Delavirdine mesylate - CAS 147221-93-0
Catalog number: 147221-93-0
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C23H32N6O6S2
Molecular Weight:
552.67
COA:
Inquire
Targets:
HIV
Description:
Delavirdine is a non-nucleoside reverse transcriptase inhibitor (NNRTI). It is used as part of highly active antiretroviral therapy (HAART) for the treatment of human immunodeficiency virus (HIV) type 1.
Purity:
>98%
Synonyms:
Rescriptor; U 90152
MSDS:
Inquire
InChIKey:
MEPNHSOMXMALDZ-UHFFFAOYSA-N
InChI:
InChI=1S/C22H28N6O3S.CH4O3S/c1-15(2)24-19-5-4-8-23-21(19)27-9-11-28(12-10-27)22(29)20-14-16-13-17(26-32(3,30)31)6-7-18(16)25-20;1-5(2,3)4/h4-8,13-15,24-26H,9-12H2,1-3H3;1H3,(H,2,3,4)
Canonical SMILES:
CC(C)NC1=C(N=CC=C1)N2CCN(CC2)C(=O)C3=CC4=C(N3)C=CC(=C4)NS(=O)(=O)C.CS(=O)(=O)O
1. Clinical Implications of CNS Penetration of Antiretroviral Drugs
Heather E. Wynn, Richard C. Brundage and Courtney V. Fletcher. CNS Drugs 2002; 16 (9): 595-609
Delavirdine mesylate, nevirapine and efavirenz are the three currently marketed NNRTIs. As mentioned in section 2, the plasma protein binding of this class of agents varies, from>95%for delavirdine mesylate and efavirenz to approximately 60% for nevirapine. There are limited published data on the CSF penetration of this class of compounds (table II). Of the three available NNRTIs, delavirdine mesylate is the least often used in routine clinical practice because of its inconvenient administration schedule and toxicity profile. The available clinical data on CSF penetration focus on nevirapine and efavirenz. In clinical studies, both nevirapine and efavirenz are detected in the CSF up to 20 hours postdose as a result of their long elimination half-lives. For both antivirals, the CSF concentrations are variable and display a time-dependent decrease. In contrast, the CSF-to-plasma concentration ratios increase over the duration of the dose interval, a reflection of faster elimination from the central compartment.
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CAS 147221-93-0 Delavirdine mesylate

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