Daidzin - CAS 552-66-9
Catalog number: 552-66-9
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C21H20O9
Molecular Weight:
416.38
COA:
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Targets:
Others
Description:
Daidzin is a natural organic compound in the class of phytochemicals known as isoflavones.Daidzin has shown the potential for the treatment of alcohol dependency (antidipsotropic) based on animal models.
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Purity:
>98%
MSDS:
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1.Effect of linker length between variable domains of single chain variable fragment antibody against daidzin on its reactivity.
Yusakul G1, Sakamoto S1, Pongkitwitoon B2, Tanaka H1, Morimoto S1. Biosci Biotechnol Biochem. 2016 Apr 27:1-7. [Epub ahead of print]
The peptide linker between variable domains of heavy (VH) and light (VL) chains is one of important factors that influence the characteristics of scFv, including binding activity and specificity against target antigen. The scFvs against daidzin (DZ-scFvs) with different linker lengths were constructed in the format of VH-(GGGGS)n-VL (n = 1, 3, 5, and 7). They were expressed in the hemolymph of silkworm larvae using the Bombyx mori nucleopolyhedrovirus (BmNPV) bacmid DNA system, and their reactivity against daidzin and related compounds were evaluated using an indirect competitive enzyme-linked immunosorbent assay (icELISA), which is applicable for quantitative analysis of daidzin. The results showed that the reactivity of scFvs against daidzin was increased, whereas specificity slightly decreased when their peptide linker was lengthened. These results suggested that the linker length of DZ-scFvs contributes to its reactivity. In addition, the results emphasize that the linker length could control the reactivity of DZ-scFvs.
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CAS 552-66-9 Daidzin

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