Desogestrel - CAS 54024-22-5
Catalog number:
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Progesterone Receptor
Desogestrel is a progestogen with low androgenic potency used in hormonal contraceptives..
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Cerazette; (17α)-13-Ethyl-11-methylene-18,19-dinorpregn-4-en-20-yn-17-ol;
Soluble in DMSO
Store at -20 °C
A progestogen with low androgenic potency.
Quality Standard:
Enterprise Standard/USP/EP
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Boiling Point:
428.3ºC at 760 mmHg
Melting Point:
1.07 g/cm3
Canonical SMILES:
Current Developer:
1.Interventions for hirsutism excluding laser and photoepilation therapy alone: abridged Cochrane systematic review including GRADE assessments.
van Zuuren EJ1, Fedorowicz Z2. Br J Dermatol. 2016 Feb 19. doi: 10.1111/bjd.14486. [Epub ahead of print]
Hirsutism is a common disorder with a major impact on quality of life. The most frequent cause is polycystic ovary syndrome. Effects of interventions (except laser and light-based therapies) were evaluated, including GRADE assessments. Searches included Cochrane Skin Group Specialised Register, CENTRAL in The Cochrane Library, MEDLINE, EMBASE and five trials registers to June 2014. We included 157 randomised controlled trials (RCTs) with 10,550 participants. The majority were assessed 'high risk' of bias (123/157). The quality of evidence was rated moderate to very low for most outcomes. Pooled data for an oral contraceptive (OCP) (ethinyl estradiol (EE) and cyproterone acetate) compared with another OCP (EE and desogestrel) demonstrated both treatments were effective in reducing Ferriman-Gallwey scores, but the mean difference (MD) was not statistically significant (-1.84, 95% confidence interval (CI) -3.86 to 0.18). Flutamide was more effective than placebo in two studies (MD -7.
2.Committee Opinion No. 642: Increasing Access to Contraceptive Implants and Intrauterine Devices to Reduce Unintended Pregnancy.
Committee on Gynecologic Practice Long-Acting Reversible Contraception Working Group. Obstet Gynecol. 2015 Oct;126(4):e44-8. doi: 10.1097/AOG.0000000000001106.
Unintended pregnancy persists as a major public health problem in the United States. Although lowering unintended pregnancy rates requires multiple approaches, individual obstetrician-gynecologists may contribute by increasing access to contraceptive implants and intrauterine devices. Obstetrician-gynecologists should encourage consideration of implants and intrauterine devices for all appropriate candidates, including nulliparous women and adolescents. Obstetrician-gynecologists should adopt best practices for long-acting reversible contraception insertion. Obstetrician-gynecologists are encouraged to advocate for coverage and appropriate payment and reimbursement for every contraceptive method by all payers in all clinically appropriate circumstances.
3.A prospective, randomized, pharmacodynamic study of quick-starting a desogestrel progestin-only pill following ulipristal acetate for emergency contraception.
Brache V1, Cochon L2, Duijkers IJ3, Levy DP4, Kapp N4, Monteil C4, Abitbol JL4, Klipping C3. Hum Reprod. 2015 Dec;30(12):2785-93. doi: 10.1093/humrep/dev241. Epub 2015 Sep 23.
STUDY QUESTION: Is there a pharmacodynamic interaction between ulipristal acetate (UPA) 30 mg for emergency contraception and a daily progestin-only contraceptive pill, desogestrel (DSG) 0.75 mg, when initiated the next day?
4.[The "pill" for him remains a long-term pious aspiration].
Müller T. MMW Fortschr Med. 2015 Nov 12;157 Spec No 2:18.
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CAS 54024-22-5 Desogestrel

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