Detomidine - CAS 76631-46-4
Catalog number:
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Adrenergic Receptor
Detomidine is an imidazole derivative and a α2-adrenergic agonist. It is usually used in the form of detomidine hydrochloride. It is used as a large animal sedative with analgesic properties, primarily used in horses. It also has cardiac and respiratory effects and an antidiuretic action due to inhibition of the sympathetic nervous system. It is a prescription medication available to veterinarians sold under the trade name Dormosedan, but it is only licenced for use in horses currently.
Publictions citing BOC Sciences Products
  • >> More
Solid powder
1H-Imidazole, 4-((2,3-dimethylphenyl)methyl)-;4-(2,3-Dimethylbenzyl)imidazol;Detomidina;4-(2,3-Dimethylbenzyl)-1H-imidazole
10 mM in DMSO
-20°C Freezer
Detomidine used as a large animal sedative with analgesic properties, primarily used in horses. It also has cardiac and respiratory effects and an antidiuretic action due to inhibition of the sympathetic nervous system.
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Boiling Point:
386.5±11.0 °C | Condition: Press: 760 Torr
Melting Point:
114-116 °C
1.077±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
Canonical SMILES:
1.[Feasibility and Safety of Dexmedetomidine Sedation in Transarterial Embolization for Hepatocellular Carcinoma with Hepatitis C-Related Cirrhosis].
Komemushi A1, Suzuki S, Sano A, Kariya S, Nakatani M, Yoshida RY, Kono Y, Ikeda K, Utsunomiya K, Harima Y, Tanigawa N. Gan To Kagaku Ryoho. 2015 Sep;42(9):1077-9.
BACKGROUND: Dexmedetomidine (Precedex®)is an agonist of a2-adrenergic receptors in certain parts of the brain. It was approved for "procedural sedation in the non-intubation in under local anesthesia" in June 2013 in Japan. However, because of metabolism delay, dexmedetomidine has to be administered carefully to patients with liver dysfunction.
2.Right atrial and right ventricular ultrasound-guided biopsy technique in standing horses.
Decloedt A1, de Clercq D1, Ven S1, van der Vekens N1, Chiers K2, van Loon G1. Equine Vet J. 2016 May;48(3):346-51. doi: 10.1111/evj.12433. Epub 2015 Apr 29.
REASONS FOR PERFORMING STUDY: Endomyocardial biopsies could be a valuable tool in equine cardiology for diagnosing myocardial disease, which is probably underdiagnosed in horses because of lack of specific diagnostic measures and limitations of currently available diagnostic methods.
3.Oxygen supplementation before induction of general anaesthesia in horses.
van Oostrom H1, Schaap MW2, van Loon JP3. Equine Vet J. 2015 Oct 29. doi: 10.1111/evj.12526. [Epub ahead of print]
REASONS FOR PERFORMING STUDY: Hypoventilation or apnoea, caused by the induction of general anaesthesia, may cause hypoxaemia. Pre-oxygenation may lengthen the period before this happens. No scientific studies are published on pre-oxygenation in equine anaesthesia.
4.Pharmacokinetics of detomidine following intravenous or oral-transmucosal administration and sedative effects of the oral-transmucosal treatment in dogs.
Messenger KM, Hopfensperger M, Knych HK, Papich MG. Am J Vet Res. 2016 Apr;77(4):413-20. doi: 10.2460/ajvr.77.4.413.
OBJECTIVE To determine the pharmacokinetics of detomidine hydrochloride administered IV (as an injectable formulation) or by the oral-transmucosal (OTM) route (as a gel) and assess sedative effects of the OTM treatment in healthy dogs. ANIMALS 12 healthy adult dogs. PROCEDURES In phase 1, detomidine was administered by IV (0.5 mg/m(2)) or OTM (1 mg/m(2)) routes to 6 dogs. After a 24-hour washout period, each dog received the alternate treatment. Blood samples were collected for quantification via liquid chromatography with mass spectrometry and pharmacokinetic analysis. In phase 2, 6 dogs received dexmedetomidine IV (0.125 mg/m(2)) or detomidine gel by OTM administration (0.5 mg/m(2)), and sedation was measured by a blinded observer using 2 standardized sedation scales while dogs underwent jugular catheter placement. After a l-week washout period, each dog received the alternate treatment. RESULTS Median maximum concentration, time to maximum concentration, and bioavailability for detomidine gel following OTM administration were 7.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Adrenergic Receptor Products

CAS 146-48-5 Yohimbine

(CAS: 146-48-5)

Yohimbine, an indolalkylamine alkaloid, blocks presynaptic alpha-2 adrenergic receptors. IC50= 0.6 μM Ki: 1.05 nM, alphaα2Areceptor

CAS 84638-81-3 ZK-90055 hydrochloride

ZK-90055 hydrochloride
(CAS: 84638-81-3)

ZK-90055, a β‐Adrenoceptor agonist, is a B-2 bronchodilator drug.

