Desmethoxyyangonin - CAS 15345-89-8
Catalog number: 15345-89-8
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
Molecular Weight:
Monoamine Oxidase B
Desmethoxyyangonin, the microsomal metabolite of Yangonin (Y100550), reversibly inhibits of MAO-B.
White solid powder
4-methoxy-6-[(E)-2-phenylethenyl]pyran-2-one Desmethoxyyangonin 5,6-Dehydrokawain Demethoxyyangonin 15345-89-8 Desmethoxy Yangonin 5,6-Dehydrokavain (E)-4-Methoxy-6-styryl-2H-pyran-2-one trans-5,6-Dehydrokawain NSC 112161 CHEBI:1995 2H-Pyran-2-one, 4-meth
Soluble in DMSO
Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -67℃ for long term (months to years).
inhibitor of MAO-B
Quality Standard:
Enterprise Standard
Shelf Life:
2 years
Boiling Point:
440.00 °C at 760.00 mm Hg (est)
Melting Point:
133-134 °C
1.18±0.1 g/cm3
Canonical SMILES:
1.5,6-Dehydrokawain from Alpinia zerumbet promotes osteoblastic MC3T3-E1 cell differentiation.
Kumagai M1,2, Mishima T1, Watanabe A1, Harada T1, Yoshida I1, Fujita K1, Watai M1, Tawata S3, Nishikawa K2, Morimoto Y2. Biosci Biotechnol Biochem. 2016 Mar 4:1-8. [Epub ahead of print]
Bone homeostasis is maintained by balancing bone formation and bone resorption, but an imbalance between them is associated with various bone-related diseases such as osteoporosis and rheumatoid arthritis. We found that 5,6-dehydrokawain (DK) and dihydro-5,6-dehydrokawain (DDK), which were isolated as promising compounds from Alpinia zerumbet rhizomes, promote differentiation of osteoblastic MC3T3-E1 cells. DK and DDK increased the alkaline phosphatase activity and matrix mineralization of MC3T3-E1 cells. DK exerts larger effects than DDK. The gene expression of runt-related transcription factor 2 and osterix, which are essential transcription factors in the early period of osteoblast differentiation, was significantly increased by DK treatment. The mRNA level of distal-less homeobox 5 was also enhanced by DK treatment, and DK activated the p38 mitogen-activated protein kinase pathway. Therefore, DK may have clinical potential for preventing osteoporosis, and could be considered as a potential anabolic therapeutic agent.
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Chemical Structure

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