Dexrazoxane hydrochloride - CAS 149003-01-0
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Not Intended for Therapeutic Use. For research use only.
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Dexrazoxane hydrochloride is an intracellular iron chelator, which decreases the formation of superoxide radicals, used as a cardioprotective agent.
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ICRF-187 (ADR-529) HCl
1.Carfilzomib-induced cardiotoxicity mitigated by dexrazoxane through inhibition of hypertrophic gene expression and oxidative stress in rats.
Al-Harbi NO1. Toxicol Mech Methods. 2016 Mar;26(3):189-95. doi: 10.3109/15376516.2016.1143071. Epub 2016 Feb 21.
Carfilzomib (CFZ) is an inhibitor of proteasome that is generally used in the treatment of multiple myeloma but due to its cardiotoxicity clinical use may be limited. Dexrazoxane (DZR), an inhibitor of topoisomerase-II, prevents cardiac damage by reducing the formation of reactive oxygen species and hypertrophic gene expression. This study evaluated the protective effect of DZR on CFZ-induced cardiotoxicity. Thirty-two male Albino rats were randomly divided into four groups (n = 8). Group I received DMSO, Group II received CFZ (4 mg/kg, intraperitoneally [i.p.]) twice weekly up to day 16, Group III received DZR (20 mg/kg, i.p.) for 16 days and CFZ twice weekly for 16, Group IV received DZR (40 mg/kg, i.p.) for 16 days and CFZ twice weekly for 16. CFZ-induced cardiotoxicity was assessed by hematological, biochemical, mRNA expression, oxidative stress and histopathological studies. CFZ-induced significant changes have been observed in blood parameters including red blood cells, white blood cells, hemoglobin and hematocrit concentrations which were associated with increase in cardiac enzymes markers like creatine kinase (CK), CK-MB and lactate dehydrogenase.
2.Overview, prevention and management of chemotherapy extravasation.
Kreidieh FY1, Moukadem HA1, El Saghir NS1. World J Clin Oncol. 2016 Feb 10;7(1):87-97. doi: 10.5306/wjco.v7.i1.87.
Chemotherapy extravasation remains an accidental complication of chemotherapy administration and may result in serious damage to patients. We review in this article the clinical aspects of chemotherapy extravasation and latest advances in definitions, classification, prevention, management and guidelines. We review the grading of extravasation and tissue damage according to various chemotherapeutic drugs and present an update on treatment and new antidotes including dexrazoxane for anthracyclines extravasation. We highlight the importance of education and training of the oncology team for prevention and prompt pharmacological and non-pharmacological management and stress the availability of new antidotes like dexrazoxane wherever anthracyclines are being infused.
3.Oxidative stress does not play a primary role in the toxicity induced with clinical doses of doxorubicin in myocardial H9c2 cells.
Rharass T1,2, Gbankoto A3, Canal C1, Kurşunluoğlu G4, Bijoux A1, Panáková D2, Ribou AC5,6. Mol Cell Biochem. 2016 Feb;413(1-2):199-215. doi: 10.1007/s11010-016-2653-x. Epub 2016 Jan 30.
The implication of oxidative stress as primary mechanism inducing doxorubicin (DOX) cardiotoxicity is still questionable as many in vitro studies implied supra-clinical drug doses or unreliable methodologies for reactive oxygen species (ROS) detection. The aim of this study was to clarify whether oxidative stress is involved in compliance with the conditions of clinical use of DOX, and using reliable tools for ROS detection. We examined the cytotoxic mechanisms of 2 μM DOX 1 day after the beginning of the treatment in differentiated H9c2 rat embryonic cardiac cells. Cells were exposed for 2 or 24 h with DOX to mimic a single chronic dosage or to favor accumulation, respectively. We found that apoptosis was prevalent in cells exposed for a short period with DOX: cells showed typical hallmarks as loss of anchorage ability, mitochondrial hyperpolarization followed by the collapse of mitochondrial activity, and nuclear condensation. Increasing the exposure period favored a shift to necrosis as the cells preferentially exhibited early DNA impairment and nuclear swelling.
4.ReCAP: Detection of Potentially Avoidable Harm in Oncology From Patient Medical Records.
Lipitz-Snyderman A1, Weingart SN2, Anderson C2, Epstein AS2, Killen A2, Classen D2, Sima CS2, Fortier E2, Atoria CL2, Pfister D2, Lipitz-Snyderman A3, Weingart SN2, Anderson C2, Epstein AS2, Killen A2, Classen D2, Sima CS2, Fortier E2, Atoria CL2, Pfister J Oncol Pract. 2016 Feb;12(2):178-9. doi: 10.1200/JOP.2015.006874.
QUESTION ASKED: Although medical record-based measurement of adverse events (AEs) associated with cancer care is desirable, condition-specific triggers in oncology care are needed. We sought to develop a screening tool to facilitate efficient detection of AEs across settings of cancer care via medical record review. We hope to use this tool to understand the frequency, spectrum, and preventability of AEs with the goal of helping improve the quality and safety of cancer care.
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CAS 149003-01-0 Dexrazoxane hydrochloride

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