Cycloastragenol - CAS 84605-18-5
Catalog number:
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Cycloastragenol is a natural tetracyclic triterpenoid. It is an aglycone derivative of astragaloside IV found in the root of Korean Astragalus membranaceus. It has antiaging properties. lt may activate telomerase and stimulates telomerase activity and cell proliferation in human neonatal keratinocytes. It promotes scratch wound closure of human neonatal keratinocyte monolayers in vitro. lt obviously activated CYP2E1, and remarkably inhibited CYP3A4. lt is used as a nutraceutical. It stimulates the repair of DNA damage by activating telomerase,a nucleoprotein enzyme which catalyses synthesis and growth of telomeric DNA.
Publictions citing BOC Sciences Products
  • >> More
White Solid
10 mM in DMSO
-20°C Freezer
Cycloastragenol has antiaging properties. lt may activate telomerase and stimulates telomerase activity and cell proliferation in human neonatal keratinocytes. lt is used as a nutraceutical. It stimulates the repair of DNA damage by activating telomerase,a nucleoprotein enzyme.
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Boiling Point:
617.2±55.0 °C | Condition: Press: 760 Torr
Melting Point:
>230°C (dec.)
1.20±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
Canonical SMILES:
1.Smith degradation, an efficient method for the preparation of cycloastragenol from astragaloside IV.
Feng LM1, Lin XH1, Huang FX1, Cao J1, Qiao X1, Guo DA1, Ye M2. Fitoterapia. 2014 Jun;95:42-50. doi: 10.1016/j.fitote.2014.02.014. Epub 2014 Mar 5.
Cycloastragenol (CA) is the genuine sapogenin of astragaloside IV (ASI). This study focuses on the preparation of CA from ASI. Five hydrolysis methods were compared including H2SO4 hydrolysis, HCl hydrolysis, two-phase acid hydrolysis, mild acid hydrolysis, and Smith degradation. Seven hydrolysis products were purified, and five of them were identified as new compounds. The results indicated that Smith degradation was the most effective approach to prepare CA. In contrast, mild acid hydrolysis produced CA at a low yield, accompanied with the artificial sapogenin astragenol. The other three acid hydrolysis methods mainly produced astragenol. Furthermore, the reaction conditions for Smith degradation were optimized as follows: ASI was dissolved in 60% MeOH-H2O solution, oxidized with 5 equiv. NaIO4 for 12h, followed by reduction with 3 equiv. NaBH4 for 4h, and finally acidified with 1M H2SO4 at pH2 for 24h. Under the optimal conditions, CA could be prepared from ASI at a yield of 84.
2.Evaluation of a novel anti-aging topical formulation containing cycloastragenol, growth factors, peptides, and antioxidants.
Weiss RA, Weiss MA. J Drugs Dermatol. 2014 Sep;13(9):1135-9.
BACKGROUND/OBJECTIVE: This study investigates the efficacy, tolerance, and usability of a single product containing cycloastragenol, growth factors, peptides, and antioxidants to decrease the visible signs of aging, including fine lines, and wrinkles, texture, pore size, elasticity, skin color/clarity, redness, hydration, and overall skin quality.
3.Astragaloside IV and cycloastragenol are equally effective in inhibition of endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation in the endothelium.
Zhao Y1, Li Q2, Zhao W1, Li J3, Sun Y3, Liu K3, Liu B3, Zhang N4. J Ethnopharmacol. 2015 Jul 1;169:210-8. doi: 10.1016/j.jep.2015.04.030. Epub 2015 Apr 25.
ETHNOPHARMACOLOGICAL RELEVANCE: Astragaloside IV and cycloastragenol are present together in Astragalus membranaceus Moench (Fabaceae) and this study aims to simultaneously investigate their regulation of endothelial homeostasis in the setting of endoplasmic reticulum stress (ER stress).
4.Cycloastragenol is a potent telomerase activator in neuronal cells: implications for depression management.
Ip FC1, Ng YP, An HJ, Dai Y, Pang HH, Hu YQ, Chin AC, Harley CB, Wong YH, Ip NY. Neurosignals. 2014;22(1):52-63. doi: 10.1159/000365290. Epub 2014 Jul 31.
Cycloastragenol (CAG) is an aglycone of astragaloside IV. It was first identified when screening Astragalus membranaceus extracts for active ingredients with antiaging properties. The present study demonstrates that CAG stimulates telomerase activity and cell proliferation in human neonatal keratinocytes. In particular, CAG promotes scratch wound closure of human neonatal keratinocyte monolayers in vitro. The distinct telomerase-activating property of CAG prompted evaluation of its potential application in the treatment of neurological disorders. Accordingly, CAG induced telomerase activity and cAMP response element binding (CREB) activation in PC12 cells and primary neurons. Blockade of CREB expression in neuronal cells by RNA interference reduced basal telomerase activity, and CAG was no longer efficacious in increasing telomerase activity. CAG treatment not only induced the expression of bcl2, a CREB-regulated gene, but also the expression of telomerase reverse transcriptase in primary cortical neurons.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products

(CAS: 400044-47-5)

UK‑396082 is an activated thrombin activatable fibrinolysis inhibitor(Ki = 10 nM), exhibited antithrombotic efficacy in a rabbit model of venous thrombosis, yet...

