Diclofenac - CAS 15307-86-5
Catalog number: 15307-86-5
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C14H11Cl2NO2
Molecular Weight:
296.15
COA:
Inquire
Targets:
Cox-2 | COX
Description:
A non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively.
Brife Description:
A non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively.
Appearance:
Off-White to Pale Beige Solid
Synonyms:
Voltaren; Ecofenac; Solaraze
Solubility:
DMSO: > 3.5 mg/mL
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
MSDS:
Inquire
Quality Standard:
In-house
Quantity:
Grams-Kilos
Melting Point:
157-158°C
InChIKey:
DCOPUUMXTXDBNB-UHFFFAOYSA-N
InChI:
1S/C14H11Cl2NO2/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19/h1-7,17H,8H2,(H,18,19)
Canonical SMILES:
C1=CC=C(C(=C1)CC(=O)O)NC2=C(C=CC=C2Cl)Cl
1.Addition of fentanyl to the ultrasound-guided transversus abdominis plane block does not improve analgesia following cesarean delivery.
Wang LZ1, Liu X2, Zhang YF1, Hu XX1, Zhang XM1. Exp Ther Med. 2016 Apr;11(4):1441-1446. Epub 2016 Feb 8.
The present study aimed to investigate whether the addition of fentanyl to the transversus abdominis plane (TAP) block procedure may improve analgesic duration following cesarean delivery. A total of 147 nulliparous women with an American Society of Anesthesiologists physical status I-II, scheduled for elective cesarean delivery under spinal anesthesia, were enrolled in the present study. All patients underwent cesarean delivery under spinal anesthesia with 10 mg bupivacaine and 10 µg fentanyl, after which the patients underwent an ultrasound-guided bilateral TAP block with either 0.375% ropivacaine (group TR; n=48), 0.375% ropivacaine and 50 µg subcutaneous fentanyl (group TRSF; n=49), or a mixture of 0.375% ropivacaine and 50 µg fentanyl (2.5 µg/ml; group TRF; n=50) per side. The TAP block formed part of a multimodal analgesic regimen comprising patient-controlled analgesia (PCA) with intravenous fentanyl, and regular treatment with diclofenac and paracetamol.
2.Effects of intra-articular SHINBARO treatment on monosodium iodoacetate-induced osteoarthritis in rats.
Kim WK1, Chung HJ2, Pyee Y1, Choi TJ1, Park HJ1, Hong JY1, Shin JS3, Lee JH3, Ha IH3, Lee SK1. Chin Med. 2016 Apr 11;11:17. doi: 10.1186/s13020-016-0089-6. eCollection 2016.
BACKGROUND: SHINBARO is a refined herbal formulation used to treat inflamed lesions and bone diseases. This study aimed to investigate the anti-osteoarthritic activities of intra-articular administration of SHINBARO and determine its underlying molecular mechanism in a monosodium iodoacetate (MIA)-induced osteoarthritis rat model.
3.Impact of treated wastewater reuse and floods on water quality and fish health within a water reservoir in an arid climate.
Zaibel I1, Zilberg D2, Groisman L3, Arnon S4. Sci Total Environ. 2016 Apr 8;559:268-281. doi: 10.1016/j.scitotenv.2016.03.099. [Epub ahead of print]
Treated wastewater (TWW) reuse for agricultural irrigation is a well-established approach to coping with water shortages in semi-arid and arid environments. Recently, additional uses of TWW have emerged, including streamflow augmentation and aquatic ecosystem restoration. The purpose of the current study was to evaluate the water quality and fish health, in an artificial reservoir located in an arid climate (the Yeruham Reservoir, Israel), which regularly receives TWW and sporadic winter floods. The temporal distribution of water levels, nutrients and organic micropollutants (OMPs) were measured during the years 2013-2014. OMPs were also measured in sediment and fish tissues. Finally, the status of fish health was evaluated by histopathology. Water levels and quality were mainly influenced by seasonal processes such as floods and evaporation, and not by the discharge of TWW. Out of 16 tested OMPs, estrone, carbamazepine, diclofenac and bezafibrate were found in the reservoir water, but mostly at concentrations below the predicted no-effect concentration (PNEC) for fish.
4.The effect of topical diclofenac 3% and calcitriol 3 μg/g on superficial basal cell carcinoma (sBCC) and nodular basal cell carcinoma (nBCC): A phase II, randomized controlled trial.
Brinkhuizen T1, Frencken KJ2, Nelemans PJ3, Hoff ML4, Kelleners-Smeets NW2, Hausen AZ5, van der Horst MP5, Rennspiess D5, Winnepenninckx VJ5, van Steensel MA6, Mosterd K2. J Am Acad Dermatol. 2016 Apr 7. pii: S0190-9622(16)00130-4. doi: 10.1016/j.jaad.2016.01.050. [Epub ahead of print]
BACKGROUND: Nonsteroidal anti-inflammatory drugs and vitamin-D derivatives can target signaling pathways activated in basal cell carcinoma (BCC).
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Chemical Structure

CAS 15307-86-5 Diclofenac

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