Detomidine HCl - CAS 90038-01-0
Catalog number:
B0084-079213
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C12H14N2·HCl
Molecular Weight:
222.71
COA:
Inquire
Targets:
Adrenergic Receptor
Description:
Detomidine is a selective α2-adrenoceptor agonist (Ki = 1.62 nM) that binds to α1-adrenoceptors with much weaker potency (Ki = 415 nM).
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-079213 500 mg $298 In stock
Bulk Inquiry
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
Related CAS:
90038-00-9 (Detomidine hydrochloride monohydrate)
MSDS:
Inquire
1.Laparoscopic cryptorchid castration in standing horses.
Hendrickson DA1, Wilson DG. Vet Surg. 1997 Jul-Aug;26(4):335-9.
OBJECTIVE: This article describes a new technique for laparoscopic cryptorchid castration in standing horses.
2.The influence of alpha-adrenergic receptors stimulator and blockers and beta-blocker on the ovary and endocrinological activity in heifers during superovulation.
Gajewski Z1, Thun R, Faundez R, Pawliński B. J Physiol Pharmacol. 2006 Nov;57 Suppl 8:173-88.
Twenty five Holstein-Friesian heifers, clinically normal and with regular oestrous cycles, were used for induction of superovulation (PMSG-PGF(2)alpha-Neutra-PMSG). Animals were divided into 5 groups receiving: I - detomidine (40 microg/kg b.w.), II - doxazosin (0.2 mg/kg b.w.), III - yohimbine HCL 1% (1 ml/50 kg b.w.), IV - carazolol (0.01 mg/ kg b.w., i.v.), and V - physiological saline (1 ml/50 kg b.w.). The heifers with PGF2 alpha-induced cycles were treated with the substances 88 hrs after being given a single i.m. injection of 2500 IU PMSG. All animals were examined by ultrasonography, and by the number and size of ovarian follicles > 3 mm in diameter. The follicles were divided into 3 groups according to the diameter. Blood plasma was stored at -20 degrees C until LH, P4, E2 and PGFM analyses. In the control (V) group, two waves of follicle growth were observed. Yohimbine produced a significant blockage of ovulation. The mean number of corpora lutea in the group III was significantly lower than that in the control group (p< 0.
3.Caudal analgesia induced by epidural or subarachnoid administration of detomidine hydrochloride solution in mares.
Skarda RT1, Muir WW 3rd. Am J Vet Res. 1994 May;55(5):670-80.
Seven adult mares were used to determine the analgesic, CNS, and cardiopulmonary effects of detomidine hydrochloride solution after epidural or subarachnoid administration, using both regimens in random sequence. At least 1 week elapsed between experiments. A 17-gauge Huber point (Tuohy) directional needle was used to place a catheter with stylet into either the epidural space at the first coccygeal interspace or the subarachnoid space at the lumbosacral intervertebral junction. Catheters were advanced so that the tips lay at the caudal sacral (S5 to S4) epidural space or at the midsacral (S3 to S2) subarachnoid space. Position of the catheter was confirmed radiographically. A 1% solution of detomidine HCl was injected into the epidural catheter at a dosage of 60 micrograms/kg of body weight, and was expanded to a 10-ml volume with sterile water to induce selective caudal epidural analgesia (CEA). A dose of 30 micrograms of detomidine HCl/kg expanded to a 3-ml volume with spinal fluid was injected into the subarachnoid catheter to induce caudal subarachnoid analgesia (CSA).
4.Adrenergic stimulation and blocking of hormonal secretion activity of cultured cow granulosa cells.
Gajewski Z1, Faundez R, Thun R, Pawliński B. J Physiol Pharmacol. 2006 Nov;57 Suppl 8:125-37.
The aim of this study was to determine the influence of alpha- and beta-stimulators (alpha-stimulator: detomidinum HCl) as well as blockers (alpha1-blocker: doxazosin, alpha2-blocker: yohimbinum HCL, beta-blocker: carazolol) on bovine granulosa cells culture from preovulatory follicles. The cell culture was passed in TCM 199 medium with 10% FCS and antibiotics. Tested substances were added to the culture medium in different concentrations. The experiment began when at least 80% of the wells were covered (in four well culture dish of NUNCK-DK). The culture medium was collected every 24 h for hormone analysis. Hormone levels of T, E2, and P4 were determined. The culture was used up to 120 hours. Our results showed a decrease in P-4 secretion after detomidinum addition for all tested concentrations. A slight testosterone level increase was seen in the first 24 hours and then its concentration remained at a constant low level. A slight increase in 17-beta estradiol secretion was also observed.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Adrenergic Receptor Products


CAS 65576-45-6 Asenapine

Asenapine
(CAS: 65576-45-6)

Asenapine is an atypical antipsychotic multireceptor neuroleptic drug by combining serotonin (5HT2) and dopamine (D2) receptor antagonist; structurally related ...

