Cutamesine - CAS 165377-43-5
Catalog number: 165377-43-5
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Sigma Receptor
Cutamesine, also called as SA4503, is an agonist, small-molecule ligand for the sigma-1 receptor with high selectivity currently in development to mediate neuroprotection and regeneration in the context of neurodegenerative disease. in vitro: reduced SOD1
Solid powder
1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine (11C)SA4503 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine dihydrochloride cutamesine SA 4503 SA-4503 SA4503
Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -58℃ for long term (months to years).
Shelf Life:
2 years
Boiling Point:
499.2±45.0 °C | Condition: Press: 760 Torr
1.053±0.06 g/cm3
Canonical SMILES:
1.Sertoli cell line lacks the immunoprotective properties associated with primary Sertoli cells.
Dufour JM;Dass B;Halley KR;Korbutt GS;Dixon DE;Rajotte RV Cell Transplant. 2008;17(5):525-34.
Sertoli cells are important for maintenance of the immune privileged environment of the testis and prolong survival of cotransplanted cells. The objective of the current study was to examine the immunoprotective properties of a mouse Sertoli cell line (MSC-1) in order to identify a Sertoli cell line that could be used to aid in investigation of the immunoprotective abilities of Sertoli cells. BALB/c islets were cotransplanted with 0-9 million primary BALB/c Sertoli cells or MSC-1 cells into diabetic C3H or BALB/c mice and protection of grafted islets was examined by monitoring blood glucose levels and immunohistochemical analysis. Additionally, expression of potential immunoprotective factors in MSC-1 cells was examined. Cotransplantation of islets with 3 million primary Sertoli cells significantly prolonged islet allograft survival (61.1 +/- 6.9 days; p < 0.05) compared with control mice that received allogeneic islets alone (26.9 +/- 2.1 days). Grafts collected from normoglycemic C3H mice at 100 days posttransplant contained insulin-positive beta-cells adjacent to allogeneic Sertoli cells arranged in tubule-like structures. In contrast, cotransplantation of islet allografts with MSC-1 cells did not prolong islet survival (average 29.
2.Evaluation of (+)-p-[11C]methylvesamicol for mapping sigma1 receptors: a comparison with [11C]SA4503.
Ishiwata K;Kawamura K;Yajima K;QingGeLeTu;Mori H;Shiba K Nucl Med Biol. 2006 May;33(4):543-8. Epub 2006 May 3.
Vesamicol is a leading compound for positron emission tomography (PET) and single photon emission computed tomography (SPECT) tracers for mapping the vesicular acetylcholine transporter (VAChT). Recently, we found that (+)-p-methylvesamicol ((+)-PMV) has low affinity for VAChT (K(i)=199 nM), but has moderate to high affinity for sigma receptors: K(i)=3.0 nM for sigma1 and K(i)=40.7 nM for sigma2, and that sigma1-selective SA4503 (K(i)=4.4 nM for sigma1 and K(i)=242 nM for sigma2) has moderate affinity for VAChT (K(i)=50.2 nM). In the present study, we examined the potential of (+)-[11C]PMV as a PET radioligand for mapping sigma1 receptors as compared with [11C]SA4503. In rat brain, similar regional distribution patterns of (+)-[11C]PMV and [11C]SA4503 were shown by tissue dissection and by ex vivo autoradiography. Blocking experiments using (+/-)-PMV, (-)-vesamicol, SA4503, haloperidol and (+/-)-pentazocine showed that the two tracers specifically bound to sigma1 receptors, and that [11C]SA4503 exhibited greater specific binding than (+)-[11C]PMV. No sign of VAChT-specific binding by [11C]SA4503 was observed in the striatum, which is rich in VAChT sites. In conclusion, (+)-[11C]PMV specifically bound to sigma1 receptors in the brain, but to a lesser extent than [11C]SA4503, suggesting that (+)-[11C]PMV is a less preferable PET ligand than [11C]SA4503.
3.Age-related changes of the binding of [3h]SA4503 to sigma1 receptors in the rat brain.
Ishiwata K;Kobayashi T;Kawamura K;Matsuno K Ann Nucl Med. 2003 Feb;17(1):73-7.
We have recently developed 1-([3-O-methyl-11C]3,4-dimethoxyphenethyl)-4-(3-phenylpropyl) piperazine ([11C]SA4503) as a selective radioligand for mapping sigma1 receptors in the brain by positron emission tomography (PET). In the present short communication we evaluated the age-related changes of the binding of this ligand to sigma1 receptors in Fisher-344 rats (1.5-, 6-, 12-, and 24-month-old) by the in vitro binding assay. We also measured the binding of [3H](+)-pentazocine to sigma1 receptors and the binding of [3H]1,3-di-O-tolylguanidine to sigma2 receptors, which are current standard methods. The specific binding of the three radioligands increased age-dependently. Both Kd and Bmax values of the 24-month-old rats for each radioligand were significantly higher than those of the young rats (1.5- and 6-month-old). The increased numbers of both sigma1 and sigma2 receptor subtypes in the aged rats compensate for the lowered affinity, and rather enhanced the radioligand-receptor binding. The results contrast strikingly with the age-dependent decrease in the dopaminergic, cholinergic and glutamatergic receptors that are reported to be correlated with the sigma receptors, and indicate that a PET study with [11C]SA4503 to evaluate the aging process in humans would be of great interest.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Sigma Receptor Products

S1RA Hydrochloride
(CAS: 1265917-14-3)

The hydrochloride salt form of S1RA which is a σ1 receptor antagonist that has been found to have potential effect in pain therapy. It is still under Phase II c...

