|Targets||Others (Nonspecific immune stimulation) | DNA Alkylator/Crosslinker|
|Description||Low-dose preferentially deplets Treg cells; An alkylating agent of the nitrogen mustard type with antineoplastic and immunosuppressive activities; Phase I–II|
|Brife Description||Low-dose preferentially deplets Treg cells; An alkylating agent of the nitrogen mustard type with antineoplastic and immunosuppressive activities; Phase I–II|
|Appearance||Fine White lyophilised solid|
|Synonyms||Cytoxan; Clafen; Neosar; CTX; 2-Bis(2-chloroethyl)aminotetrahydro-2H-1,3,2-oxazophosphorine-2-oxide; N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide|
|Solubility||In water, 1-5 g/100 mL at 23 °C; slightly soluble in benzene, carbon tetrachloride; very slightly soluble in ether and acetone.|
|Storage||Stored at room temp or within 6 days if stored under refrigeration. When constituted with sterile water for injection or paraben-preserved bacteriostatic water for injection to a concn of 21 mg/ml, <1.5% cyclophosphamide decomposition will occur within 8|
|Application||Broad-spectrum antineoplastic agents. Cyclophosphamide can be used in the treatment of leukemia and other cancers.|
Recombinant human IL‑2; Interleukin-2 is a secreted cytokine, also called IL-2. Aldesleukin (IL-2 made in the laboratory) is being used as a biological response...
Oxaliplatin is a platinum-based antineoplastic agent used in cancer chemotherapy that inhibits DNA synthesis by conforming DNA adducts in cancer cells.
Lomustine (420 μM) triggers apoptosis through the mitochondrial pathway via decrease in the level of the anti-apoptosis proteins Bcl-2 and Bcl-xl, respectively.
Busulfan is a cell cycle non-specific alkylating antineoplastic agent.
Treosulfan is the prodrug of a bifunctional sulfonate alkylating agent with myeloablative, immunosuppresive, and antineoplastic activities. Under physiological ...
SJG136 is a pyrrolobenzodiazepine dimer with potential antineoplastic activity. SJG-136 binds to the minor groove of DNA and induces interstrand cross-links bet...
Altretamine hydrochloride, also called as hexamethylmelamine hydrochloride, is an alkylating agent with apparently less toxicity compared to other cytotoxic dru...
Low-dose preferentially deplets Treg cells; An alkylating agent of the nitrogen mustard type with antineoplastic and immunosuppressive activities; Phase I–II
VAL-083 is a bi-functional alkylating agent; inhibit U251 and SF188 cell growth in monolayer better than TMZ and caused apoptosis.
Recombinant human IFNα; A type I interferon consisting of 165 amino acid residues with lysine in position 23. It is used extensively as an antiviral or antineop...
Fotemustine is a chloroethylating nitrosourea with antineoplastic activity. Fotemustine alkylates guanine by forming chloroethyl adducts at the 6 position of gu...
Cgp 6809 is a new methylnitrosoureido-sugar derivative. It is active against a broad spectrum of transplantable tumours in mice and rats. But Phase I clinical t...
Satraplatin, also known as JM216, is a platinum compound that is currently under investigation as one treatment of patients with advanced prostate cancer who ha...
Anti-CD25 (IL-2 receptor α‑chain) antibody; A humanized mAb of the human IgG1 isotype that binds specifically to the Tac epitope on the α-subunit (CD25) of the ...
Carboplatin is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism.
Cisplatin induces cytotoxic by interaction with DNA to form DNA adducts which activate several signal transduction pathways, including Erk, p53, p73, and MAPK, ...
Carmustine is antineoplastic nitrosourea. Carmustine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA fun...
Temozolomide is an oral chemotherapy drug.The therapeutic benefit of temozolomide depends on its ability to alkylate/methylate DNA, which most often occurs at t...