Desmethyl Bromethalin - CAS 57729-86-9
Catalog number: 57729-86-9
Category: Main Product
Molecular Formula:
C13H5Br3F3N3O4
Molecular Weight:
563.90
COA:
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Purity:
95%
Appearance:
Dark Brown Solid
Synonyms:
2,4-Dinitro-N-(2,4,6-tribromophenyl)-6-(trifluoromethyl)benzenamine;
MSDS:
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Application:
A metabolite of Bromethalin rodenticide found in the blood and liver of treated animals.
Quantity:
Data not available, please inquire.
Boiling Point:
438.1ºC at 760 mmHg
Density:
2.158g/cm3
InChIKey:
INVHIPJJDSPNJY-UHFFFAOYSA-N
InChI:
InChI=1S/C13H5Br3F3N3O4/c14-5-1-8(15)12(9(16)2-5)20-11-7(13(17,18)19)3-6(21(23)24)4-10(11)22(25)26/h1-4,20H
Canonical SMILES:
C1=C(C=C(C(=C1[N+](=O)[O-])NC2=C(C=C(C=C2Br)Br)Br)C(F)(F)F)[N+](=O)[O-]
1.The toxicity and mechanism of action of bromethalin: a new single-feeding rodenticide.
van Lier RB1, Cherry LD. Fundam Appl Toxicol. 1988 Nov;11(4):664-72.
Bromethalin is a new rodenticide for the control of commensal rodents. Doses in excess of the LD50 (2 mg/kg in rats) will cause death within 8-12 hr and it is preceded by one to three episodes of clonic convulsions with death usually due to respiratory arrest. Multiple low doses or sublethal intoxication yields hind leg weakness and loss of tactile sensation in rodents. Histopathology of the brain and spinal cord of these animals revealed a spongy degeneration of the white matter which was shown upon ultramicroscopic examination to be intramyelenic edema. No inflammation or cellular destruction of neuronal tissue was noted. LD50 values ranged from 1.8 mg/kg in the cat to approximately 13 mg/kg in rabbits. The only apparent nonsusceptible species was the guinea pig which could tolerate doses in excess of 1000 mg/kg without effect. Identification of the desmethyl metabolite was demonstrated in the blood and liver of treated animals by comparison of chromatographic retention times to that of a reference standard, but direct mass spectral identification was unsuccessful in part due to the low dose which could be administered.
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CAS 57729-86-9 Desmethyl Bromethalin

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