Dehydrocorydaline - CAS 30045-16-0
Catalog number:
30045-16-0
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C22H24NO4
Molecular Weight:
366.44
COA:
Inquire
Targets:
Others
Description:
Dehydrocorydaline, an alkaloid derived from the tubers of Corydalis ambigua, with potential anti-tumor activity it significantly inhibits MCF-7 cell proliferation in a dose- dependent manner.
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Purity:
>98%
Appearance:
Solid powder
Synonyms:
2,3,9,10-tetramethoxy-13-methyl-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium dehydrocorydalin dehydrocorydalin chloride dehydrocorydaline
Solubility:
Soluble in DMSO
Storage:
Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -57℃ for long term (months to years).
MSDS:
Inquire
Application:
analgesia
Quality Standard:
Enterprise Standard
Shelf Life:
2 years
Quantity:
Milligrams-Grams
Melting Point:
170-173 °C
InChIKey:
RFKQJTRWODZPHF-UHFFFAOYSA-N
InChI:
1S/C22H24NO4/c1-13-15-6-7-18(24-2)22(27-5)17(15)12-23-9-8-14-10-19(25-3)20(26-4)11-16(14)21(13)23/h6-7,10-12H,8-9H2,1-5H3/q+1
Canonical SMILES:
CC1=C2C=CC(=C(C2=C[N+]3=C1C4=CC(=C(C=C4CC3)OC)OC)OC)OC
1.LC-MS/MS determination and pharmacokinetic study of dehydrocorydaline in rat plasma after oral administration of dehydrocorydaline and Corydalis yanhusuo extract.
Li QY1, Li KT2, Sun H3, Jin W4, Shi JW5, Shi Y6. Molecules. 2014 Oct 13;19(10):16312-26. doi: 10.3390/molecules191016312.
A rapid, sensitive and selective liquid chromatography/tandem mass spectrometry method (LC-MS/MS) was developed and validated for determination of dehydrocorydaline (DHC) in rat plasma using nitidine chloride as an internal standard. The analytes were solid-phase extracted and eluted on a C18 chromatography column using a mobile phase of acetonitrile and water (containing 0.8% formic acid and 10 mM ammonium acetate) (28:72, v/v). Detection was performed using positive ion electrospray ionization in multiple reaction monitoring modes. The assay was linear over the concentration range 0.625-250 ng/mL with a quantification limit of 0.625 ng/mL. The precision was <13.7%, the accuracy >93.1%, and extraction recovery ranged from 92.1% to 107%. The validated method was successfully applied to the pharmacokinetics and excretion study of DHC in rat plasma after oral administration of pure DHC and an effective fraction of Corydalis yanhusuo (EFY).
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CAS 30045-16-0 Dehydrocorydaline

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