Cyprodime hydrochloride - CAS 118111-54-9
Category: Inhibitor
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Molecular Formula:
C22H30NO3Cl
Molecular Weight:
391.93
COA:
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Targets:
Opioid Receptor
Description:
Cyprodime hydrochloride is a selective μ-opioid receptor antagonist from the morphinan family of drugs. Its Ki values are 5.4, 244.6 and 2187 nM for μ-, δ- and κ-opioid receptors respectively. It blocks the μ-opioid receptor without affecting the δ-opioid or κ-opioid receptors. It is useful for scientific research as it allows the μ-opioid receptor to be selectively deactivated so that the actions of the δ and κ receptors can be studied separately. It reduces levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson's disease.
Purity:
≥98% by HPLC
Synonyms:
17-(Cyclopropylmethyl)-4,14-dimethoxymorphinan-6-one hydrochloride
MSDS:
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InChIKey:
INUCRGMCKDQKNA-CEMLEFRQSA-N
InChI:
InChI=1S/C22H29NO3/c1-25-18-5-3-4-16-12-19-22(26-2)9-8-17(24)13-21(22,20(16)18)10-11-23(19)14-15-6-7-15/h3-5,15,19H,6-14H2,1-2H3/t19-,21-,22-/m1/s1
Canonical SMILES:
COC1=CC=CC2=C1C34CCN(C(C2)C3(CCC(=O)C4)OC)CC5CC5
1.Antinociceptive properties of the new alkaloid, cis-8, 10-di-N-propyllobelidiol hydrochloride dihydrate isolated from Siphocampylus verticillatus: evidence for the mechanism of action.
Santos AR1, Miguel OG, Yunes RA, Calixto JB. J Pharmacol Exp Ther. 1999 Apr;289(1):417-26.
The antinociceptive action of the alkaloid cis-8, 10-di-n-propyllobelidiol hydrochloride dehydrate (DPHD), isolated from Siphocampylus verticillatus, given i.p., p.o., i.t., or i.c.v., was assessed in chemical and thermal models of nociception in mice, such as acetic acid-induced abdominal constriction, formalin- and capsaicin-induced licking, and hot-plate and tail-flick tests. DPHD given by i.p., p.o., i.t., or i.c.v. elicited significant and dose-related antinociception. At the ID50 level, DPHD was about 2- to 39-fold more potent than aspirin and dipyrone, but it was about 14- to 119-fold less potent than morphine. Its analgesic action was reversed by treatment of animals with p-chlorophenylalanine, naloxone, cyprodime, naltrindole, nor-binaltrorphimine, L-arginine, or pertussis toxin. Its action was also modulated by adrenal-gland hormones but was not affected by gamma-aminobutyric acid type A or type B antagonist, bicuculine, or phaclofen, nor was it affected by glibenclamide.
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CAS 118111-54-9 Cyprodime hydrochloride

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