1.The Influence of Perioperative Dexmedetomidine on Patients Undergoing Cardiac Surgery: A Meta-Analysis.
Geng J1, Qian J1, Cheng H1,2, Ji F1, Liu H2. PLoS One. 2016 Apr 6;11(4):e0152829. doi: 10.1371/journal.pone.0152829. eCollection 2016.
BACKGROUND: The use of dexmedetomidine may have benefits on the clinical outcomes of cardiac surgery. We conducted a meta-analysis comparing the postoperative complications in patients undergoing cardiac surgery with dexmedetomidine versus other perioperative medications to determine the influence of perioperative dexmedetomidine on cardiac surgery patients.
2.Dexmedetomidine Inhibits Maturation and Function of Human Cord Blood-Derived Dendritic Cells by Interfering with Synthesis and Secretion of IL-12 and IL-23.
Chen G1, Le Y1, Zhou L1, Gong L1, Li X1, Li Y1, Liao Q1, Duan K1, Tong J1,2, Ouyang W1. PLoS One. 2016 Apr 7;11(4):e0153288. doi: 10.1371/journal.pone.0153288. eCollection 2016.
AIMS: To investigate the effects and underlying mechanism of dexmedetomidine on the cultured human dendritic cells (DCs).
3.Dexmedetomidine versus Magnesium Sulfate as Adjunct during Anesthesia for Laparoscopic Colectomy.
Zarif P1, Abdelaal Ahmed Mahmoud A2, Abdelhaq MM1, Mikhail HM3, Farag A3. Anesthesiol Res Pract. 2016;2016:7172920. doi: 10.1155/2016/7172920. Epub 2016 Mar 9.
Objectives. To compare dexmedetomidine versus magnesium during laparoscopic colectomy. Patients and Methods. 51 patients were randomly allocated into 3 groups: group C (control) received saline infusion, group D dexmedetomidine 1 g/kg and then 0.4 g/kg/hr, and group M MgSO4 2 g and then 15 g/kg/min. Intraoperative hemodynamics were measured before and 1 min after intubation (T1 and T2), before and 5 min after peritoneal insufflation (T3 and T4), before and 5 min after 30° Trendelenburg position (T5 and T6), 5 min after resuming flat position (T7), 5 min after peritoneal deflations (T8), after extubation (T9), and at time of admission to PACU (T10). Recovery time and degree of sedation were assessed. Results. HR and MAP were significantly higher in T2, T4, and T6 compared to T1, T3, and T5, respectively, in all groups with lower measurements in groups D and M compared to group C. Mean of collective measurements was significantly higher in group C.
4.Dexmedetomidine attenuates inflammatory reaction in the lung tissues of septic mice by activating cholinergic anti-inflammatory pathway.
Liu Z1, Wang Y1, Wang Y2, Ning Q1, Zhang Y1, Gong C1, Zhao W1, Jing G1, Wang Q1. Int Immunopharmacol. 2016 Apr 10;35:210-216. doi: 10.1016/j.intimp.2016.04.003. [Epub ahead of print]
Dexmedetomidine (Dex) is a highly selective α2-adrenergic receptor agonist that is widely used for sedation in intensive care units and in clinical anesthesia. Dex has also been shown to possess anti-inflammatory benefits. However, the underlying mechanism by which Dex relieves the inflammatory reaction in the lung tissues of septic mice has not been fully elucidated. In this study, we aimed to evaluate the protective effects and possible mechanism of Dex on the sepsis-induced lung inflammatory response in mice. Sepsis was induced in mice models through the intraperitoneal injection of lipopolysaccharide (LPS). The preemptive administration of Dex substantially abated sepsis-induced pulmonary edema, pulmonary histopathological changes, and NF-κB p65 activity. The production of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) at both the mRNA and protein levels was also reduced. Moreover, these effects were significantly blocked by the α7 nicotinic acetylcholine receptor (α7nAChR) antagonist α-bungarotoxin (α-Bgt).