|Molecular Formula||C9H16N3O12P3S (free acid)|
|Molecular Weight||483.22 (free acid)|
|Structure\Application||Phosphate modified Nucleotides|
|Purity||≥ 95% by HPLC|
|Appearance||clear aqueous solution|
|Synonyms||2'-Deoxycytidine-5'-(α-thio)-triphosphate, Sodium salt (1 : 1 Mixture of Rp and Sp isomers)|
GTPαS can be accomplished by 50-thiophosphorylation of 7-methylguanosine in (MeO)3PO in the presence of 2,6-lutidine,12 followed by addition of tributylammonium...
Sp-2'-O-Me-GTP-α-S is an analogue of GTP that can be used for enzymatic introduction of phosphorothioate and modified 2'-OH groups into RNA.
GTPγS is a stable G-protein-activating (GTP) analog. The physiological actions of GTPgammaS includestimulation of guanine nucleotide-binding proteins, phosphoin...
ddUTP-α-S is used in mass spectrometric genotyping.
Mant-GTPγS had lower affinities for Gαs and Gαi than GTPγS/GppNHp as assessed by inhibition of GTP hydrolysis of receptor-Gα fusion proteins. MANT-GTPγS was muc...
6-cPe-ATP-γ-S is an analogue used to specifically interact with modified receptor proteins (chemical genetics approach).