestinal, respiratory and vascular system and present study was undertaken to validate its traditional uses.
4.Scientific basis for use of Pyrus pashia Buch.-Ham. ex D. Don. fruit in gastrointestinal, respiratory and cardiovascular ailments.
Janbaz KH1, Zaeem Ahsan M1, Saqib F1, Imran I1, Zia-Ul-Haq M2, Abid Rashid M3, Jaafar HZ4, Moga M5. PLoS One. 2015 Mar 18;10(3):e0118605. doi: 10.1371/journal.pone.0118605. eCollection 2015.
BACKGROUND: Pyrus pashia Buch.-Ham. ex D. Don. has been used conventionally by many communities in the Himalayan region for the management of gastrointestinal, respiratory, and vascular complications. Set against this background, this study was carried out to justify the scientific basis to validate folkloric uses of fruits of Pyrus pashia Buch.-Ham. ex D. Don. (Pp.Cr) in traditional systems of medicine.
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CAS 77-19-0 Dicycloverine (Dicyclomine)

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