D-Cycloserine - CAS 68-41-7
Catalog number:
68-41-7
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C3H6N2O2
Molecular Weight:
102.09
COA:
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Targets:
Antibacterial
Description:
D-Cycloserine is an analog of the amino acid D-alanine.it Inhibits cell wall biosynthesis (D-Ala peptide bond formation) and Also prevents conversion of D-Ala to L-Ala.
Publictions citing BOC Sciences Products
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Purity:
>98%
Synonyms:
CI-879
MSDS:
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1.Effects of Low-Dose Amoxicillin on Staphylococcus aureus USA300 Biofilms.
Mlynek KD1, Callahan MT1, Shimkevitch AV1, Farmer JT1, Endres JL2, Marchand M1, Bayles KW2, Horswill AR3, Kaplan JB4. Antimicrob Agents Chemother. 2016 Feb 8. pii: AAC.02070-15. [Epub ahead of print]
Previous studies showed that sub-MIC levels of β-lactam antibiotics stimulate biofilm formation in most methicillin-resistant Staphylococcus aureus (MRSA) strains. Here we investigated this process by measuring the effects of sub-MIC amoxicillin on biofilm formation by the epidemic community-associated MRSA strain USA300. We found that sub-MIC amoxicillin increased the ability of USA300 cells to attach to surfaces and form biofilms under both static and flow conditions. We also found that USA300 biofilms cultured in sub-MIC amoxicillin were thicker, contained more pillar and channel structures, and were less porous than biofilms cultured without antibiotic. Biofilm formation in sub-MIC amoxicillin correlated with the production of extracellular DNA (eDNA). However, eDNA released by amoxicillin-induced cell lysis alone was evidently not sufficient to stimulate biofilm. Sub-MIC levels of two other cell wall-active agents with different mechanisms of action - D-cycloserine and fosfomycin - also stimulated eDNA-dependent biofilm, suggesting that biofilm formation may be a mechanistic adaptation to cell wall stress.
2.Xylopia aethiopica fruit extract exhibits antidepressant-like effect via interaction with serotonergic neurotransmission in mice.
Biney RP1, Benneh CK2, Ameyaw EO3, Boakye-Gyasi E2, Woode E2. J Ethnopharmacol. 2016 May 26;184:49-57. doi: 10.1016/j.jep.2016.02.023. Epub 2016 Feb 20.
ETHNOPHARMACOLOGICAL RELEVANCE: Xylopia aethiopica has been used traditionally to treat some central nervous system disorders including epilepsy.
3.The Emotional Brain as a Predictor and Amplifier of Chronic Pain.
Vachon-Presseau E1, Centeno MV1, Ren W1, Berger SE1, Tétreault P1, Ghantous M1, Baria A1, Farmer M1, Baliki MN1, Schnitzer TJ1, Apkarian AV2. J Dent Res. 2016 Mar 10. pii: 0022034516638027. [Epub ahead of print]
Human neuroimaging studies and complementary animal experiments now identify the gross elements of the brain involved in the chronification of pain. We briefly review these advances in relation to somatic and orofacial persistent pain conditions. First, we emphasize the importance of reverse translational research for understanding chronic pain-that is, the power of deriving hypotheses directly from human brain imaging of clinical conditions that can be invasively and mechanistically studied in animal models. We then review recent findings demonstrating the importance of the emotional brain (i.e., the corticolimbic system) in the modulation of acute pain and in the prediction and amplification of chronic pain, contrasting this evidence with recent findings regarding the role of central sensitization in pain chronification, especially for orofacial pain. We next elaborate on the corticolimbic circuitry and underlying mechanisms that determine the transition to chronic pain.
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CAS 68-41-7 D-Cycloserine

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