Dexchlorpheniramine maleate - CAS 2438-32-6
Catalog number: 2438-32-6
Category: Inhibitor
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Molecular Formula:
C20H23ClN2O4
Molecular Weight:
390.86
COA:
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Targets:
Histamine Receptor
Description:
Dexchlorpheniramine maleate, also known as Polaramine, is an antihistamine to treat allergic conditions, urticaria and allergic conjunctivitis and pruritus.
Appearance:
White Solid
Synonyms:
(Z)-but-2-enedioic acid;(3S)-3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine dexchlorpheniramine dexchlorpheniramine maleate dexchlorpheniramine maleate (1:1), (+-)-isomer dexchlorpheniramine maleate (1:1), (R)-isomer dexchlorpheniramine male
Solubility:
Soluble to 10 mM in H2O
Storage:
Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -111℃ for long term (months to years).
MSDS:
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Shelf Life:
2 years
Melting Point:
97-113°C
InChIKey:
DBAKFASWICGISY-DASCVMRKSA-N
InChI:
1S/C16H19ClN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t15-;/m0./s1
Canonical SMILES:
CN(C)CCC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2.C(=CC(=O)O)C(=O)O
1.A case of iatrogenic growth retardation induced by a corticosteroid-containing anti-allergic drug.
Nishikawa M;Hikosaka M;Yonemoto T;Gondou A;Tabata S;Ogawa Y;Kanasaki M;Miyake Y;Shimizu H;Shouzu A Horm Metab Res. 1995 Aug;27(8):376-8.
A nine-year old boy developed reduced growth velocity at the age of seven. The peak plasma growth hormone (GH) response to 3,4-dihydroxyphenylalanine, GH-releasing factor and insulin was 10.2, 8.1 and 7.6 micrograms/l, respectively, suggesting that the GH reserve was slightly reduced. Serum cortisol was undetectable and urinary excretion of 17-hydroxycorticosteroid was low (0.22-0.31 mg/day), but there were no physical or biochemical signs of adrenocortical insufficiency. He had taken an anti-allergic drug containing 0.25 mg of betamethasone and 2 mg of d-chlorpheniramine maleate per tablet for about 2 years to treat allergic rhinitis. Catch-up growth occurred when this drug was stopped. The present case suggests that daily administration of 0.25 mg of betamethasone can induce growth retardation and that ingestion of corticosteroid-containing preparations needs to be excluded in children who develop short stature without other symptoms.
2.Comparison of fortimicins with other aminoglycosides and effects on bacterial ribosome and protein synthesis.
Moreau N;Jaxel C;Le Goffic F Antimicrob Agents Chemother. 1984 Dec;26(6):857-62.
Fortimicins are bicyclic aminoglycoside antibiotics that contain a fortamine moiety instead of the deoxystreptamine found in other aminoglysides. Fortimicin A had a bactericidal effect on Escherichia coli and Staphylococcus epidermidis and was found to inhibit protein synthesis in vivo. In vitro, fortimicin A inhibited polyuridylic acid-directed phenylalanine polymerization and induced misreading, as shown by leucine incorporation. In contrast, fortimicin B had no effect on either polymerization or misreading. In assays programmed with natural mRNA, only a weak polymerization inhibition effect was observed with fortimicin A, whereas a strong stimulation was seen in the presence of fortimicin B. Both fortimicins A and B inhibited dissociation of 70S ribosomes into their subunits and neither was able to displace [3H]dihydrostreptomycin, [3H]tobramycin, or [3H]gentamicin from their respective binding sites on the 70S particle.
3.[Effect of gastrin and H2-receptor antagonist on electrical control activity following canine intestinal transection].
Murakuni H J Smooth Muscle Res. 1994 Jun;30(3):111-24.
Our objective was to study the mechanism of action of gastrin and histamin H2 receptor antagonist on the motility of the gastrointestinal area. In each of 12 mongrel dogs, eight bipolar electromyograms were obtained from the antrum of the stomach to the ileum on serosal surface, and in nine dogs undergoing that the small intestine was transected 20 cm from the ligament of Treitz. The effects of tetragastrin (1.0-10.0 microgram.kg-1.h-1) were studied against the presence of atropine, cimetidine and d-chlorpheniramine maleate. The frequency of electrical control activity (ECA) along the canine small intestine, and changes in ECAs frequency were studied normal and following upper small intestinal transection. In intact, the frequency of ECAs gradient decreased aborally in a stepwise fashion in normal intestine. Although the gradient was markedly reduced or even abolished distal to the level of transection, an intrinsic ECAs frequency gradient was demonstrated, it remained at a low level indefinitely. The normal ECA pattern and its alterations following transection were significantly influenced by tetragastrin. The act of tetragastrin in a dose of 1.0 to 5.0 microgram.kg-1.h-1 had not statistically effect on ECAs frequency and its dysrhythmias, and it did cause a small increase in the frequency of ECA at the antrum, whereas, with the highest dose (10.
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CAS 2438-32-6 Dexchlorpheniramine maleate

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