Cytosporone B - CAS 321661-62-5
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C18H26O5
Molecular Weight:
322.4
COA:
Inquire
Targets:
ROR
Description:
Cytosporone B, also called as Csn-B or Dothiorelone G, is the first naturally nuclear orphan receptorNur77 agonist with an EC50 of 0.278 nM.
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Brife Description:
A naturally occurring agonist for the nuclear receptor Nur77 (IC50 = 0.278 nM)
Synonyms:
3,5-dihydroxy-2-(1-oxooctyl)-benzeneacetic acid, ethyl ester; Cytosporone B, Csn-B
Solubility:
DMSO: 10 mM
Storage:
Store in a cool and dry place (or refer to the Certificate of Analysis).
MSDS:
Inquire
Boiling Point:
471.6±24.0 ℃ at 760 Torr
Density:
1.126±0.06 g/cm3
InChIKey:
UVVWQQKSNZLUQA-UHFFFAOYSA-N
InChI:
1S/C18H26O5/c1-3-5-6-7-8-9-15(20)18-13(11-17(22)23-4-2)10-14(19)12-16(18)21/h10,12,19,21H,3-9,11H2,1-2H3
Canonical SMILES:
OC1=CC(CC(OCC)=O)=C(C(CCCCCCC)=O)C(O)=C1
1.Cytosporone B, an inhibitor of the type III secretion system of Salmonella enterica serovar Typhimurium.
Li J1, Lv C, Sun W, Li Z, Han X, Li Y, Shen Y. Antimicrob Agents Chemother. 2013 May;57(5):2191-8. doi: 10.1128/AAC.02421-12. Epub 2013 Mar 4.
Bacterial virulence factors have been increasingly regarded as attractive targets for development of novel antibacterial agents. Virulence inhibitors are less likely to generate bacterial resistance, which makes them superior to traditional antibiotics that target bacterial viability. Salmonella enterica serovar Typhimurium, an important food-borne human pathogen, has type III secretion system (T3SS) as its major virulence factor. T3SS secretes effector proteins to facilitate invasion into host cells. In this study, we identified several analogs of cytosporone B (Csn-B) that strongly block the secretion of Salmonella pathogenicity island 1 (SPI-1)-associated effector proteins, without affecting the secretion of flagellar protein FliC in vitro. Csn-B and two other derivatives exhibited a strong inhibitory effect on SPI-1-mediated invasion to HeLa cells, while no significant toxicity to bacteria was observed. Nucleoid proteins Hha and H-NS bind to the promoters of SPI-1 regulator genes hilD, hilC, and rtsA to repress their expression and consequently regulate the expression of SPI-1 apparatus and effector genes.
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CAS 321661-62-5 Cytosporone B

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