Flavor & Fragrance
Product Name:
(+)-Carvone, (S)-(+)-Carvone, (S)-(+)-p-Mentha-6,8-dien-2-one, 2-Cyclohexen-1-one, 2-methyl-5-(1-methylethenyl)-, (5S)-, 2-Cyclohexen-1-one, 2-methyl-5-(1-methylethenyl)-, (S)-, d-CARVONE (SYNTHETIC) FCC
CAS Number:
Molecular Weight:
Molecular Formula:
Olfactive Family:
Odor description:
Characteristic caraway (rye) odor.
Chemical Structure

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Reference Reading

1.Modulating effect of d-carvone on 1,2-dimethylhydrazine-induced pre-neoplastic lesions, oxidative stress and biotransforming enzymes, in an experimental model of rat colon carcinogenesis.
Vinothkumar R1, Sudha M, Viswanathan P, Kabalimoorthy J, Balasubramanian T, Nalini N. Cell Prolif. 2013 Dec;46(6):705-20. doi: 10.1111/cpr.12062. Epub 2013 Sep 30.
OBJECTIVES: The present study has aimed to evaluate chemopreventive potential of d-carvone on oxidative stress markers, biotransforming enzymes, incidence of colonic polyps and aberrant crypt foci (ACF) in 1,2-dimethylhydrazine (DMH)-induced experimental colon carcinogenesis.
2.Ethnobotanical survey of medicinal plants used in the Maseru district of Lesotho.
Seleteng Kose L1, Moteetee A2, Van Vuuren S3. J Ethnopharmacol. 2015 Jul 21;170:184-200. doi: 10.1016/j.jep.2015.04.047. Epub 2015 May 7.
ETHNOPHARMACOLOGICAL RELEVANCE: Ethnobotanical knowledge in Lesotho is passed on orally from one generation to another. As a result it has not been well documented. Existing publications have relied on previous literature and are limited either in terms of scope or coverage. Furthermore, some of them are out of print. Therefore, there are gaps in the documentation of medicinal plants used in Lesotho.
3.S-carvone suppresses cellulase-induced capsidiol production in Nicotiana tabacum by interfering with protein isoprenylation.
Huchelmann A1, Gastaldo C, Veinante M, Zeng Y, Heintz D, Tritsch D, Schaller H, Rohmer M, Bach TJ, Hemmerlin A. Plant Physiol. 2014 Feb;164(2):935-50. doi: 10.1104/pp.113.232546. Epub 2013 Dec 23.
S-Carvone has been described as a negative regulator of mevalonic acid (MVA) production by interfering with 3-hydroxy-3-methyl glutaryl coenzyme A reductase (HMGR) activity, a key player in isoprenoid biosynthesis. The impact of this monoterpene on the production of capsidiol in Nicotiana tabacum, an assumed MVA-derived sesquiterpenoid phytoalexin produced in response to elicitation by cellulase, was investigated. As expected, capsidiol production, as well as early stages of elicitation such as hydrogen peroxide production or stimulation of 5-epi-aristolochene synthase activity, were repressed. Despite the lack of capsidiol synthesis, apparent HMGR activity was boosted. Feeding experiments using (1-13C)Glc followed by analysis of labeling patterns by 13C-NMR, confirmed an MVA-dependent biosynthesis; however, treatments with fosmidomycin, an inhibitor of the MVA-independent 2-C-methyl-D-erythritol 4-phosphate (MEP) isoprenoid pathway, unexpectedly down-regulated the biosynthesis of this sesquiterpene as well.
4.Enantiospecific total synthesis of N-methylwelwitindolinone D isonitrile.
Styduhar ED1, Huters AD, Weires NA, Garg NK. Angew Chem Int Ed Engl. 2013 Nov 18;52(47):12422-5. doi: 10.1002/anie.201307464. Epub 2013 Oct 2.
The total synthesis of N-methylwelwitindolinone D isonitrile (1) has been achieved in 17 steps from a readily available carvone derivative. The route features a double C-H functionalization event involving a keto oxindole substrate to introduce the tetrahydrofuran ring of the natural product.