Dehydroandrographolide - CAS 134418-28-3
Catalog number:
134418-28-3
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C20H28O4
Molecular Weight:
332.43
COA:
Inquire
Targets:
Others
Description:
Dehydroandrographolide is a natural diterpenoid found in Andrographis paniculata. It possesses activity against hepatitis B virus DNA replication.
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Purity:
>98%
Appearance:
White powder
Synonyms:
Andrographolide, dehydro-;Deoxy-11,12-didehydroandrographolide;(3E)-3-[2-[(1S,4aS,5R,6R,8aS)-Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]-2(3H)-furanone;14-Deoxy-11-dehydroandrographolide
Solubility:
10 mM in ethanol
Storage:
-20ºC Freeze
MSDS:
Inquire
Application:
Dehydroandrographolide is a natural diterpenoid found in Andrographis paniculata and possesses activity against hepatitis B virus DNA replication.
Quality Standard:
Enterprise Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Grams-Kilos
InChIKey:
YIIRVUDGRKEWBV-CZUXAOBFSA-N
InChI:
InChI=1S/C20H28O4/c1-13-4-7-16-19(2,10-8-17(22)20(16,3)12-21)15(13)6-5-14-9-11-24-18(14)23/h5,9,11,15-17,21-22H,1,4,6-8,10,12H2,2-3H3/b14-5+/t15-,16-,17+,19-,20-/m0/s1
Canonical SMILES:
CC12CCC(C(C1CCC(=C)C2CC=C3C=COC3=O)(C)CO)O
1.Potassium dehydroandrographolide succinate injection for treat- ment of infantile pneumonia: a systematic review and Meta-analysis.
Xiaomeng Z, Jiarui W, Bing Z, Ling D. J Tradit Chin Med. 2015 Apr;35(2):125-33.
OBJECTIVE: To evaluate systematically the clinical efficacy and safety of potassium dehydroandrographolide succinate injection (PDS) in treatment of infantile pneumonia.
2.Simultaneous determination of andrographolide, dehydroandrographolide and neoandrographolide in dog plasma by LC-MS/MS and its application to a dog pharmacokinetic study of Andrographis paniculata tablet.
Xu FF1, Fu SJ2, Gu SP3, Wang ZM4, Wang ZZ5, He X6, Xiao W7. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 May 15;990:125-31. doi: 10.1016/j.jchromb.2015.03.014. Epub 2015 Mar 30.
In this study, a sensitive and rapid liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated to simultaneously determinate andrographolide (AP), dehydroandrographolide (DP), and neoandrographolide (NP) in plasma of beagle dogs after oral administration of Andrographis paniculata tablet (A. paniculata). The analytes and bilobalide (internal standard) were separated on an Agilent ZORBAX XDB-C18 column (50mm×2.1mm, 3.5μm) by using gradient elution consisting of methanol and water at a flow rate of 0.50mL/min in 7min. Multiple reaction monitoring (MRM) mode was performed to quantify data under monitoring precursor-product ion transitions of m/z 348.8→286.9, 330.9→107.9, 479.1→160.8 and 325.0→163.0 for AP, DP, NP and internal standard (IS) at negative ion mode, respectively. This method was developed at linearity ranging from 0.50 to 250ng/mL for AP, 1.00 to 500ng/mL for DP and 0.20 to 100ng/mL for NP. The accuracy of each analyte ranged between 94.
3.Dehydroandrographolide, an iNOS inhibitor, extracted from Andrographis paniculata (Burm.f.) Nees, induces autophagy in human oral cancer cells.
Hsieh MJ1,2,3, Lin CW4,5, Chiou HL6,7, Yang SF3,8, Chen MK9. Oncotarget. 2015 Oct 13;6(31):30831-49. doi: 10.18632/oncotarget.5036.
Autophagy, which is constitutively executed at the basal level in all cells, promotes cellular homeostasis by regulating the turnover of organelles and proteins. Andrographolide and dehydroandrographolide (DA) are the two principle components of Andrographis paniculata (Burm.f.) Nees. and are the main contributors to its therapeutic properties. However, the pharmacological activities of dehydroandrographolide (DA) remain unclear. In this study, DA induces oral cancer cell death by activating autophagy. Treatment with autophagy inhibitors inhibited DA-induced human oral cancer cell death. In addition, DA increased LC3-II expression and reduced p53 expression in a time- and concentration-dependent manner. Furthermore, DA induced autophagy and decreased cell viability through modulation of p53 expression. DA-induced autophagy was triggered by an activation of JNK1/2 and an inhibition of Akt and p38. In conclusion, this study demonstrated that DA induced autophagy in human oral cancer cells by modulating p53 expression, activating JNK1/2, and inhibiting Akt and p38.
4.Dehydroandrographolide enhances innate immunity of intestinal tract through up-regulation the expression of hBD-2.
Xiong WB1, Shao ZJ2, Xiong Y2, Chen J2, Sun Y2, Zhu L3, Zhou LM4. Daru. 2015 Jul 30;23:37. doi: 10.1186/s40199-015-0119-4.
BACKGROUND: Dehydroandrographolide (DA) is one of major active components in the well-known oriental herbal medicine Andrographis paniculata (Burm.f) Nees which belongs to the Acanthaceae family. DA is used for the treatment of infections in China. However, DA has not been found to significantly inhibit bacterial and viral growth directly. The current study investigates the effect of DA on the expression of human β -defensin-2 (hBD-2) in human intestinal epithelial cells and the possible signaling pathways.
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CAS 134418-28-3 Dehydroandrographolide

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