CX546 - CAS 215923-54-9
Catalog number: 215923-54-9
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C14H17NO3
Molecular Weight:
247.29
COA:
Inquire
Targets:
AMPAR
Description:
It is one of a series of AMPA modulators for the potential treatment of Alzheimer's disease, schizophrenia, and mild cognitive impairment (MCI). An ampakine drug that facilitates activation of glutamatergic AMPA receptors.
Purity:
>98%
Synonyms:
(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-piperidinylmethanone; 1-[(2,3-Dihydro-1,4-benzodioxin-6-yl)carbonyl]piperidine; CX546; CX 546; CX-546; UNII-PV6YEC8983; GR 87; GR-87; BDP 17; GR87; BDP17; BDP-17.
MSDS:
Inquire
InChIKey:
LJUNPHMOGNFFOS-UHFFFAOYSA-N
InChI:
InChI=1S/C14H17NO3/c16-14(15-6-2-1-3-7-15)11-4-5-12-13(10-11)18-9-8-17-12/h4-5,10H,1-3,6-9H2
Canonical SMILES:
C1CCN(CC1)C(=O)C2=CC3=C(C=C2)OCCO3
1.Ampakine CX546 increases proliferation and neuronal differentiation in subventricular zone stem/progenitor cell cultures.
Schitine C1, Xapelli S, Agasse F, Sardà-Arroyo L, Silva AP, De Melo Reis RA, de Mello FG, Malva JO. Eur J Neurosci. 2012 Jun;35(11):1672-83. doi: 10.1111/j.1460-9568.2012.08072.x. Epub 2012 Apr 16.
Ampakines are chemical compounds known to modulate the properties of ionotropic α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA)-subtype glutamate receptors. The functional effects attributed to ampakines involve plasticity and the increase in synaptic efficiency of neuronal circuits, a process that may be intimately associated with differentiation of newborn neurons. The subventricular zone (SVZ) is the main neurogenic niche of the brain, containing neural stem cells with brain repair potential. Accordingly, the identification of new pharmaceutical compounds with neurogenesis-enhancing properties is important as a tool to promote neuronal replacement based on the use of SVZ cells. The purpose of the present paper is to examine the possible proneurogenic effects of ampakine CX546 in cell cultures derived from the SVZ of early postnatal mice. We observed that CX546 (50 μm) treatment triggered an increase in proliferation, evaluated by BrdU incorporation assay, in the neuroblast lineage.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related AMPAR Products


CAS 201730-10-1 (R)-3,4-DCPG

(R)-3,4-DCPG
(CAS: 201730-10-1)

(R)-3,4-DCPG is an AMPA receptor antagonist with weak activity at NMDA receptors and no activity at kainate receptors.

CAS 375345-95-2 LY451395

LY451395
(CAS: 375345-95-2)

Incubation of LY451395 with Actinoplanes missouriensis NRRL B3342 generated several metabolites that were previously detected in the in vivo metabolism studies ...

CAS 2036081-86-2 JNJ 55511118

JNJ 55511118
(CAS: 2036081-86-2)

JNJ 55511118 has been found to be an AMPA receptor modulator and could probably be used as an anticonvulsant.

CAS 173952-44-8 SYM 2206

SYM 2206
(CAS: 173952-44-8)

SYM 2206 is a potent and noncompetitive AMPA receptor antagonist (IC50 = 2.8 μM ) that exhibits anticonvulsant activity in vivo. SYM 2206 acts allosterically at...

CAS 118876-58-7 NBQX

NBQX
(CAS: 118876-58-7)

This active molecular is an AMPA receptor antagonist which blocks AMPA receptors in 10-20µM concentrations. It is also a Glutamate receptor antagonist. NBQX was...

CAS 1026791-61-6 Org-26576

Org-26576
(CAS: 1026791-61-6)

Org-26576 is a positive allosteric modulator of AMPA receptor. Org-26576 increases the anteroventral and laterodorsal thalamus, cingulate cortex, dentate gyrus ...

CAS 1219633-99-4 PF 4778574

PF 4778574
(CAS: 1219633-99-4)

PF 4778574 is a potent brain penetrant AMPA receptor positive allosteric modulator (PAM) (Ki = 85 nM) that has been shown to enhance cognition in animal models.

CAS 178616-26-7 CFM-2

CFM-2
(CAS: 178616-26-7)

Potent and selective AMPA antagonist.

Chemical Structure

CAS 215923-54-9 CX546

Quick Inquiry

Verification code

Featured Items