|Description||Darifenacin hydrobromide is an antispasmodic muscarinic antagonist, selective for blocking the M3 muscarinic acetylcholine receptor, which is primarily responsible for bladder muscle contractions. Darifenacin hydrobromide has 9 and 12-fold greater affinity for M3 compared to M1 and M5, respectively, and 59-fold greater affinity for M3 compared to both M2 and M4. Darifenacin is used clinically to treat urinary incontinence and overactive bladder syndrome.|
|Synonyms||UK-88525; UK 88525; UK88525|
Xanomeline is a Muscarinic M1 and M4 receptor agonist under the development of Eli Lilly, though it is also known to act as a M5 receptor antagonist. Xanomeline...
Methscopolamine is a muscarinic acetylcholine receptor blocker.
Isopropamide Iodide is an anticholinergic compound and a muscarinic receptor antagonist, which can be used for Alzheimer's disease treatment.
Arecaidine propargyl ester tosylate
Arecaidine propargyl ester tosylate is a potent muscarinic receptor agonist. It displays some selectivity for cardiac versus ileal M2 receptors.
Tarafenacin is a highly selective M3 muscarinic receptor antagonist (Ki=0.19 nM), ~200 fold selectivity over M2 receptor.
Zamifenacin is a Muscarinic M3 receptor antagonist originated by Pfizer. pKi value is 8.52 for M3 receptor, 7.93 for M2 receptor, 7.90 for M1 receptor and 7.78 ...
Camylofine is an antimuscarinic with both anticholinergic action as well as direct smooth muscle action. It can be used to treat the pain caused by smooth muscl...
W-84 dibromide is a potent allosteric modulator of muscarinic M2 receptors. W-84 dibromide has been shown to stabilize cholinergic antagonist-receptor complexes...