Delavirdine mesylate - CAS 147221-93-0
Catalog number: 147221-93-0
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C23H32N6O6S2
Molecular Weight:
552.67
COA:
Inquire
Targets:
HIV
Description:
Delavirdine is a non-nucleoside reverse transcriptase inhibitor (NNRTI). It is used as part of highly active antiretroviral therapy (HAART) for the treatment of human immunodeficiency virus (HIV) type 1.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
Synonyms:
Rescriptor; U 90152
MSDS:
Inquire
1. Clinical Implications of CNS Penetration of Antiretroviral Drugs
Heather E. Wynn, Richard C. Brundage and Courtney V. Fletcher. CNS Drugs 2002; 16 (9): 595-609
Delavirdine mesylate, nevirapine and efavirenz are the three currently marketed NNRTIs. As mentioned in section 2, the plasma protein binding of this class of agents varies, from>95%for delavirdine mesylate and efavirenz to approximately 60% for nevirapine. There are limited published data on the CSF penetration of this class of compounds (table II). Of the three available NNRTIs, delavirdine mesylate is the least often used in routine clinical practice because of its inconvenient administration schedule and toxicity profile. The available clinical data on CSF penetration focus on nevirapine and efavirenz. In clinical studies, both nevirapine and efavirenz are detected in the CSF up to 20 hours postdose as a result of their long elimination half-lives. For both antivirals, the CSF concentrations are variable and display a time-dependent decrease. In contrast, the CSF-to-plasma concentration ratios increase over the duration of the dose interval, a reflection of faster elimination from the central compartment.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related HIV Products


CAS 269055-15-4 Etravirine

Etravirine
(CAS: 269055-15-4)

Etravirine (ETR, brand name Intelence, formerly known as TMC125) is a drug used for the treatment of HIV. Etravirine is a non-nucleoside reverse transcriptase i...

CAS 1155419-89-8 BI 224436

BI 224436
(CAS: 1155419-89-8)

BI 224436 is a novel HIV-1 non-catalytic-site integrase inhibitor; has antiviral EC50s of <15 nM against different HIV-1 laboratory strains and cellular cytotox...

CAS 161814-49-9 Amprenavir

Amprenavir
(CAS: 161814-49-9)

Amprenavir promotes the specific interactions between the nuclear receptor pregnane X receptor (PXR) and the coactivators SRC-1 and PBP.

CAS 864953-29-7 BMS-663068

BMS-663068
(CAS: 864953-29-7)

BMS-663068 is an HIV-1 attachment inhibitor in development for the treatment of HIV-1 infection. It is a prodrug for BMS-626529, which binds to the viral envelo...

CAS 174484-41-4 Tipranavir

Tipranavir
(CAS: 174484-41-4)

Tipranavir, a nonpeptidic HIV protease inhibitor (NPPI), inhibits the enzymatic activity and dimerization of HIV-1 protease, exerts potent activity against mult...

CAS 144217-65-2 YYA-021

YYA-021
(CAS: 144217-65-2)

YYA-021 enhances the neutralization sensitivity of simian-human immunodeficiency virus (SHIV) carrying the envelope from the clade B clinical human immunodefici...

CAS 134624-73-0 Stavudine sodium

Stavudine sodium
(CAS: 134624-73-0)

Stavudine sodium is a dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV. Stavudine sodium is an analog of thymi...

CAS 159989-64-7 Nelfinavir

Nelfinavir
(CAS: 159989-64-7)

Nelfinavir is a HIV protease inhibitor; antiretroviral; and anti-tumor agent.

CAS 313682-08-5 Brecanavir

Brecanavir
(CAS: 313682-08-5)

Brecanavir is a tyrosyl-based arylsulfonamide, high-affinity, protease inhibitor (PI) for the treatment of human immunodeficiency virus type-1. This compound po...

BMS585248
(CAS: 619331-12-3)

BMS585248 is a highly potent and novel human immunodeficiency virus type 1 (HIV-1) attachment inhibitor with 4-fluoro-6-azaindole core heterocycles. It targets ...

CAS 869901-69-9 MK-2048

MK-2048
(CAS: 869901-69-9)

MK-2048 is a second generation integrase inhibitor (IC50=2.6 nM). It can inhibits the HIV enzyme integrase 4 times longer than raltegravir.

CAS 155213-67-5 Ritonavir

Ritonavir
(CAS: 155213-67-5)

Ritonavir is a very potent inhibitor of CYP3A4 mediated testosterone 6β-hydroxylation with mean Ki of 19 nM and also inhibits tolbutamide hydroxylation with IC5...

CAS 106362-32-7 Peptide T

Peptide T
(CAS: 106362-32-7)

Peptide T is an HIV entry inhibitor that acts by blocking chemokine-5 receptors (CCR5), currently under clinical trials for the treatment of HIV-related neurolo...

CAS 729607-74-3 BMS-707035

BMS-707035
(CAS: 729607-74-3)

BMS-707035 is a specific HIV-I integrase (IN) inhibitor with IC50 of 15 nM.

CAS 229975-97-7 Atazanavir Sulfate

Atazanavir Sulfate
(CAS: 229975-97-7)

Atazanavir is a HIV protease inhibitor with Ki of 2.66 nM. It is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is ...

CAS 149845-06-7 Saquinavir Mesylate

Saquinavir Mesylate
(CAS: 149845-06-7)

Saquinavir is an HIV Protease Inhibitor used in antiretroviral therapy. It inhibits both HIV-1 and HIV-2 proteases. Studies have also looked at saquinavir as a ...

CAS 62956-48-3 Gomisin G

Gomisin G
(CAS: 62956-48-3)

Gomisin G, carboxylic acid with additional oxygen functions, exhibited the most potent anti-HIV activity with EC50 and therapeutic index (TI) values of 0.006 mi...

PD 134922
(CAS: 150351-30-7)

PD 134922 has been found to be a HIV-1 protease inhibitor that could probably be effective against HIV infections.

CAS 871038-72-1 Raltegravir

Raltegravir
(CAS: 871038-72-1)

Raltegravir is a potent, selective, and orally bioavailable inhibitor of HIV integrase (IC50 = 15 nM). It is metabolized primarily by uridine diphosphate glucur...

Censavudine
(CAS: 634907-30-5)

Censavudine is a nucleoside reverse transcriptase inhibitor. It is active against HIV resistant to both abacavir and tenofovir. It is a candidate for people wit...

Chemical Structure

CAS 147221-93-0 Delavirdine mesylate

Quick Inquiry

Verification code

Featured Items