Deoxycholic Acid - CAS 83-44-3
Catalog number:
83-44-3
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
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Description:
Deoxycholic acid, also known as deoxycholate, cholanoic acid, and 3α,12α-dihydroxy-5β-cholanate, is a bile acid. Deoxycholic acid is one of the secondary bile acids, which are metabolic byproducts of intestinal bacteria. Deoxycholic acid is soluble in alcohol and acetic acid. When pure, it comes in a white to off-white crystalline powder form.
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Purity:
0.98
Appearance:
white to off-white solid powder
Synonyms:
Deoxycholic acid; deoxycholate; cholanoic acid; 3α,12α-dihydroxy-5β-cholanate; 7-Deoxycholic acid, Desoxycholic acid. DCA.
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1. Salts of (+)-deoxycholic acid with amines: structure, thermal stability, kinetics of salt formation, decomposition and chiral resolution
Ayesha Jacobs,* Nikoletta B. Ba ´thori, Luigi R. Nassimbeni and Baganetsi K. Sebogisi. CrystEngComm, 2013, 15, 931–939
(+)-Deoxycholic acid forms salts with the achiral and chiral amines studied, via proton transfer from the carboxylic moiety of the host to the nitrogen of the amine guest. We achieved diastereomeric resolution of racemic mixtures of sec-butylamine and 3-methyl-2-butylamine. Crystallisation of racemic sec-butylamine and (+)-deoxycholic acid gave the (R)-enantiomer in the crystal structure. An analogous experiment with racemic 3-methyl-2-butylamine yielded exclusively crystals containing the (S)-enantiomer. The structures obtained from crystallisation of (+)-deoxycholic acid in (R)-sec-butylamine and (S)-sec-butylamine, respectively, were analysed and indicated similar hydrogen bonding patterns but significant differences in the H…H interactions.
2. Novel self-assembled amphiphilic mPEGylated starch-deoxycholic acid polymeric micelles with pH-response for anticancer drug delivery
Jinlong Yang, Chunmei Gao, Mingzhu Liu*. RSC Adv.,2014, 4,55139–55149
Deoxycholic acid (DCA), a main component of bile acid, is biologically the most detergent-like molecules, which plays a key role in the emulsification, solubilization and absorption of cholestrol, fat and vitamins in the body. In the precious reports, we have prepared a series of hydrophobically modified starch by the introduction of deoxycholic acid to form self-aggregates, but the DS of DCA was obviously low, because starch was not further modified to improve solubility.
3. Inverse thermally reversible gelation-based hydrogels: synthesis and characterization of N-isopropylacrylamide copolymers containing deoxycholic acid in the side chain
Yan Lu,* Yuqiao Han, Jinhuan Liang, Chenxi Li*. Polym. Chem., 2011, 2, 1866–1871
The peaks at 0.68, 0.92 and 1.01 ppmbelong to themethyl protons at positions 18, 19 and 21 of the deoxycholic acid skeleton within methylacrylate comonomer, respectively, increasing steadily with the content of the comonomer MEDCA increases in the copolymers. The peaks at 1.15 and 4.02 ppm correspond to the methyl and methane protons of the isopropyl group within NIPAM, respectively. The integration of the characteristic peaks can be used to calculate their chemical compositions. Herein, the composition of the copolymers was determined by the integration ratio of peak area of the proton signals from –CH within isopropyl group relative to that of the proton signals from the methyl group at position 18 of the deoxycholic acid skeleton in the copolymer. The calculated results presented in Table 1 show that the chemical compositions of the copolymers are very close to the original monomer compositions in the feed prior to polymerization.
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CAS 83-44-3 Deoxycholic Acid

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