Daclatasvir dihydrochloride - CAS 1009119-65-6
Catalog number:
1009119-65-6
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
COA:
Inquire
Targets:
HCV
Description:
Daclatasvir dihydrochloride is a highly selective inhibitor of HCV NS5A with EC50 of 9-50 pM, for a broad range of HCV replicon genotypes and the JFH-1 genotype 2a infectious virus in cell culture.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
Related CAS:
1009119-64-5 (Free base)
Appearance:
Solid powder
Synonyms:
methyl N-[(2S)-1-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]phenyl]phenyl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate dihydrochloride; Daclatasvir; BMS790052; BMS 790052; BMS-790052; EBP883; EBP 883; EBP-883; trade name Daklinza PubchemCID 25154714
MSDS:
Inquire
InChIKey:
BVZLLUDATICXCI-JMSCDMLISA-N
InChI:
1S/C40H50N8O6.2ClH/c1-23(2)33(45-39(51)53-5)37(49)47-19-7-9-31(47)35-41-21-29(43-35)27-15-11-25(12-16-27)26-13-17-28(18-14-26)30-22-42-36(44-30)32-10-8-20-48(32)38(50)34(24(3)4)46-40(52)54-6;;/h11-18,21-24,31-34H,7-10,19-20H2,1-6H3,(H,41,43)(H,42,44)(H,45,51)(H,46,52);2*1H/t31-,32-,33-,34-;;/m0../s1
Canonical SMILES:
O=C(OC)N[C@@H](C(C)C)C(N1[C@H](C2=NC=C(C3=CC=C(C4=CC=C(C5=CN=C([C@H]6N(C([C@@H](NC(OC)=O)C(C)C)=O)CCC6)N5)C=C4)C=C3)N2)CCC1)=O.[H]Cl.[H]Cl
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related HCV Products


CAS 1425038-27-2 MK-5172 sodium salt

MK-5172 sodium salt
(CAS: 1425038-27-2)

In biochemical assays, MK-5172 was effective against a panel of major genotypes and variants engineered with common resistant mutations observed in clinical stu...

CAS 958002-33-0 Beclabuvir

Beclabuvir
(CAS: 958002-33-0)

Beclabuvir is a potent, non-nucleotide inhibitor of HCV NS5B which is currently in Phase III clinical trials for the treatment of chronic HCV infection. Beclabu...

BMS-890068

BMS-890068 is an acyclic P1 bi-cyclopropaneacylsulfonamidetripeptide that can be used as hepatitis C virus (HCV) NS3 protease inhibitor.

CAS 1000787-75-6 Tegobuvir

Tegobuvir
(CAS: 1000787-75-6)

Tegobuvir is a non-nucleoside nonstructural protein (NS)5B polymerase inhibitor.

CAS 923604-59-5 Simeprevir

Simeprevir
(CAS: 923604-59-5)

Simeprevir plays an important role in HCV replication. Data from phase I and II clinical trials of TMC-435350 (TMC 435350; TMC 435; TMC-435350) to date have sho...

CAS 1502654-87-6 Ledipasvir D-tartrate

Ledipasvir D-tartrate
(CAS: 1502654-87-6)

Against JFH1/3a-NS5A, DCV was more potent (EC(50) = 0.52 nM) than GS-5885 (EC(50) = 141 nM). DCV sensitivity was increased against JFH1/3a-NS5A-M28V (EC50 = 0.0...

CAS 817204-33-4 PSI-6130

PSI-6130
(CAS: 817204-33-4)

PSI-6130 is a potent and selective inhibitor of HCV NS5B polymerase. It is metabolized to two pharmacologically active species in primary human hepatocytes.

Velpatasvir
(CAS: 1377049-84-7)

Velpatasvir is a selective Hepatitis C virus NS 5 protein inhibitor originated by Gilead Sciences. It has showed pan-genotypic activity and a high barrier to re...

CAS 63968-64-9 Artemisinin

Artemisinin
(CAS: 63968-64-9)

Artemisinin is a drug used to treat multi-drug resistant strains of falciparum malaria.

CAS 254435-95-5 Alisporivir

Alisporivir
(CAS: 254435-95-5)

Alisporivir, also known as DEB-025, a non-immunosuppressive cyclosporine A derivative, is acyclophil ininhibitor molecule with potent anti-hepatitis C virus (HC...

CAS 1026785-59-0 VX-222 (VCH-222, Lomibuvir)

VX-222 (VCH-222, Lomibuvir)
(CAS: 1026785-59-0)

VX-222 (VCH-222) is a novel, potent and selective inhibitor of HCV polymerase with IC50 of 0.94-1.2 μM, 15.3-fold less effective for mutant M423T, and 108-fold ...

CAS 1132935-63-7 dasabuvir

dasabuvir
(CAS: 1132935-63-7)

Dasabuvir is an antiviral drug for the treatment of hepatitis C. It inhibits hepatitis C virus (HCV) non-nucleoside NS5B palm polymerase to suppress RNA replica...

Ravidasvir HCl
(CAS: 1303533-81-4)

Avidasvir is a second-generation Hepatitis C virus NS 5 protein inhibitor. In Sep 2016, Phase-II/III clinical trials in Hepatitis C in Malaysia was on-going.

CAS 1350514-68-9 MK-5172

MK-5172
(CAS: 1350514-68-9)

In biochemical assays, MK-5172 was effective against a panel of major genotypes and variants engineered with common resistant mutations observed in clinical stu...

CAS 1009119-64-5 Daclatasvir

Daclatasvir
(CAS: 1009119-64-5)

Daclatasvir, inhibits the HCV protein NS5A, and thus can be used as a drug candidate for the treatment of hepatitis C (HCV).

CAS 394730-60-0 Boceprevir

Boceprevir
(CAS: 394730-60-0)

An NS3 serine protease inhibitor of hepatitis C virus, for the treatment of HCV infection.

CAS 1256388-51-8 Ledipasvir

Ledipasvir
(CAS: 1256388-51-8)

Ledipasvir (GS5885) is a HCV NS5A polymerase inhibitor, used for the treatment of hepatitis C virus infection.

CAS 1190307-88-0 sofosbuvir

sofosbuvir
(CAS: 1190307-88-0)

PSI-7977 is a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate and is currently being investiga...

CAS 442666-98-0 Anguizole

Anguizole
(CAS: 442666-98-0)

Anguizole is a small molecule inhibitor of HCV replication and alters NS4B's subcellular distribution.

CAS 691852-58-1 Nesbuvir

Nesbuvir
(CAS: 691852-58-1)

Nesbuvir, a novel selective nonstructural protein 5B (NS5B) polymerase inhibitor, acts as candidate for HCV treatment. It was reduced across different isolates.

Chemical Structure

CAS 1009119-65-6 Daclatasvir dihydrochloride

Quick Inquiry

Verification code

Featured Items