|Targets||Cytokine Receptor | NF-κB|
|Description||Neopterin, a pyrazino-pyrimidine compound derived from GTP, n is a precursor of tetrahydrobiopterin and can be used as a biochemical marker indicative of cell proliferation. Neopterin is synthesized in response to interferon-γ stimulation, and used as a marker of T helper cell-induced immune activation. Neopterin is also an indicator of oxidative stress, and modulates the effects of reactive oxygen species (ROS).|
|Purity||≥98% by HPLC|
|Synonyms||2-Amino-6-[(1S,2R)-1,2,3-trihydroxypropyl]-4(3H)-pteridinone; Neopterin; 2-Amino-4-hydroxy-6-(1,2,3-trihydroxypropyl)pteridine; 2-Amino-6-((1S,2R)-1,2,3-trihydroxypropyl)-4(8H)-pteridone; 6-D-erythro-Neopterin; D-(+)-Neopterin; D-erythro-Neopterin|
|Solubility||DMSO to 20 mM with gentle warming|
|Storage||Store in a cool and dry place (or refer to the Certificate of Analysis).|
CID-2858522 selectively inhibits the NF-κB pathway induced by PKC, operating downstream of PKC but upstream of IKKbeta, without inhibiting other NF-kappaB activ...
IL5 receptor antagonist
Harpagoside, isolated from the Harpagophytum procumbens (Devil's Claw) root or Crophularia ningpoensis Hemsl (Figwort), inhibited lipopolysaccharide-induced mRN...
Edasalonexent, also known as CAT-1004, is a NF-kappa B inhibitor under the development of Catabasis Pharmaceuticals and Sarepta Therapeutics. It is a Inflammati...
QNZ (EVP4593) shows potent inhibitory activity toward both NF-κB activation and TNF-α production with IC50 of 11 nM and 7 nM, respectively.
Recoflavone, also referred to DA 6034, is a synthetic flavonoid derivative known to possess anti-inflammatory activity in phase Ⅲ clinical trials for the treatm...
Lyn peptide inhibitor
Inhibits Lyn-dependent activities of IL-5 receptor; cell-permeable
(R)-alpha-Lipoic Acid, a vitamin-like organosulfur compound, is widely used as a dietary supplement and antioxidant. It has been also found to influence the act...