Cyclopenta[c]pyran-4-carboxylicacid, 1-(b-D-glucopyranosyloxy)-1,4a,5,7a-tetrahydro-5-hydroxy-7-(hydroxymethyl)-,(1S,4aS,5S,7aS)- - CAS 14259-55-3
Catalog number: 14259-55-3
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Molecular Formula:
C16H22O11
COA:
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Chemical Family:
Iridoids
Description:
Deacetylasperulosidic acid inhibited the reduction of ear swelling, and also cancelled the suppression of IL-2 production along with the activation of natural killer cells in the same manner as that of Noni-ext.
Purity:
>98%
Appearance:
Powder
Synonyms:
Cyclopenta[c]pyran-4-carboxylicacid, 1-(b-D-glucopyranosyloxy)-1,4a,5,7a-tetrahydro-5-hydroxy-7-(hydroxymethyl)-,(1S,4aS,5S,7aS)-
MSDS:
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Quality Standard:
Enterprise Standard
Quantity:
Milligrams-Grams
1.[Iridoids of Borreria verticillata].
Sainty D;Bailleul F;Delaveau P;Jacquemin H Planta Med. 1981 Jul;42(7):260-4.
Seven iridoids are isolated from Borreria verticillata root barks: daphylloside 1, asperuloside 2, feretoside 3, methyl desacetylasperulosidate 4, desacetylasperuloside 5, asperulosidic acid 6 and desacetylasperulosidic acid 7. Their structures result from spectroscopic analysis and are proved by chemical correlation.
2.Three new iridoid glucoside salts from Hedyotis tenelliflora Growing in Vietnam.
Van Long LH;Nga VT;Dam NP;Hung MA;Dung TD;Quang TT;Phung NK Nat Prod Commun. 2013 Nov;8(11):1507-8.
Three new sodium salts of iridoid acids, deacetylasperulosidic acid sodium salt (1), teneoside D (2), and teneoside E (3) were isolated from the leaves of Hedyotis tenelliflora Blume (Rubiaceae), together with seven known iridoids, 6alpha-hydroxygeniposide (4), 6beta-hydroxygeniposide (5), 6-O-methyldeacetylasperulosidic acid methyl ester (6), 6-O-methylscandoside methyl ester (7), 6alpha-methoxygeniposidic acid (8), daphylloside (9), and mollugoside methyl ester (10). Their chemical structures were elucidated by 1D and 2D NMR spectroscopy, as well as HR-ESI-MS analysis.
3.Antiglycation Activity of Iridoids and Their Food Sources.
West BJ;Uwaya A;Isami F;Deng S;Nakajima S;Jensen CJ Int J Food Sci. 2014;2014:276950. doi: 10.1155/2014/276950. Epub 2014 Dec 29.
Iridoids are dietary phytochemicals that may have the ability to inhibit the formation of advanced glycation end products (AGEs). Three studies were conducted to investigate this anti-AGE potential. First, the inhibition of fluorescence intensity by food-derived iridoids, after 4 days of incubation with bovine serum albumin, glucose, and fructose, was used to evaluate in vitro antiglycation activity. Next, an 8-week open-label pilot study used the AGE Reader to measure changes in the skin autofluorescence of 34 overweight adults who consumed daily a beverage containing food sources of iridoids. Finally, a cross-sectional population study with 3913 people analyzed the relationship between daily iridoid intake and AGE accumulation, as measured by skin autofluorescence with the TruAge scanner. In the in vitro test, deacetylasperulosidic acid and loganic acid both inhibited glycation in a concentration-dependent manner, with respective IC50 values of 3.55 and 2.69 mM. In the pilot study, average skin autofluorescence measurements decreased by 0.12 units (P < 0.05). The cross-sectional population survey revealed that, for every mg of iridoids consumed, there is a corresponding decline in AGE associated age of 0.
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Chemical Structure

CAS 14259-55-3 Cyclopenta[c]pyran-4-carboxylicacid, 1-(b-D-glucopyranosyloxy)-1,4a,5,7a-tetrahydro-5-hydroxy-7-(hydroxymethyl)-,(1S,4aS,5S,7aS)-

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