|Description||CVT10216 is a potent and selective, reversible inhibitor of aldehyde dehydrogenase 2 (ALDH2) with IC50 value of 29nM, thereby inhibiting dopamine synthesis. It is active in suppressing alcohol and cocaine use, and anxiety. It has been shown to produce anxiolytic effects in four different rodent models, including a model of repeated alcohol withdrawal-induced anxiety. It increases acetaldehyde after alcohol gavage and inhibits 2-bottle choice alcohol intake in heavy drinking rodents. It prevents operant self-administration and eliminates cue-induced reinstatement of alcohol seeking. It also prevents alcohol-induced increases in NAc DA without changing basal levels.|
|Appearance||White to beige powder|
|Synonyms||CVT-10216;3-[[[3-[4-[(Methylsulfonyl)amino]phenyl]-4-oxo-4H-chromen-7-yl]oxy]methyl]benzoic acid;GS 455534|
|Solubility||DMSO: soluble10 mg/mL, clear|
|Application||CVT10216 is active in suppressing alcohol and cocaine use, and anxiety.|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
|Quantity||Grams to Kilograms|
|Melting Point||714.2±70.0 °C | Condition: Press: 760 Torr|
|Density||1.468±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr|
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