Deltarasin hydrochloride - CAS 1440898-82-7
Catalog number: 1440898-82-7
Category: Inhibitor
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Molecular Formula:
C40H38ClN5O
Molecular Weight:
640.22
COA:
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Targets:
Phosphodiesterase (PDE)
Description:
Small molecule inhibitor of the KRAS–PDEδ interaction that impairs oncogenic KRAS signalling by altering its localization to endomembranes (in cell Kd value 41 nM for deltarasin binding to PDEδ). Deltarasin suppresses in vitro and in vivo MAPK signaling and proliferation of human pancreatic ductal adenocarcinoma (PDAC) cells that are dependent on oncogenic KRAS.
Purity:
>98%
Synonyms:
Deltarasin hydrochloride
MSDS:
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InChIKey:
NCIOVAYUMQEQEU-VKZSUDIWSA-N
InChI:
InChI=1S/C40H37N5O.3ClH/c1-3-11-29(12-4-1)27-44-36-17-9-7-15-34(36)42-39(44)32-19-21-33(22-20-32)46-28-38(30-23-25-41-26-24-30)45-37-18-10-8-16-35(37)43-40(45)31-13-5-2-6-14-31;;;/h1-22,30,38,41H,23-28H2;3*1H/t38-;;;/m1.../s1
Canonical SMILES:
C1CNCCC1C(COC2=CC=C(C=C2)C3=NC4=CC=CC=C4N3CC5=CC=CC=C5)N6C7=CC=CC=C7N=C6C8=CC=CC=C8.Cl.Cl.Cl
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CAS 1440898-82-7 Deltarasin hydrochloride

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