Deflazacort - CAS 14484-47-0
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Not Intended for Therapeutic Use. For research use only.
Glucocorticoid Receptor
Deflazacort is a glucocorticoid used as an anti-inflammatory and immunosuppressant.
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Cortax, Decortil, and Deflanil, Flezacor.
1.Ultra-structural time-course study in the C. elegans model for Duchenne muscular dystrophy highlights a crucial role for sarcomere-anchoring structures and sarcolemma integrity in the earliest steps of the muscle degeneration process.
Brouilly N1, Lecroisey C1, Martin E1, Pierson L1, Mariol MC1, Qadota H2, Labouesse M3, Streichenberger N4, Mounier N1, Gieseler K5. Hum Mol Genet. 2015 Nov 15;24(22):6428-45. doi: 10.1093/hmg/ddv353. Epub 2015 Sep 10.
Duchenne muscular dystrophy (DMD) is a genetic disease characterized by progressive muscle degeneration due to mutations in the dystrophin gene. In spite of great advances in the design of curative treatments, most patients currently receive palliative therapies with steroid molecules such as prednisone or deflazacort thought to act through their immunosuppressive properties. These molecules only slightly slow down the progression of the disease and lead to severe side effects. Fundamental research is still needed to reveal the mechanisms involved in the disease that could be exploited as therapeutic targets. By studying a Caenorhabditis elegans model for DMD, we show here that dystrophin-dependent muscle degeneration is likely to be cell autonomous and affects the muscle cells the most involved in locomotion. We demonstrate that muscle degeneration is dependent on exercise and force production. Exhaustive studies by electron microscopy allowed establishing for the first time the chronology of subcellular events occurring during the entire process of muscle degeneration.
2.Deflazacort Versus Prednisolone: Randomized Controlled Trial in Treatment of Children With Idiopathic Nephrotic Syndrome.
Singhal R1, Pandit S1, Dhawan N1. Iran J Pediatr. 2015 Apr;25(2):e510. doi: 10.5812/ijp.510. Epub 2015 Apr 18.
BACKGROUND: Corticosteroids are the main therapy of nephrotic syndrome and goal of corticosteroid therapy is to obtain maximum clinical benefit with minimum adverse effects. Children are more vulnerable to side effects of corticosteroids related to growth and adrenal suppression, so a search for an alternative steroid with fewer side-effects is underway. Deflazacort is an oxazoline derivative and preliminary data suggest reduced osteoporosis, lesser growth retardation and weight gain with deflazacort.
3.Practice guideline update summary: Corticosteroid treatment of Duchenne muscular dystrophy: Report of the Guideline Development Subcommittee of the American Academy of Neurology.
Gloss D1, Moxley RT 3rd1, Ashwal S1, Oskoui M1. Neurology. 2016 Feb 2;86(5):465-72. doi: 10.1212/WNL.0000000000002337.
OBJECTIVE: To update the 2005 American Academy of Neurology (AAN) guideline on corticosteroid treatment of Duchenne muscular dystrophy (DMD).
4.Efficiency of hyperbaric oxygen and steroid therapy in treatment of hearing loss following acoustic trauma.
Salihoğlu M, Ay H, Cincik H, Cekin E, Cesmeci E, Memis A, Uzun G, Altundag A, Simsek K. Undersea Hyperb Med. 2015 Nov-Dec;42(6):539-46.
INTRODUCTION: Most commonly used treatment modalities for acute acoustic trauma (AAT) include steroid and hyperbaric oxygen (HBO2) therapy. The aim of this study is to investigate the effectiveness of combined steroid and HBO2 therapy in patients who develop AAT during firearms training and the effect of delay to treatment on treatment success.
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CAS 14484-47-0 Deflazacort

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