CUDC-101 - CAS 1012054-59-9
Catalog number:
1012054-59-9
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
COA:
Inquire
Targets:
HDAC
Description:
CUDC-101 is a multi-targeted, small-molecule inhibitor of histone deacetylase (HDAC), epidermal growth factor receptor tyrosine kinase (EGFR/ErbB1), and human epidermal growth factor receptor 2 tyrosine kinase (HER2/neu or ErbB2) with potential antineoplastic activity. HDAC/EGFR/HER2 inhibitor CUDC-101 inhibits the activity of these three enzymes but the exact mechanism of action is presently unknown. This agent may help overcome resistance to inhibition of EGFR and Her2 through a simultaneous, synergistic inhibition of EGFR, Her2, and HDAC.
Publictions citing BOC Sciences Products
  • >> More
Synonyms:
CUDC-101
MSDS:
Inquire
Current Developer:
Curis Inc.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related HDAC Products


CAS 112522-64-2 Tacedinaline

Tacedinaline
(CAS: 112522-64-2)

Tacedinaline, also known as CI-944, is an orally bioavailable substituted benzamide derivative with potential antineoplastic activity. Tacedinaline inhibits his...

NCC-149
(CAS: 1316652-41-1)

NCC149 is a potent and selective histone deacetylase 8 (HDAC8) inhibitor.

CAS 1045792-66-2 CAY10603

CAY10603
(CAS: 1045792-66-2)

CAY10603 is a potent and selective inhibitor of HDAC6 with IC50 of 2 pM, as compared with 271, 252, 0.42, 6851, and 90.7 nM for HDAC1, 2, 3, 8, and 10, respecti...

MI-192
(CAS: 1415340-63-4)

MI-192 is a selectively histone deacetylases inhibitor (HDACs) that preferentially inhibits HDAC2 with IC50 value of 30 nM and HDAC3 with IC50 value of 16 nM ov...

CAS 726169-73-9 Mocetinostat

Mocetinostat
(CAS: 726169-73-9)

Mocetinostat is a rationally designed, orally available, Class 1-selective, small molecule, 2-aminobenzamide HDAC inhibitor with potential antineoplastic activi...

CAS 1187075-34-8 Resminostat hydrochloride

Resminostat hydrochloride
(CAS: 1187075-34-8)

Resminostat is an inhibitor of histone deacetylase (HDAC) with IC50 values of 42.5nM, 50.1nM and 71.8nM, respectively against HDAC1, 3 and 6. As an inhibitor of...

UF010
(CAS: 537672-41-6)

UF-010 is a Class I HDAC inhibitor, inhibiting proliferation of a range of cancer cell lines.

CAS 848354-66-5 PTACH

PTACH
(CAS: 848354-66-5)

PTACH is a SAHA-based novel inhibitor of histone deacetylase (HDAC). It exerts potent growth inhibition against various human cancer cells, with EC50 values ran...

CAS 783355-60-2 Abexinostat

Abexinostat
(CAS: 783355-60-2)

Abexinostat, also known as PCI-24781 or CRA-024781, is novel, broad-spectrum hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antine...

CAS 99873-43-5 Droxinostat

Droxinostat
(CAS: 99873-43-5)

Droxinostat is a selective inhibitor of HDAC3, HDAC6, and HDAC8. Droxinostat shows comparable inhibition of HDAC6 and HDAC8 (IC50 = 2.47 and 1.46 μmol/L, respec...

CAS 1215493-56-3 RG2833

RG2833
(CAS: 1215493-56-3)

RGFP 109 is a histone deacetylase (HDAC) inhibitor that has shown to reverse FXN gene silencing in short-term studies of Friedreich ataxia (FRDA) patient cells.

CAS 251456-60-7 M344

M344
(CAS: 251456-60-7)

M344 is a potent HDAC inhibitor, which can also induced expression of the pro-apoptotic genes, Puma and Bax, together with the morphological features of apoptos...

CAS 410536-97-9 Sirtinol

Sirtinol
(CAS: 410536-97-9)

Sirtinol is a SIRT inhibitor. Sirtinol significantly increased the acetylation of p53, which has been reported to be a target of SIRT1/2. Sirtinol significantly...

CAS 497833-27-9 Givinostat

Givinostat
(CAS: 497833-27-9)

Givinostat (INN) or gavinostat, aslo known as ITF2357,  is a histone deacetylase inhibitor with potential anti-inflammatory, anti-angiogenic, and antineoplastic...

CAS 910462-43-0 4SC-202

4SC-202
(CAS: 910462-43-0)

4SC-202 is a selective and potent, orallly available inhibitor of histone deacetylases (HDAC) specific for class 1 HDAC isoenzymes, with IC50 of 1.20 μM, 1.12 μ...

CAS 156-54-7 Sodium butyrate

Sodium butyrate
(CAS: 156-54-7)

Sodium butyrate is the sodium salt of butyric acid, used in the culture of mammalian cells.

Tinostamustine Hydrochloride
(CAS: 1793059-58-1)

The hydrochloride salt form of Tinostamustine, a benzimidazol derivative, has been found to be a HDAC inhibitor and could probably be effective against sorts of...

CAS 937039-45-7 TC-H 106

TC-H 106
(CAS: 937039-45-7)

TC-H 106 is a slow, tight-binding inhibitor of class I HDAC, including HDAC 1, 2, and 3 with IC50 values of 150 nM , 760nM, and 370 nM, respectively. It demonst...

CAS 209783-80-2 MS-275 (Entinostat)

MS-275 (Entinostat)
(CAS: 209783-80-2)

CAS 1716-12-7 Sodium Phenylbutyrate

Sodium Phenylbutyrate
(CAS: 1716-12-7)

Phenylbutyrate is a well-known HDAC inhibitor, which increases gene transcription of a number of genes, and also exerts neuroprotective effects.

Chemical Structure

CAS 1012054-59-9 CUDC-101

Quick Inquiry

Verification code

Featured Items