CX546 - CAS 215923-54-9
Catalog number: 215923-54-9
Category: Inhibitor
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It is one of a series of AMPA modulators for the potential treatment of Alzheimer's disease, schizophrenia, and mild cognitive impairment (MCI). An ampakine drug that facilitates activation of glutamatergic AMPA receptors.
(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-piperidinylmethanone; 1-[(2,3-Dihydro-1,4-benzodioxin-6-yl)carbonyl]piperidine; CX546; CX 546; CX-546; UNII-PV6YEC8983; GR 87; GR-87; BDP 17; GR87; BDP17; BDP-17.
Canonical SMILES:
1.Ampakine CX546 increases proliferation and neuronal differentiation in subventricular zone stem/progenitor cell cultures.
Schitine C1, Xapelli S, Agasse F, Sardà-Arroyo L, Silva AP, De Melo Reis RA, de Mello FG, Malva JO. Eur J Neurosci. 2012 Jun;35(11):1672-83. doi: 10.1111/j.1460-9568.2012.08072.x. Epub 2012 Apr 16.
Ampakines are chemical compounds known to modulate the properties of ionotropic α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA)-subtype glutamate receptors. The functional effects attributed to ampakines involve plasticity and the increase in synaptic efficiency of neuronal circuits, a process that may be intimately associated with differentiation of newborn neurons. The subventricular zone (SVZ) is the main neurogenic niche of the brain, containing neural stem cells with brain repair potential. Accordingly, the identification of new pharmaceutical compounds with neurogenesis-enhancing properties is important as a tool to promote neuronal replacement based on the use of SVZ cells. The purpose of the present paper is to examine the possible proneurogenic effects of ampakine CX546 in cell cultures derived from the SVZ of early postnatal mice. We observed that CX546 (50 μm) treatment triggered an increase in proliferation, evaluated by BrdU incorporation assay, in the neuroblast lineage.
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CAS 215923-54-9 CX546

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