Cyclocytidine HCl - CAS 10212-25-6
Catalog number: 10212-25-6
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C9H12ClN3O4
Molecular Weight:
261.66
COA:
Inquire
Targets:
Others
Description:
Cyclocytidine is the prodrug of cytarabine, which is a pyrimidine nucleoside analog that inhibits the DNA synthesis and used mainly in the treatment of leukemia.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
Synonyms:
NSC 145668 HCl
MSDS:
Inquire
1.Comparison of some biochemical parameters of arabinosylcytosine and cyclocytidine in L1210 murine leukemia cells.
Novotný L1, Reichelová V, Balázová E, Ujházy V. Neoplasma. 1990;37(1):13-22.
The basic biochemical characteristics of cyclocytidine hydrochloride (cC.HCl) and arabinosylcytosine (araC) were compared. It was demonstrated that despite different lipophilicity and different pK (4.15 for araC and 6.60 for cC.HCl), the mechanism of inhibition of DNA synthesis by both compounds is the same (ID50 for araC was 0.048 mumol/l and for cC. HCl 0.23 mumol/l). The compounds had a different mechanism of inhibition of RNA synthesis (ID50 for araC was 2.69 mmol/l and for cC.HCl 1.08 mmol/l) and showed a marginal effect on protein synthesis. Hydrolysis of the 0(2),2'-anhydro bond in cC.HCl and formation of araC in vivo was characterized by a Km = 280 mumol/l using HPLC. Deamination of araC in vivo was studied in healthy mice (Km = 247 mumol/l), 8.6% of arabinosyluracil 15 minutes after araC administration) and in mice with sensitive and araC resistant leukemia L1210 (15.5% and 8.5% of arabinosyluracil 15 minutes after araC administration, respectively).
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products


CC-17369
(CAS: 1547162-46-8)

CC-17369, a hydroxyisoindole derivative, is a metabolites of pomalidomide and has potential activity in anticancer study like multiple myeloma.

CAS 525-79-1 Kinetin

Kinetin
(CAS: 525-79-1)

Kinetin is a type of cytokinin, a class of plant hormone that promotes cell division.

CAS 93-14-1 Guaifenesin

Guaifenesin
(CAS: 93-14-1)

Guaifenesin is thought to act as an expectorant.

CAS 479-92-5 Isopropylantipyrinum

Isopropylantipyrinum
(CAS: 479-92-5)

Isopropylantipyrinum is a derivative of phenazone with similar analgesic and antipyretic effects.

Monohydroxy Netupitant
(CAS: 910808-12-7)

Monohydroxy Netupitant is the metabolite of Netupitant which is a potent and selective neurokinin-1 receptor (NK1) receptor antagonist. It is achiral and orally...

CAS 176957-55-4 CCT007093

CCT007093
(CAS: 176957-55-4)

CCT007093 is a potent PPM1D inhibitor or WIP1 inhibitor that selectively reduces viability of human tumour cell lines

CAS 75706-12-6 Leflunomide

Leflunomide
(CAS: 75706-12-6)

Leflunomideinhibits the reproduction of rapidly dividing cells by inhbiting the mitochondrial enzyme dihydroorotate dehydrogenase (DHODH).

CAS 1093069-32-9 JNJ-39327041

JNJ-39327041
(CAS: 1093069-32-9)

JNJ-39327041 is a bio-active chemical compound.

CAS 144675-97-8 Pixantrone Maleate

Pixantrone Maleate
(CAS: 144675-97-8)

Pixantrone is a synthetic, noncardiotoxic aza-anthracenedione analogue with potential antineoplastic activity. Pixantrone intercalates into DNA and induces topo...

CAS 52949-83-4 Ajugol

Ajugol
(CAS: 52949-83-4)

Ajugol is an iridiod glucoside isolated from the roots of Rehmannia glutinosa.

CAS 1629908-92-4 NSC 756093

NSC 756093
(CAS: 1629908-92-4)

NSC 756093 is the first inhibitor of GBP1 and PIM1 interaction with activity in paclitaxel resistant cells.

CAS 478336-92-4 ISO-1

ISO-1
(CAS: 478336-92-4)

ISO-1 is an inhibitor of the dopachrome tautomerase activity of MIF. It blocks the activation of NF-κB and TNF-α secretion from LPS-treated macrophages and impr...

GYKI-23107 dihydrochloride
(CAS: 83843-39-4)

GYKI-23107 is an antiarrhythmic agent with local anaesthetic activity.

SPDB
(CAS: 115088-06-7)

SPDB, a pyridyldithioyl compound, has been found to link to DM4 conjugates and probably influence the releasement of cytotoxic metabolitesin.

CAS 5072-26-4 Buthionine Sulphoximine

Buthionine Sulphoximine
(CAS: 5072-26-4)

Buthionine Sulphoximine, also known as NSC-326231, is a potent and specific inhibitor of alpha-glutamyl cysteine synthetase.

CAS 55285-14-8 Carbosulfan

Carbosulfan
(CAS: 55285-14-8)

Carbosulfan is an organic compound adherent as a insecticide.

CAS 66108-95-0 Iohexol

Iohexol
(CAS: 66108-95-0)

Iohexol is a low-osmolality contrast agent, sold under the trade name Omnipaque. Omnipaque 350 is commonly used as a contrast agent during coronary angiography.

EL-102
(CAS: 1233948-61-2)

EL102, a HIF1α inhibitor, has been found to have potential effect in restraining polymerisation of tubulin and influencing the stability of microtubule. IC50: 2...

CAS 113240-27-0 Cgp 29030A

Cgp 29030A
(CAS: 113240-27-0)

This molecular is a piperazine derivative and its Pharmacological activity probablely is inhibition on nociceptive dorsal horn neurons that processed input from...

MK-142 dimethanesulfonate
(CAS: 42794-63-8)

MK-142 is a bioactive agent with antiarrhythmic properties with its content in the skeletal muscles indicates a high affinity of the examined substance to the ...

Chemical Structure

CAS 10212-25-6 Cyclocytidine HCl

Quick Inquiry

Verification code

Featured Items