D-3263 - CAS 947257-66-1
Catalog number:
947257-66-1
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
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Description:
D-3263 is a TRPM8 agonist ( transient receptor potential melastatin member 8) with potential antineoplastic activity. The active ingredient in enteric-coated TRPM8 agonist D-3263 hydrochloride binds to and activates TRPM8, which may result in an increase in calcium and sodium entry; the disruption of calcium and sodium homeostasis; and the induction of cell death in TRPM8-expressing tumor cells. This agent may decrease dihydrotestosterone (DHT) levels, which may contribute to its inhibitory effects on prostate cancer and BPH. TRPM8 is a transmembrane calcium channel protein that is normally expressed in prostate cells and appears to be overexpressed in benign prostatic hyperplasia (BPH) and in prostate cancer.
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Synonyms:
D-3263; EC D-3263 HCl;
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Current Developer:
Dendreon (Seattle, WA, USA)
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CAS 947257-66-1 D-3263

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