CVT10216 - CAS 1005334-57-5
Catalog number:
1005334-57-5
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C24H19NO7S
Molecular Weight:
465.48
COA:
Inquire
Targets:
Others
Description:
CVT10216 is a potent and selective, reversible inhibitor of aldehyde dehydrogenase 2 (ALDH2) with IC50 value of 29nM, thereby inhibiting dopamine synthesis. It is active in suppressing alcohol and cocaine use, and anxiety. It has been shown to produce anxiolytic effects in four different rodent models, including a model of repeated alcohol withdrawal-induced anxiety. It increases acetaldehyde after alcohol gavage and inhibits 2-bottle choice alcohol intake in heavy drinking rodents. It prevents operant self-administration and eliminates cue-induced reinstatement of alcohol seeking. It also prevents alcohol-induced increases in NAc DA without changing basal levels.
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Purity:
>98 %
Appearance:
White to beige powder
Synonyms:
CVT-10216;3-[[[3-[4-[(Methylsulfonyl)amino]phenyl]-4-oxo-4H-chromen-7-yl]oxy]methyl]benzoic acid;GS 455534
Solubility:
DMSO: soluble10 mg/mL, clear
Storage:
2-8ºC
MSDS:
Inquire
Application:
CVT10216 is active in suppressing alcohol and cocaine use, and anxiety.
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Grams to Kilograms
Melting Point:
714.2±70.0 °C | Condition: Press: 760 Torr
Density:
1.468±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
InChIKey:
YYOOFJZTRCPVFD-UHFFFAOYSA-N
InChI:
InChI=1S/C24H19NO7S/c1-33(29,30)25-18-7-5-16(6-8-18)21-14-32-22-12-19(9-10-20(22)23(21)26)31-13-15-3-2-4-17(11-15)24(27)28/h2-12,14,25H,13H2,1H3,(H,27,28)
Canonical SMILES:
CS(=O)(=O)NC1=CC=C(C=C1)C2=COC3=C(C2=O)C=CC(=C3)OCC4=CC=CC(=C4)C(=O)O
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