dexbrompheniramine - CAS 132-21-8
Catalog number: 132-21-8
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C16H19BrN2
Molecular Weight:
319.24
COA:
Inquire
Targets:
Histamine Receptor
Description:
Dexbrompheniramine is an histamine H1-receptor antagonist used for the treatment of allergic conditions including hay fever or urticaria. It is the pharmacologically active dextrorotatory isomer of brompheniramine. Dexbrompheniramine is a first generation antihistamine that reduces the effects of natural chemical histamine in the body including the symptoms like sneezing, itching, watery eyes, and runny nose.
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Purity:
95%
Appearance:
Powder
Synonyms:
DEXBROMPHENIRAMINE;DEXBROMPHENIRAMINE BASE;D-Brompheniramine;(S)-Brompheniramine;(S)-γ-(4-Bromophenyl)-N,N-dimethyl-2-pyridinepropan-1-amine;Disomer
Solubility:
Soluble in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
allergic conditions
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
Boiling Point:
403ºC at 760mmHg
Density:
1.265g/cm3
InChIKey:
ZDIGNSYAACHWNL-HNNXBMFYSA-N
InChI:
InChI=1S/C16H19BrN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3/t15-/m0/s1
Canonical SMILES:
CN(C)CCC(C1=CC=C(C=C1)Br)C2=CC=CC=N2
1.Simultaneous determination of pseudoephedrine sulfate, dexbrompheniramine maleate and loratadine in pharmaceutical preparations using derivative spectrophotometry and ratio spectra derivative spectrophotometry.
Onur F1, Yücesoy C, Dermiş S, Kartal M, Kökdil G. Talanta. 2000 Feb 7;51(2):269-79.
Two new spectrophotometric methods are described for the simultaneous analysis of pseudoephedrine sulfate-dexbrompheniramine maleate (DBP) and pseudoephedrine sulfate-loratadine combinations. In the first, derivative spectrophotometry, dA/dlambda values were read at zero-crossing points. In the second, ratio spectra derivative spectrophotometry, analytical signals were measured at the wavelengths corresponding to either maxima or minima for these drugs in the first derivative spectra of their ratio spectra. The procedures do not require any separation step. Mean recoveries were found to be >99% in the methods for these compounds in their synthetic mixtures. All the spectrophotometric methods proposed were compared with each other and HPLC which was also developed by us and applied to the pharmaceutical preparations selected.
2.Non-antibiotic treatments for upper-respiratory tract infections (common cold).
Arroll B1. Respir Med. 2005 Dec;99(12):1477-84.
OBJECTIVES: To review the seven Cochrane reviews of non-antibiotic treatment for the common cold.
3.Effects of histamine H1 receptors on the feeding and drinking patterns in pygmy goats.
Rossi R1, Del Prete E, Scharrer E. J Dairy Sci. 1998 Sep;81(9):2369-75.
The goal of these experiments was to determine which histamine receptors are involved in the relationship between drinking and feeding in ruminants. To this end, the effects of the histamine receptor antagonists dexbrompheniramine (H1 receptor antagonist), cimetidine (H2 receptor antagonist), and terfenadine (H1 receptor antagonist) on feeding and drinking patterns of pygmy goats were investigated. Two experiments using dexbrompheniramine [1 and 2 mg/kg of body weight (BW)0.75], two experiments using cimetidine (16 and 32 mg/kg of BW0.75), and two experiments using terfenadine (5 and 11.5 mg/kg of BW0.75) were performed to assess the type and location (periphery or central nervous system) of the histamine receptors involved in the mediation of prandial drinking by pygmy goats. The H1 receptor antagonists dexbrompheniramine (2 mg/kg of BW0.75) and terfenadine (11.5 mg/kg of BW0.75) significantly reduced water intake, but cumulative feed intake did not change.
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CAS 132-21-8 dexbrompheniramine

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