Deserpidine - CAS 131-01-1
Catalog number:
131-01-1
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C32H38N2O8
Molecular Weight:
578.66
COA:
Inquire
Targets:
Angiotensin-converting Enzyme (ACE)
Description:
Deserpidine is an antihypertensive drug related to Reserpine. It is naturally found in Rauvolfia spp. Deserpidine is a competitive ACE (angiotensin converting enzyme) inhibitor. Deserpidine can block the conversion of angiotensin I to angiotensin II as a potent vasoconstrictor through competing with angiotensin I for ACE. Reduced level of serum angiotensin II leads to a decrease in blood pressure. Deserpidine can also decrease angiotensin II-induced aldosterone secretion by the adrenal cortex.
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Purity:
95%
Appearance:
White solid
Synonyms:
(3β,16β,17α,18β,20α)-17-methoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylic Acid Methyl Ester; Deserpidic Acid Methyl Ester 3,4,5-Trimethoxybenzoate; Deserpidin; 1-Demethoxyreserpine; 11-Desmethoxyreserpine; Canescin; Canescine; Canescine (Rauwolfia); Harmonyl; NSC 72138; Raunormin; Raunormine; Recanescin; Recanescine; Reserpidine;
Solubility:
Chloroform (Slightly), Methanol (Slightly)
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
antihypertensive drug
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
Boiling Point:
676.1ºC at 760 mmHg
Melting Point:
223-226°C
Density:
1.32 g/cm3
InChIKey:
CVBMAZKKCSYWQR-WCGOZPBSSA-N
InChI:
InChI=1S/C32H38N2O8/c1-37-24-12-17(13-25(38-2)29(24)39-3)31(35)42-26-14-18-16-34-11-10-20-19-8-6-7-9-22(19)33-28(20)23(34)15-21(18)27(30(26)40-4)32(36)41-5/h6-9,12-13,18,21,23,26-27,30,33H,10-11,14-16H2,1-5H3/t18-,21+,23-,26-,27+,30+/m1/s1
Canonical SMILES:
COC1C(CC2CN3CCC4=C(C3CC2C1C(=O)OC)NC5=CC=CC=C45)OC(=O)C6=CC(=C(C(=C6)OC)OC)OC
1.[Clinical laboratory study of essential hypertension patients treated with a methylclothiazide deserpidine combination].
da Rocha AL, Saldanha RV. Hospital (Rio J). 1968 Oct;74(4):1299-304.
2.Comparison of the effectiveness of deserpidine, reserpine, and alpha-methyltyrosine on brain biogenic amines.
Fulton SC, Healy MD. Fed Proc. 1976 Dec;35(14):2558-62.
3.Antibody specificity studies for reserpine, its metabolites, and synthetic reserpine congeners: radioimmunoassay.
Loeffler LJ, Schran HF. J Pharm Sci. 1979 Nov;68(11):1433-5.
Progress in the development of radioimmunoassay techniques for reserpine and related compounds is reported. A conjugate of reserpine with human serum albumin was prepared, involving linkage at the indole nitrogen atom of reserpine. Injection of the purified conjugate into sheep elicited antibodies of high titer, which bound reserpine selectively. Tritiated reserpine was employed in the procedure, and dextran-coated charcoal was utilized to separate free and bound forms of the drug. Antibodies exhibited a selectivity for reserpine and did not cross-react significantly with major human metabolites. Cross-reactivity of antibodies with other reserpine derivatives (i.e., syrosingopine, deserpidine, and rescinnamine) also was investigated. A stable tritiated or radioiodinated reserpine derivative of high specific activity is being sought to improve assay sensitivity for use in bioequivalence and bioavailability studies. In the absence of any extraction or concentration procedures, at least a 10-fold increase in immunoassay sensitivity would be required to follow reserpine levels in humans given normal doses of the drug.
4.Deserpidine antagonism by a tripeptide, L-prolyl-L-leucyglycinamide.
Plotnikoff NP, Kastin AJ, Anderson MS, Schally AV. Neuroendocrinology. 1973;11(1):67-71.
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CAS 131-01-1 Deserpidine

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