Dicloxacillin sodium monohydrate - CAS 13412-64-1
Catalog number:
13412-64-1
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C19H16Cl2N3NaO5S.H2O
Molecular Weight:
510.30
COA:
Inquire
Targets:
Antibacterial
Description:
The sodium monohydrate salt form of Dicloxacillin, a β-Lactam compound, could be used as an antibiotic especially against Gram-positive bacteria and also be significant in biological studies.
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Purity:
95%
Appearance:
White to off-white crystalline powder
Synonyms:
3-(2,6-DICHLOROPHENYL)-5-METHYL-4-ISOXAZOLYL PENICILLIN;DICLOXACILLIN SODIUM SALT HYDRATE VETRAN;DICLOXACILLIN SODIUM EPD(CRM STANDARD);DICLOXACILLIN SODIUM USP(CRM STANDARD);DICLOXACILLIN SODIUM WHO(CRM STANDARD);4-Thia-1-azabicyclo3.2.0heptane-2-carbox
Solubility:
H2O: > 40 mg/mL
Storage:
2-8ºC
MSDS:
Inquire
Application:
The sodium monohydrate salt form of Dicloxacillin could be used as an antibiotic especially against Gram-positive bacteria and also be significant in biological studies.
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Grams-Kilos
Boiling Point:
692.4ºC at 760mmHg
Melting Point:
222-225ºC
InChIKey:
GXOMMGAFBINOJY-SLINCCQESA-N
InChI:
InChI=1S/C19H17Cl2N3O5S.Na/c1-7-10(12(23-29-7)11-8(20)5-4-6-9(11)21)15(25)22-13-16(26)24-14(18(27)28)19(2,3)30-17(13)24;/h4-6,13-14,17H,1-3H3,(H,22,25)(H,27,28);/q;+1/t13-,14+,17-;/m1./s1
Canonical SMILES:
CC1=C(C(=NO1)C2=C(C=CC=C2Cl)Cl)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)O.[Na+]
1.Selective spectrophotometric determination of phenolic beta-lactam antibiotics.
Salem H1, Saleh GA. J Pharm Biomed Anal. 2002 Jun 15;28(6):1205-13.
Two simple and selective spectrophotometric methods were developed for the quantitative determination of cefoperazone sodium, cefadroxil monohydrate, cefprozil anhydrous and amoxicillin trihydrate in pure forms as well as in their pharmaceutical formulations. The methods are based on the selective oxidation of these drugs with either Ce (IV) or Fe (III) in acid medium to give an intense yellow coloured product (lambda(max)=397 nm). The reaction conditions were studied and optimized. Beer's plots were obeyed in a general concentration range of 5-30 microg ml(-1) with correlation coefficients not less than 0.9979 for the four drugs with the two reagents. The methods are successfully applied to the analysis of pharmaceutical formulations containing amoxicillin, either alone or in combination with potassium clavulanate, flucloxacillin or dicloxacillin. They were also applied to the analysis of the other three studied drugs in vials, capsules, tablets and suspensions with good recovery; percent ranged from 99.
2.Bacteriology of acute otitis media in Japanese children.
Fujita K, Iseki K, Yoshioka H, Sasaki T, Ando T, Nakamura M. Am J Dis Child. 1983 Feb;137(2):152-4.
Bacteriologic investigations were performed on 100 children with acute otitis media by culturing the fluid from a myringotomy site. Patients ranged in age from 7 months to 14 years, and 91 were younger than 6 years old. Bacterial isolates were yielded from cultures in 83 cases, and mixtures of two or three organisms were obtained from 15 patients. Among the total of 100 isolates, the most predominant organism was Streptococcus pneumoniae (28), followed by Hemophilus influenzae (26), Staphylococcus aureus (19), and Streptococcus pyogenes (six). Minimal inhibitory concentrations (MICs) of ampicillin sodium against S pneumoniae and H influenzae were 0.016 to 0.032 and 0.25 to 0.5 mg/L, respectively. None of the strains of H influenzae were resistant to ampicillin. The MICs of dicloxacillin sodium, cephalexin monohydrate, cefaclor, and erythromycin to H influenzae were 8 to 32, 8 to 16, 2 to 8, and 2 to 8 mg/L, respectively. The preferred drug for acute otitis media would be ampicillin in Japan, but we have to consider antistaphylococcal antibiotics for the patients who do not respond to 48 hours of treatment.
3.Sodium dicloxacillin monohydrate: an anti-staphylococcus antibiotic.
Keefe TJ, Christie GJ. Acta Chir Plast. 1973;15(1):904 passim.
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CAS 13412-64-1 Dicloxacillin sodium monohydrate

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