Cytidine - CAS 65-46-3
Catalog number: 65-46-3
Category: Inhibitor
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Molecular Formula:
C9H13N3O5
Molecular Weight:
243.22
COA:
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Targets:
Nucleoside Antimetabolite/Analog
Description:
Cytidine is a nucleoside molecule that is formed when cytosine is attached to a ribose ring, cytidine is a component of RNA.
Purity:
>98%
Synonyms:
MK-0431; MK 0431; MK0431
MSDS:
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InChIKey:
UHDGCWIWMRVCDJ-XVFCMESISA-N
InChI:
InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7-,8-/m1/s1
Canonical SMILES:
C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O
1.Effect of salts on retention in hydrophilic interaction chromatography.
Alpert AJ J Chromatogr A. 2018 Feb 23;1538:45-53. doi: 10.1016/j.chroma.2018.01.038. Epub 2018 Jan 31.
There is a widespread belief that salts promote retention of solutes in hydrophilic interaction chromatography (HILIC) by expanding the volume of the immobilized layer of water on the surface of the stationary phase. To date, all studies of this premise have had flaws or limitations that left the question open. This study explored the effects of salt type and concentration. The effect of the anion was studied with four triethylammonium salts, ranging from the kosmotropic sulfate to the chaotropic perchlorate, at pH values of both 3 and 6. Concentrations ranged from 5-120 mM. All analytes were neutral except for cytosine and cytidine, which had (+) charge at pH 3. Sulfate markedly promoted retention of cytosine, cytidine and phloroglucinol. At high sulfate levels retention of cytosine and cytidine decreased again, presumably due to a "salting-out" effect. With perchlorate anion, retention of cytosine decreased steadily as salt concentration increased, while retention of other standards increased or was unchanged. The effect of the cation was examined by comparing the retention of a tryptic peptide containing either phosphoserine or aspartic acid at the same position. Salts of methylphosphonic acid were used at pH 2.
2.Unusual sensitivity of Escherichia coli to adenine or adenine plus histidine.
Mosteller RD;Goldstein RV J Bacteriol. 1975 Aug;123(2):750-1.
The W3110 strain of Escherichia coli K-12 is unusually sensitive to adenine. Inhibition of growth is relieved by a combination of thiamine and uridine (or cytidine). In the presence of histidine, inhibition is more severe and is relieved by a combination of thiamine, glycine, uridine (or cytidine), and inosine (or guanosine).
3.Inhibition of a yeast LTR retrotransposon by human APOBEC3 cytidine deaminases.
Dutko JA;Schäfer A;Kenny AE;Cullen BR;Curcio MJ Curr Biol. 2005 Apr 12;15(7):661-6.
The mammalian APOBEC3 family of cytidine deaminases includes several members that possess potent antiretroviral activity. Human APOBEC3F and APOBEC3G are specifically incorporated into human immunodeficiency virus type 1 (HIV-1) progeny virions in the absence of virion infectivity factor (Vif), where they deaminate deoxycytidine to deoxyuridine on the minus strand of nascent reverse transcripts. Editing of the HIV-1 cDNA leads to its degradation or to G to A hypermutation of the integrated provirus. Here, we show that APOBEC3 proteins also restrict the activity of a distantly related long terminal repeat (LTR) retrotransposon. When expressed in the yeast Saccharomyces cerevisiae, human APOBEC3C, APOBEC3F, or APOBEC3G or mouse APOBEC3 potently inhibit replication of the Ty1 LTR retrotransposon. APOBEC3G interacts with Ty1 Gag and is packaged into Ty1 virus-like particles (VLPs) by a mechanism that closely resembles the one it uses to enter HIV-1 virions. Expression of APOBEC3G results in a reduced level of Ty1 cDNA integration and G to A editing of integrated Ty1 cDNA. Our findings indicate that APOBEC3G restricts Ty1 and HIV-1 by similar mechanisms and suggest that the APOBEC3 proteins target a substantially broader spectrum of retroelements than previously appreciated.
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