CAS 154-23-4 Catechin

(CAS: 154-23-4)

(+)-Catechin is a flavonoid found primarily in higher woody plants as (+)-Catechin along with (-)-Epicatechin (cis form). Antidiarrheal.

(CAS: 1095181-60-4)

BMS779333 is a novel AR pan-antagonist with significantly improved cardiovascular and metabolic profiles. It has anti- tumor effect.

CAS 110267-81-7 Amrubicin

(CAS: 110267-81-7)

Amrubicin is a novel anthracycline derivative for treatment of bladder carcinoma.

(CAS: 1262414-04-9)

Cenerimod is an active Lysosphingolipid receptor agonist originated by Actelion Pharmaceuticals and EC50 value is 2.7 nM. It is a S1P1/EDG1 receptor agonist and...

CAS 71720-56-4 Fenoprofen calcium hydrate

Fenoprofen calcium hydrate
(CAS: 71720-56-4)

Fenoprofen calcium hydrate is a non-steroidal anti-inflammatory drug (NSAID).

GSK-2262167 sodium
(CAS: 1165923-54-5)

This molecular is a potent S1P3-sparing and S1P1 agonist. Meanwhile GSK-2262167 has a potent activity is in a collagen-induced arthritis model as efficacious as...

(CAS: 1337883-32-5)

DiZPK, a photocrosslinking amino acid, could be significant in revealling the physiological and functions of some proteins acting as a genetically encoded.

CAS 13860-66-7 N3PT

(CAS: 13860-66-7)

N3PT inhibits transketolase activity in a cell based assay. Competitive inhibition of TK by N3PT in cells treated with increasing doses of thiamine, expressed a...

CAS 50-35-1 Thalidomide

(CAS: 50-35-1)

Thalidomide was introduced as a sedative drug, immunomodulatory agent and also is investigated for treating symptoms of many cancers. Thalidomide inhibits an E3...

CAS 1084-65-7 Meticrane

(CAS: 1084-65-7)

Meticrane, a sulphonamide derivative, is an effective diuretic and also an inhibitor of peripheral-type benzodiazepine receptor. IC50: 1 μM.

CAS 517-28-2 Hematoxylin

(CAS: 517-28-2)

Hematoxylin (Hydroxybrazilin) is a compound that forms strongly colored complexes with certain metal ions, notably Fe(III) and Al(III) salts and a kind of stain...

CAS 552-94-3 Sasapyrine

(CAS: 552-94-3)

Sasapyrine (salsalate) is a nonsteroidal oral anti-inflammatory agent.Relative to other NSAIDs, salsalate has a weak inhibitory effect on the cyclooxygenase enz...

CAS 6859-01-4 Isorhynchophylline

(CAS: 6859-01-4)

Rhynchophylline and isorhynchophylline act as noncompetitive antagonists of the NMDA receptor and that this property may contribute to the neuroprotective and a...

CAS 137-66-6 L-Ascorbyl 6-palmitate

L-Ascorbyl 6-palmitate
(CAS: 137-66-6)

Ascorbyl palmitate is an ester formed from ascorbic acid and palmitic acid creating a fat-soluble form of vitamin C.

CAS 6747-15-5 D,L-3-Indolylglycine

(CAS: 6747-15-5)

D, L-3-Indolylglycine, similar to Tryptophan, is an unnatural amino acid.

CAS 867257-26-9 Tecarfarin

(CAS: 867257-26-9)

Tecarfarin is a vitamin K epoxide reductase inhibitor. It can attenuate venous and arterial thrombus formation in animal models by reducing the levels of the vi...

CAS 24316-19-6 Cephalotaxlen

(CAS: 24316-19-6)

Antiviral and antitumor agent.

(CAS: 850807-63-5)

RSM-932A is a novel anticancer drug. Its target is the human choline kinase alpha. Choline kinase alpha is an enzyme involved in increased lipid metabolism of c...

CAS 557-08-4 Zinc undecylenate

Zinc undecylenate
(CAS: 557-08-4)

Zinc undecylenate is a ungistatic fatty acid used in creams against fungal infections, eczemas, ringworm, and other cutaneous conditions.

Chemical Structure

CAS 84605-18-5 Cycloastragenol

Quick Inquiry

Verification code

Featured Items