Cytosporone B - CAS 321661-62-5
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Cytosporone B, also called as Csn-B or Dothiorelone G, is the first naturally nuclear orphan receptorNur77 agonist with an EC50 of 0.278 nM.
Publictions citing BOC Sciences Products
  • >> More
Brife Description:
A naturally occurring agonist for the nuclear receptor Nur77 (IC50 = 0.278 nM)
3,5-dihydroxy-2-(1-oxooctyl)-benzeneacetic acid, ethyl ester; Cytosporone B, Csn-B
DMSO: 10 mM
Store in a cool and dry place (or refer to the Certificate of Analysis).
Boiling Point:
471.6±24.0 ℃ at 760 Torr
1.126±0.06 g/cm3
Canonical SMILES:
1.Cytosporone B, an inhibitor of the type III secretion system of Salmonella enterica serovar Typhimurium.
Li J1, Lv C, Sun W, Li Z, Han X, Li Y, Shen Y. Antimicrob Agents Chemother. 2013 May;57(5):2191-8. doi: 10.1128/AAC.02421-12. Epub 2013 Mar 4.
Bacterial virulence factors have been increasingly regarded as attractive targets for development of novel antibacterial agents. Virulence inhibitors are less likely to generate bacterial resistance, which makes them superior to traditional antibiotics that target bacterial viability. Salmonella enterica serovar Typhimurium, an important food-borne human pathogen, has type III secretion system (T3SS) as its major virulence factor. T3SS secretes effector proteins to facilitate invasion into host cells. In this study, we identified several analogs of cytosporone B (Csn-B) that strongly block the secretion of Salmonella pathogenicity island 1 (SPI-1)-associated effector proteins, without affecting the secretion of flagellar protein FliC in vitro. Csn-B and two other derivatives exhibited a strong inhibitory effect on SPI-1-mediated invasion to HeLa cells, while no significant toxicity to bacteria was observed. Nucleoid proteins Hha and H-NS bind to the promoters of SPI-1 regulator genes hilD, hilC, and rtsA to repress their expression and consequently regulate the expression of SPI-1 apparatus and effector genes.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related ROR Products

CAS 293753-05-6 SR3335

(CAS: 293753-05-6)

The retinoic acid receptor-related receptors (RORs) are orphan nuclear receptors with diverse putative roles. SR 3335 is a selective inverse agonist of RORα, co...

CAS 1246525-60-9 SR1078

(CAS: 1246525-60-9)

SR 1078 is a selective agonist of RORα and RORγ that stimulates ROR transcriptional activity in HEK293 cell reporter assays.

CAS 321661-62-5 Cytosporone B

Cytosporone B
(CAS: 321661-62-5)

Cytosporone B, also called as Csn-B or Dothiorelone G, is the first naturally nuclear orphan receptorNur77 agonist with an EC50 of 0.278 nM.

CAS 2055536-64-4 LYC-55716

(CAS: 2055536-64-4)

LYC-55716 is a first-in-class oral, small-molecule agonist of nuclear receptor retinoic acid–related orphan receptor γ (RORγ).

(CAS: 1422171-08-1)

TMP778 is a selective RORγt inverse agonist. TMP778 can selectively block mouse Th17 cell differentiation in vitro and impair Th17 cell development in vivo upon...

ROR gamma-t-IN-1
(CAS: 1426802-50-7)

ROR gamma-t-IN-1, an orally bioavailable and CNS penetrant RORγt inhibitors. In vivo: it demonstrated EAE efficacy dose dependently via oral administration RORγ...

CAS 1335106-03-0 SR1001

(CAS: 1335106-03-0)

Retinoic-acid-receptor-related orphan receptors (ROR) α and γ play a key role in the development of T-helper cells that produce interleukin-17 (TH17 cells), a s...

ROR gama modulator 1
(CAS: 1474110-21-8)

ROR gama modulator 1, a tetrahydropyranylmethoxy benzenesulfonamide compound, is a retinoid-related orphan receptor gamma (RORy) modulator.

(CAS: 1677668-27-7)

GNE-6468, an imidazopyrimidine derivative, has been found to be a RORc inverse agonist that could be more effective than other members and be significant in stu...

Chemical Structure

CAS 321661-62-5 Cytosporone B

Quick Inquiry

Verification code

Featured Items