Detomidine - CAS 76631-46-4
Catalog number:
76631-46-4
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C12H14N2
Molecular Weight:
186.25
COA:
Inquire
Targets:
Adrenergic Receptor
Description:
Detomidine is an imidazole derivative and a α2-adrenergic agonist. It is usually used in the form of detomidine hydrochloride. It is used as a large animal sedative with analgesic properties, primarily used in horses. It also has cardiac and respiratory effects and an antidiuretic action due to inhibition of the sympathetic nervous system. It is a prescription medication available to veterinarians sold under the trade name Dormosedan, but it is only licenced for use in horses currently.
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Purity:
98%
Appearance:
Solid powder
Synonyms:
1H-Imidazole, 4-((2,3-dimethylphenyl)methyl)-;4-(2,3-Dimethylbenzyl)imidazol;Detomidina;4-(2,3-Dimethylbenzyl)-1H-imidazole
Solubility:
10 mM in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
Detomidine used as a large animal sedative with analgesic properties, primarily used in horses. It also has cardiac and respiratory effects and an antidiuretic action due to inhibition of the sympathetic nervous system.
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
Boiling Point:
386.5±11.0 °C | Condition: Press: 760 Torr
Melting Point:
114-116 °C
Density:
1.077±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
InChIKey:
RHDJRPPFURBGLQ-UHFFFAOYSA-N
InChI:
InChI=1S/C12H14N2/c1-9-4-3-5-11(10(9)2)6-12-7-13-8-14-12/h3-5,7-8H,6H2,1-2H3,(H,13,14)
Canonical SMILES:
CC1=C(C(=CC=C1)CC2=CN=CN2)C
1.[Feasibility and Safety of Dexmedetomidine Sedation in Transarterial Embolization for Hepatocellular Carcinoma with Hepatitis C-Related Cirrhosis].
Komemushi A1, Suzuki S, Sano A, Kariya S, Nakatani M, Yoshida RY, Kono Y, Ikeda K, Utsunomiya K, Harima Y, Tanigawa N. Gan To Kagaku Ryoho. 2015 Sep;42(9):1077-9.
BACKGROUND: Dexmedetomidine (Precedex®)is an agonist of a2-adrenergic receptors in certain parts of the brain. It was approved for "procedural sedation in the non-intubation in under local anesthesia" in June 2013 in Japan. However, because of metabolism delay, dexmedetomidine has to be administered carefully to patients with liver dysfunction.
2.Right atrial and right ventricular ultrasound-guided biopsy technique in standing horses.
Decloedt A1, de Clercq D1, Ven S1, van der Vekens N1, Chiers K2, van Loon G1. Equine Vet J. 2016 May;48(3):346-51. doi: 10.1111/evj.12433. Epub 2015 Apr 29.
REASONS FOR PERFORMING STUDY: Endomyocardial biopsies could be a valuable tool in equine cardiology for diagnosing myocardial disease, which is probably underdiagnosed in horses because of lack of specific diagnostic measures and limitations of currently available diagnostic methods.
3.Oxygen supplementation before induction of general anaesthesia in horses.
van Oostrom H1, Schaap MW2, van Loon JP3. Equine Vet J. 2015 Oct 29. doi: 10.1111/evj.12526. [Epub ahead of print]
REASONS FOR PERFORMING STUDY: Hypoventilation or apnoea, caused by the induction of general anaesthesia, may cause hypoxaemia. Pre-oxygenation may lengthen the period before this happens. No scientific studies are published on pre-oxygenation in equine anaesthesia.
4.Pharmacokinetics of detomidine following intravenous or oral-transmucosal administration and sedative effects of the oral-transmucosal treatment in dogs.
Messenger KM, Hopfensperger M, Knych HK, Papich MG. Am J Vet Res. 2016 Apr;77(4):413-20. doi: 10.2460/ajvr.77.4.413.
OBJECTIVE To determine the pharmacokinetics of detomidine hydrochloride administered IV (as an injectable formulation) or by the oral-transmucosal (OTM) route (as a gel) and assess sedative effects of the OTM treatment in healthy dogs. ANIMALS 12 healthy adult dogs. PROCEDURES In phase 1, detomidine was administered by IV (0.5 mg/m(2)) or OTM (1 mg/m(2)) routes to 6 dogs. After a 24-hour washout period, each dog received the alternate treatment. Blood samples were collected for quantification via liquid chromatography with mass spectrometry and pharmacokinetic analysis. In phase 2, 6 dogs received dexmedetomidine IV (0.125 mg/m(2)) or detomidine gel by OTM administration (0.5 mg/m(2)), and sedation was measured by a blinded observer using 2 standardized sedation scales while dogs underwent jugular catheter placement. After a l-week washout period, each dog received the alternate treatment. RESULTS Median maximum concentration, time to maximum concentration, and bioavailability for detomidine gel following OTM administration were 7.
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CAS 76631-46-4 Detomidine

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