CAS 149247-12-1 QF0301B

QF0301B
(CAS: 149247-12-1)

QF0301B is an α1 adrenergic receptor antagonist and shows noncompetitive low action in 5-HT3, muscarinic and nicotinic receptors, or as Ca2+ antagonist.

CAS 128470-16-6 Arbutamine

Arbutamine
(CAS: 128470-16-6)

Arbutamine is β-adrenergic receptor originated by SICOR. It is a cardiac stimulant. Arbutamine is a synthetic catecholamine with positive chronotropic and inotr...

CAS 7361-61-7 Xylazine

Xylazine
(CAS: 7361-61-7)

Xylazine is an analogue of clonidine, which is an agonist at the α2 class of adrenergic receptor. It is a drug used for sedation, anesthesia, muscle relaxation ...

CAS 56-47-3 Deoxycorticosterone acetate

Deoxycorticosterone acetate
(CAS: 56-47-3)

Deoxycorticosterone acetate is a steroid hormone used for intramuscular injection for replacement therapy of the adrenocortical steroid.

CAS 133242-30-5 Landiolol

Landiolol
(CAS: 133242-30-5)

Landiolol is an ultra-short-acting Beta 1 adrenergic receptor antagonist using for managing supraventricular tachyarrhythmias in sepsis. It is also used as an a...

CAS 158599-53-2 Zoleprodolol

Zoleprodolol
(CAS: 158599-53-2)

Zoleprodolol, an oxadiazol derivative, has been found to be an adrenergic receptor antagonist.

CAS 57262-94-9 Setiptiline

Setiptiline
(CAS: 57262-94-9)

Setiptiline is is a serotonin receptor antagonist acts as a noradrenergic and specific serotonergic antidepressant.

Abanoquil mesilate
(CAS: 118931-00-3)

This molecular is an active biochemical as a Alpha 1 adrenergic receptor antagonist. However, no developments were reported for Ischaemic heart disorders and A...

CAS 51022-70-9 Salbutamol Sulfate

Salbutamol Sulfate
(CAS: 51022-70-9)

Salbutamol Sulfate is a Non-selective 2-adrenergic receptor agonist (IC50=8.93 µM)

CAS 106463-17-6 Tamsulosin HCl

Tamsulosin HCl
(CAS: 106463-17-6)

The hydrochloride salt form of Tamsulosin which could block on the sympathetic α1 receptor, especially selectively bind to the α1A receptor so that has been fou...

Nifenalol HCl

The hydrochloride of Nifenalol. Nifenalol is a beta-adrenoceptor antagonist used for the treatment of cardiovascular and cerebrovascular diseases such as hypert...

CAS 856620-39-8 O-desmethyl Mebeverine alcohol hydrochloride

O-desmethyl Mebeverine alcohol hydrochlo
(CAS: 856620-39-8)

O-desmethyl Mebeverine alcohol hydrochloride, a metabolite of Mebeverine, is a potent inhibitor of α1 repector, causing relaxation of the gastrointestinal tract...

CAS 81403-68-1 Alfuzosin HCl

Alfuzosin HCl
(CAS: 81403-68-1)

Alfuzosin HCl is an alpha1 receptor antagonist used to treat benign prostatic hyperplasia (BPH).

GYKI-16084
(CAS: 185739-21-3)

GYKI-16084 is a postsynaptic alpha2-blocker with the potential to treat benign prostatic hyperplasia.

CAS 43229-80-7 Formoterol Hemifumarate

Formoterol Hemifumarate
(CAS: 43229-80-7)

Formoterol Hemifumarate is a potent, selective and long-acting β2-adrenoceptor agonist to β2 and β1 receptors with pKd of 8.12 and 5.58, respectively.

Liafensine
(CAS: 1198790-53-2)

This active molecular is a SNDR (serotonin-norepinephrine-dopamine reuptake) inhibitor It was originated by Bristol-Myers Squibb for the treatment of major depr...

CAS 4205-91-8 Clonidine Hydrochloride

Clonidine Hydrochloride
(CAS: 4205-91-8)

Clonidine HCl is a direct-acting α2 adrenergic agonist with an ED50 of 0.02±0.01 mg/kg.

CAS 72795-01-8 ICI 118551 hydrochloride

ICI 118551 hydrochloride
(CAS: 72795-01-8)

ICI 118551 hydrochloride is a highly selective β2 adrenergic antagonist (Ki values are 1.2, 120 and 257 nM for β2, β1 and β3 receptors respectively), inhibited ...

CAS 86880-51-5 ICI141292

ICI141292
(CAS: 86880-51-5)

ICI141292, also known as Epanolol, is a adrenergic β-antagonist with a greater affinity for β1- than β2-adrenoceptors, which is used for treatment of hypertensi...

Chemical Structure

CAS 90038-01-0 Detomidine HCl

Quick Inquiry

Verification code

Featured Items