|Related CAS||1353858-99-7 (CX-6258 HCl salt, hydrate)|
|Appearance||orange solid powder|
|Synonyms||(E)-5-chloro-3-((5-(3-(4-methyl-1,4-diazepane-1-carbonyl)phenyl)furan-2-yl)methylene)indolin-2-one; CX6258; CX-6258; CX 6258|
PIM inhibitor 1 phosphate
PAK4-IN-1 is an inhibitor of Pim (IC50< 35 nM).
AZD1208 is orally available, small molecule inhibitor of PIM kinases with potential antineoplastic activity. AZD1208 inhibits the activities of PIM1, PIM2 and P...
This active molecular is a potent PIM 1, 2, and 3 kinase inhibitor under the development of Novartis. In vivo, PIM447 reduces the tumor burden and also prevente...
Tp3654 is an inhibitor of Pim-1 and Pim-3 that has the potential to treat prostate cancer, acute myeloid leukemia, multiple sclerosis and psoriasis.
LKB1/AAK1 dual inhibitor
LKB1/AAK1 dual inhibitor is an effective inhitor against multi-kinase especially Pim-1 kinase, which has been newly found to highly expressed in sorts of isolat...
M-110, a PIM kinases inhibitor, has been found to restrain the proliferation of prostate cancer cell lines and also influence the signaling of Wnt/β-catenin. IC...
This active molecular is a selective ATP-competitive inhibitor of Pan-PIM kinase. LGB-321 is active in PIM2 dependent cell lines that is quite different to othe...
SMI-4a, also called as TCS-PIM-1-4a, a thiazolidinedione compound, is a potent, selective ATP-competitive inhibitor against Pim protein kinase (IC50 = 24 nM aga...
SGI-1776 is a small-molecule pan-Pim protein kinase inhibitor with potential antineoplastic activity. Pim kinase inhibitor SGI-1776 binds to and inhibits the ac...
CX-6258 hydrochloride hydrate
The hydrochloride hydrate salt form of CX-6258, a pan-Pim kinases inhibitor, has been found to have strong antiproliferative potencies against human solid tumor...
SMI-16a, a cell-permeable thiazolidinedione compound, is a selective and ATP-competitive Pim kinase inhibitor with IC50 values of 0.15, 0.02 and 48 μM for Pim1,...
TCS PIM-1 1
GDC-0339, also called as SCHEMBL14801965, is a selective inhibitor of BaF3 PIM1 that has the potential for treatment of cancer. BaF3 PIM1: IC50= 43.6 nM; PIM1 L...