|Description||It is one of a series of AMPA modulators for the potential treatment of Alzheimer's disease, schizophrenia, and mild cognitive impairment (MCI). An ampakine drug that facilitates activation of glutamatergic AMPA receptors.|
|Synonyms||(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-piperidinylmethanone; 1-[(2,3-Dihydro-1,4-benzodioxin-6-yl)carbonyl]piperidine; CX546; CX 546; CX-546; UNII-PV6YEC8983; GR 87; GR-87; BDP 17; GR87; BDP17; BDP-17.|
(R)-3,4-DCPG is an AMPA receptor antagonist with weak activity at NMDA receptors and no activity at kainate receptors.
Incubation of LY451395 with Actinoplanes missouriensis NRRL B3342 generated several metabolites that were previously detected in the in vivo metabolism studies ...
JNJ 55511118 has been found to be an AMPA receptor modulator and could probably be used as an anticonvulsant.
SYM 2206 is a potent and noncompetitive AMPA receptor antagonist (IC50 = 2.8 μM ) that exhibits anticonvulsant activity in vivo. SYM 2206 acts allosterically at...
This active molecular is an AMPA receptor antagonist which blocks AMPA receptors in 10-20µM concentrations. It is also a Glutamate receptor antagonist. NBQX was...
Org-26576 is a positive allosteric modulator of AMPA receptor. Org-26576 increases the anteroventral and laterodorsal thalamus, cingulate cortex, dentate gyrus ...
PF 4778574 is a potent brain penetrant AMPA receptor positive allosteric modulator (PAM) (Ki = 85 nM) that has been shown to enhance cognition in animal models.
Potent and selective AMPA antagonist.