CAS 23239-51-2 Ritodrine Hydrochloride

Ritodrine Hydrochloride
(CAS: 23239-51-2)

Ritodrine HCl is a hydrochloride salt of ritodrine which is a β-2 adrenergic receptor agonist.Ritodrine (discontinued preparation: Yutopar) is a tocolytic drug,...

CAS 81161-17-3 Esmolol HCl

Esmolol HCl
(CAS: 81161-17-3)

Esmolol is a cardioselective beta1 receptor blocker with rapid onset, a very short duration of action, and no significant intrinsic sympathomimetic or membrane ...

CAS 19237-84-4 Prazosin Hydrochloride

Prazosin Hydrochloride
(CAS: 19237-84-4)

Prazosin HCl, a quinazoline derivative, is the first of a new chemical class of antihypertensives.

CAS 56392-17-7 Metoprolol Tartrate

Metoprolol Tartrate
(CAS: 56392-17-7)

Metoprolol Tartrate is a cardioselective β-adrenergic receptor blocker with IC50 of 42 ng/mL.

CAS 753498-25-8 Indacaterol Maleate

Indacaterol Maleate
(CAS: 753498-25-8)

Indacaterol is an ultra-long-acting β-adrenoceptor agonist with pKi of 7.36.

CAS 71576-40-4 Aptazapine

(CAS: 71576-40-4)

Aptazapine is a tetracyclic antidepressant. It was assayed in clinical trials for the treatment of depression in the 1980s but was never marketed. Aptazapine is...

CAS 503068-34-6 Vilanterol

(CAS: 503068-34-6)

Vilanterol (GW642444; GW 642444X) is a novel, inhaled, long-acting β(2) agonist with inherent 24-h activity under development as a once-daily combination therap...

CAS 72956-09-3 Carvedilol

(CAS: 72956-09-3)

Carvedilol is a non-selective beta blocker/alpha-1 blocker with an IC50 of 3.8 μM for inhibition of LDL oxidation.

CAS 81732-46-9 Bambuterol HCl

Bambuterol HCl
(CAS: 81732-46-9)

Bambuterol is a long acting beta-adrenoceptor agonist (LABA) used in the treatment of asthma.

CAS 119942-70-0 MK-912 hydrochloride

MK-912 hydrochloride
(CAS: 119942-70-0)

MK-912 is a potent new selective alpha 2-adrenergic receptor antagonist that is originated by Merck & Co for the treatment of Major depressive disorder. In Dec ...

CAS 65652-44-0 Pirbuterol acetate

Pirbuterol acetate
(CAS: 65652-44-0)

Pirbuterol acetate is a short-acting β2 adrenoreceptor agonist. It has bronchodilating action and is used as a bronchodilator. It is also used in the treatment ...

CAS 118457-16-2 (-)-Nebivolol

(CAS: 118457-16-2)

This active molecular is a β-adrenergic receptor antagonist. Levonebivolol is an enantiomer of Nebivolol which is a β1 receptor blocker with nitric oxide-potent...

(CAS: 508233-95-2)

Tedatioxetine is an antidepressant agent. It acts as a triple reuptake inhibitor and 5-HT2A, 5-HT2C, 5-HT3 and α1A-adrenergic receptor antagonist. It was discov...

CAS 7683-59-2 isoproterenol

(CAS: 7683-59-2)

Isoproterenol can be used for the treatment of bradycardia (slow heart rate), heart block, and rarely for asthma. It is a non-selective β adrenoreceptor agonist...

CAS 57149-07-2 Naftopidil

(CAS: 57149-07-2)

Naftopidil is a selective α1-adrenergic receptor antagonist or alpha blocker with a Ki of 58.3 nM.

CAS 51-42-3 Epinephrine Bitartrate

Epinephrine Bitartrate
(CAS: 51-42-3)

Epinephrine Bitartrate is an alpha- and beta-adrenergic receptor stimulator. It can be used for the treatment of asthma and cardiac failure via stimulating the ...

CAS 116209-55-3 Levobetaxolol HCl

Levobetaxolol HCl
(CAS: 116209-55-3)

Levobetaxolol exhibits a higher affinity at cloned human β1 and β2 receptors with Ki value of 0.76 nM and 32.6 nM, respectively.

CAS 86880-51-5 ICI141292

(CAS: 86880-51-5)

ICI141292, also known as Epanolol, is a adrenergic β-antagonist with a greater affinity for β1- than β2-adrenoceptors, which is used for treatment of hypertensi...

Chemical Structure

CAS 76631-46-4 Detomidine

Quick Inquiry

Verification code

Featured Items