Dictamine - CAS 484-29-7
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Not Intended for Therapeutic Use. For research use only.
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Dictamnine has the ability to exert cytotoxicity in human cervix, colon, and oral carcinoma cells; It has been reported to have antimicrobial activity against bacteria and fungi.
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Dictamnine; Dectamine
1.[Chemical constituents from root bark of Dictamnus dasycarpus].
Bai YY, Tang WZ, Wang XJ. Zhong Yao Cai. 2014 Feb;37(2):263-5.
OBJECTIVE: To isolate and identify the chemical constituents from the root bark of Dictamnus dasycarpus.
2.Metabolism of dictamnine in liver microsomes from mouse, rat, dog, monkey, and human.
Wang P1, Zhao Y2, Zhu Y3, Sun J4, Yerke A3, Sang S3, Yu Z5. J Pharm Biomed Anal. 2016 Feb 5;119:166-74. doi: 10.1016/j.jpba.2015.11.016. Epub 2015 Nov 18.
Dictamnine, a furoquinoline alkaloid isolated from the root bark of Dictamnus dasycarpus Turcz. (Rutaceae), is reported to have a wide range of pharmacological activities. In this study, the in vitro metabolic profiles of dictamnine in mouse, rat, dog, monkey, and human liver microsomes were investigated and compared. Dictamnine was incubated with liver microsomes in the presence of an NADPH-regenerating system, resulting in the formation of eight metabolites (M1-M8). M1 is an O-desmethyl metabolite. M5 and M6 are formed by a mono-hydroxylation of the benzene ring of dictamnine. M8 was tentatively identified as an N-oxide metabolite. The predominant metabolic pathway of dictamnine occurs through the epoxidation of the 2,3-olefinic to yield a 2,3-epoxide metabolite (M7), followed by the ring of the epoxide opening to give M4. Likewise, cleavage of the furan ring forms M2 and M3. Slight differences were observed in the in vitro metabolic profiles of dictamnine among the five species tested.
3.Dihydroartemisinine enhances dictamnine-induced apoptosis via a caspase dependent pathway in human lung adenocarcinoma A549 cells.
An FF1, Liu YC, Zhang WW, Liang L. Asian Pac J Cancer Prev. 2013;14(10):5895-900.
Dictamnine (Dic) has the ability to exert cytotoxicity in human cervix, colon, and oral carcinoma cells and dihydroartemisinin (DHA) also has potent anticancer activity on various tumour cell lines. This report explores the molecular mechanisms by which Dic treatment and combination treatment with DHA and Dic cause apoptosis in human lung adenocarcinoma A549 cells. Dic treatment induced concentration- and time-dependent cell death. FCM analysis showed that Dic induced S phase cell cycle arrest at low concentration and cell apoptosis at high concentration in which loss of mitochondrial membrane potential (Δψmm) was not involved. In addition, inhibition of caspase-3 using the specific inhibitor, z-DQMD-fmk, did not attenuate Dic-induced apoptosis, implying that Dic-induced caspase-3-independent apoptosis. Combination treatment with DHA and Dic dramatically increased the apoptotic cell death compared to Dic alone. Interestingly, pretreatment with z-DQMD-fmk significantly attenuated DHA and Dic co-induced apoptosis, implying that caspase-3 plays an important role in Dic and DHA co-induced cell apoptosis.
4.Developing an activity and absorption-based quality control platform for Chinese traditional medicine: Application to Zeng-Sheng-Ping(Antitumor B).
Yin T1, Yang G2, Ma Y1, Xu B1, Hu M3, You M4, Gao S5. J Ethnopharmacol. 2015 Aug 22;172:195-201. doi: 10.1016/j.jep.2015.06.019. Epub 2015 Jun 20.
ETHNOPHARMACOLOGICAL RELEVANCE: Zeng-Sheng-Ping (ZSP), also called antitumor B, is a marketed Chinese traditional medicine used for cancer prevention.
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CAS 484-29-7 Dictamine

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