CAS 165377-43-5 Cutamesine

(CAS: 165377-43-5)

Cutamesine, also called as SA4503, is an agonist, small-molecule ligand for the sigma-1 receptor with high selectivity currently in development to mediate neuro...

CAS 206996-13-6 BD1063 dhydrochloride

BD1063 dhydrochloride
(CAS: 206996-13-6)

BD1063 dhydrochloride is a potent and selective antagonist of sigma 1 receptor(Ki= 9.15 nM)with 50-fold more selective over sigma-2(Ki= 449 nM) and >100-fold mo...

CAS 97-39-2 DTG

(CAS: 97-39-2)

DTG has been found to be a σ-receptor agonist and is useful in studies of its interaction with dopamine drug.

CAS 149409-57-4 NE 100 hydrochloride

NE 100 hydrochloride
(CAS: 149409-57-4)

NE 100 hydrochloride is a σ1 receptor antagonist with IC50 value of 4.16 nM. It displays antipsychotic activity in vivo.

CAS 128-62-1 Noscapine

(CAS: 128-62-1)

Noscapine is a phthalideisoquinoline alkaloid derived from the opium poppy Papaver somniferum, with mild analgesic, antitussive, and potential antineoplastic ac...

CAS 138356-09-9 BD 1008 dihydrobromide

BD 1008 dihydrobromide
(CAS: 138356-09-9)

BD 1008 dihydrobromide is a potent and selective σ receptor antagonist displaying 4-fold selectivity for σ1 over σ2. BD-1008 attenuates the toxicity and stimula...

CAS 138847-85-5 PRE-084 Hydrochloride

PRE-084 Hydrochloride
(CAS: 138847-85-5)

PRE-084 Hydrochloride is a selective sigma-1 agonist (Ki values are 2.2 and 13091 nM for σ1 and σ2 receptors respectively). PRE-084 is selective for PCP recepto...

CAS 155054-42-5 N-[2-(Piperidinylamino)ethyl]-4-iodobenzamide

(CAS: 155054-42-5)

N-[2-(Piperidinylamino)ethyl]-4-iodobenzamide is a selective ligand belongs to benzamides, therapeutic agents for human prostate tumors sigma-1, which binds wit...

CAS 165377-44-6 SA-4503 dihydrochloride

SA-4503 dihydrochloride
(CAS: 165377-44-6)

SA-4503 is a potent sigma receptor agonist. SA-4503 may have effects on depressive symptoms such as agitation, loss of interest, and impaired cognition, which a...

CAS 138356-21-5 BD 1047 dihydrobromide

BD 1047 dihydrobromide
(CAS: 138356-21-5)

The dihydrobromide salt form of BD-1047, a selective σ1 receptor antagonist, has been found to have antipsychotic effect and could be probably used against schi...

CAS 362512-81-0 TC 1

TC 1
(CAS: 362512-81-0)

TC 1 is a high affinity σ1 receptor ligand with selectivity over σ2 receptors (Ki = 10 and 370 nM respectively). TC 1 exhibits low affinity for dopamine (DAT), ...

CAS 105565-55-7 BMY 14802 hydrochloride

BMY 14802 hydrochloride
(CAS: 105565-55-7)

BMY 14802 hydrochloride is a potent sigma receptor antagonist (IC50 = 112 nM) with weak affinity for 5-HT1A and α1 receptors. BMY 14802 is potentially used as a...

CAS 139652-01-0 4H-1-Benzopyran-4-one, 6-[[6-(4-hydroxy-1-piperidinyl)hexyl]oxy]-3-methyl-2-phenyl-

4H-1-Benzopyran-4-one, 6-[[6-(4-hydroxy-
(CAS: 139652-01-0)

Sigma-LIGAND-1, also called as NPC 16377, is a selective sigma receptor ligand developed for the treatment of neurological disorders and psychotic disorders in ...

CAS 201216-39-9 4-PPBP maleate

4-PPBP maleate
(CAS: 201216-39-9)

4-PPBP, a piperidine derivative, is a σ ligand and selective non-competitive antagonist at recombinant NR1a/2B NMDA receptors expressed in Xenopus oocytes. It i...

Siramesine hydrochloride
(CAS: 224177-60-0)

Siramesine hydrochloride is the hydrochloride salt form of Siramesine. Siramesine is a selective sigma-2 receptor agonist with a potent anticancer activity in v...

CAS 207455-21-8 L-693,403 maleate

L-693,403 maleate
(CAS: 207455-21-8)

L-693,403 maleate is the maleate salt of L-693,403, which is a sigma receptor-binding compound. It has excellent selectivity over the dopamine D2 receptor and b...

CAS 172907-03-8 PB 28 dihydrochloride

PB 28 dihydrochloride
(CAS: 172907-03-8)

PB 28 dihydrochloride is a high affinity σ2 receptor agonist. It displays antiproliferative and cytotoxic effects in SK-N-SH neuroblastoma and C6 glioma cells.

CAS 154130-99-1 PD 144418 oxalate

PD 144418 oxalate
(CAS: 154130-99-1)

PD 144418 oxalate is a very selective sigma 1 agent (Ki values are 0.08 and 1377 nM for σ1 and σ2 respectively), devoid of any significant affinity for other re...

CAS 359625-79-9 CYR-101

(CAS: 359625-79-9)

MIN-101, a novel cyclic amide derivative, is a 5-HT2A and sigma 2 receptor antagonist (Ki= 7.53 nM for 5-HT2A and 8.19 nM for sigma-2, respectively).

Chemical Structure

CAS 165377-43-5 Cutamesine

Quick Inquiry

Verification code

Featured Items