Cyclophosphamide - CAS 50-18-0
Catalog number:
50-18-0
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C7H15Cl2N2O2P
Molecular Weight:
261.09
COA:
Inquire
Targets:
Others (Nonspecific immune stimulation) | DNA Alkylator/Crosslinker
Description:
Low-dose preferentially deplets Treg cells; An alkylating agent of the nitrogen mustard type with antineoplastic and immunosuppressive activities; Phase I–II
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Brife Description:
Low-dose preferentially deplets Treg cells; An alkylating agent of the nitrogen mustard type with antineoplastic and immunosuppressive activities; Phase I–II
Appearance:
Fine White lyophilised solid
Synonyms:
Cytoxan; Clafen; Neosar; CTX; 2-Bis(2-chloroethyl)aminotetrahydro-2H-1,3,2-oxazophosphorine-2-oxide; N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide
Solubility:
In water, 1-5 g/100 mL at 23 °C; slightly soluble in benzene, carbon tetrachloride; very slightly soluble in ether and acetone.
Storage:
Stored at room temp or within 6 days if stored under refrigeration. When constituted with sterile water for injection or paraben-preserved bacteriostatic water for injection to a concn of 21 mg/ml, <1.5% cyclophosphamide decomposition will occur within 8
MSDS:
Inquire
Application:
Broad-spectrum antineoplastic agents. Cyclophosphamide can be used in the treatment of leukemia and other cancers.
Quality Standard:
In-house
Quantity:
Grams-Kilos
Boiling Point:
336
Melting Point:
41-45°C
InChIKey:
CMSMOCZEIVJLDB-UHFFFAOYSA-N
InChI:
InChI=1S/C7H15Cl2N2O2P/c8-2-5-11(6-3-9)14(12)10-4-1-7-13-14/h1-7H2,(H,10,12)
Canonical SMILES:
C1CNP(=O)(OC1)N(CCCl)CCCl
1.Control of nausea with palonosetron versus granisetron, both combined with dexamethasone, in patients receiving cisplatin- or anthracycline plus cyclophosphamide-based regimens.
Kubota K1, Saito M2, Aogi K3, Sekine I4, Yoshizawa H5, Yanagita Y6, Sakai H7, Inoue K8, Kitagawa C9, Ogura T10. Support Care Cancer. 2016 Apr 29. [Epub ahead of print]
PURPOSE: In a comparative phase 3 study involving 1114 Japanese patients receiving highly emetogenic chemotherapy (HEC), palonosetron (PALO) was found to be superior to granisetron (GRA) for the prophylaxis of chemotherapy-induced nausea and vomiting (CINV) in the delayed phase. This post hoc analysis of the phase 3 study evaluated the efficacy of PALO for the control of nausea.
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CAS 50-18-0 Cyclophosphamide

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