D-Pantothenic Acid Sodium Salt - CAS 867-81-2
Catalog number:
867-81-2
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C9H16NNaO5
Molecular Weight:
241.22
COA:
Inquire
Targets:
Others
Description:
D-Pantothenic acid sodium is a sodium salt form of the biologically active enantiomer of pantothenic acid, which is a precursor in the biosynthesis of coenzyme A. It is a water-soluble vitamin and an essential nutrient for for many animals. It is used to synthesize coenzyme-A (CoA) and synthesize and metabolize proteins, carbohydrates, and fats by animals.
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Purity:
99%
Appearance:
Solid powder
Synonyms:
Sodium D-pantothenate;N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-,monosodiumsalt,(R)-.beta.-Alanine;Sodium pantothenate;Vitamin B5 sodium;Sodium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate
Solubility:
H2O: 50 mg/mL
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
D-Pantothenic acid sodium is an essential nutrient for for many animals. It is used to synthesize coenzyme-A (CoA) and synthesize and metabolize proteins, carbohydrates, and fats by animals.
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Kilogram to ton
Boiling Point:
551.5ºC at 760 mmHg
Melting Point:
171-178 °C
InChIKey:
GQTHJBOWLPZUOI-FJXQXJEOSA-M
InChI:
InChI=1S/C9H17NO5.Na/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13;/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13);/q;+1/p-1/t7-;/m0./s1
Canonical SMILES:
CC(C)(CO)C(C(=O)NCCC(=O)[O-])O.[Na+]
1.Pressure-pulsed inhalation corticosteroid therapy in olfactory disorders: how we do it.
Fleiner F1, Lau L, Goektas O. Clin Otolaryngol. 2010 Oct;35(5):429-34. doi: 10.1111/j.1749-4486.2010.02199.x.
2.Fluorometric determination of pantothenic acid in human urine by isocratic reversed-phase ion-pair high-performance liquid chromatography with post-column derivatization.
Takahashi K1, Fukuwatari T, Shibata K. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Jul 15;877(22):2168-72. doi: 10.1016/j.jchromb.2009.05.056. Epub 2009 Jun 6.
We describe here a method for the determination of pantothenic acid, vitamin B(5), in human urine by isocratic reversed-phase ion-pair HPLC with post-column derivatization. Pantothenic acid in urine was separated using a Tosoh ODS-80Ts (4.6 i.d. x 250 mm) column with phosphate-sodium hydroxide buffer (pH 7.0) containing dodecyltrimethylammonium chloride. Following the isolation of pantothenic acid it was decomposed to pantoic acid and beta-alanine by alkali treatment. The product beta-alanine was post-derivatized to the fluorescent 1-alkylthio-2-alkylisoindole with orthophthaldialdehyde in the presence of 3-mercaptopropionic acid. In the proposed method, a urine sample can be directly injected into a HPLC system without any pre-clean up treatment. The limit of detection was 3 pmol (ca. 650 pg) per 20 microL of urine at a signal-to-noise ratio of 5:1 and the limit of quantification was 5 pmol (ca. 1000 pg) per 20 microL of urine, which was sufficiently sensitive for the determination of pantothenic acid in human urine.
3.Production of B-group vitamins by two Azotobacter strains with phenolic compounds as sole carbon source under diazotrophic and adiazotrophic conditions.
Revillas JJ1, Rodelas B, Pozo C, Martínez-Toledo MV, González-López J. J Appl Microbiol. 2000 Sep;89(3):486-93.
Azotobacter vinelandii strain ATCC 12837 and A. chroococcum strain H23 (CECT 4435) were able to grow on N-free or NH4Cl-amended chemically-defined (Burk's) media, with protocatechuic acid (1-2 mmol 1(-1)) or sodium p-hydroxybenzoate (1-10 mmol 1(-1)) as sole carbon (C) sources. At a concentration of 2 mmol 1(-1), both substrates supported nitrogen fixation (acetylene reduction assay) at similar or higher rates than bacteria grown in control media amended with 2 mmol 1(-1) sodium succinate as C source. The two strains produced the B-group vitamins niacin, pantothenic acid, thiamine, riboflavin and biotin after 72 h of growth in chemically-defined media with 2 mmol 1(-1) protocatechuic acid, sodium phydroxybenzoate or sodium succinate as sole C source, either in N-free media or in media amended with 0.1% NH4Cl. Quantitative production of all vitamins was affected by the use of the different C and N substrates.
4.Formulation and stability of a novel artificial human sweat under conditions of storage and use.
Harvey CJ1, LeBouf RF, Stefaniak AB. Toxicol In Vitro. 2010 Sep;24(6):1790-6. doi: 10.1016/j.tiv.2010.06.016. Epub 2010 Jul 3.
A limitation of most artificial sweat formulations used for in vitro assessment of chemical release from materials in contact with skin have little biological relevance to human sweat. The purposes of this paper are to provide guidance for preparation of a novel artificial sweat with chemical constituents at concentrations that match human sweat and to characterize chemical stability. The artificial sweat was characterized under conditions of use (with and without sebum at 36 degrees C) and storage (without sebum at -4, 4, and 23 degrees C) over 28 days by gas chromatography-mass spectroscopy, high-performance liquid chromatography, enzymatic assay kits, and ion-selective electrodes. Seven indicator constituents were tracked: sodium, chloride, glucose, lactic acid, urea, pantothenic acid, and alanine. With or without sebum at 36 degrees C, the sweat solvent was chemically stable for 14 days. Storage by refrigeration at 4 degrees C retained the chemical integrity of the solvent longest.
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CAS 867-81-2 D-Pantothenic Acid Sodium Salt

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