CS-0777-P - CAS 840523-39-9
Catalog number: 840523-39-9
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C21H31N2O5P
Molecular Weight:
422.45
COA:
Inquire
Targets:
Sphingosine 1 Phosphate Receptor
Description:
CS-0777 is a selective sphingosine 1-phosphate receptor modulator agonist. It is in clinical trials for the treatment of multiple sclerosis, but no recent development was reported.
Purity:
98%
Appearance:
Powder
Synonyms:
CS-0777; CS0777; CS 0777. 1-(5-((3R)-3-amino-3-methyl-4-(phosphonooxy)butyl)-1-methyl-1H-pyrrol-2-yl)-4-(4-methylphenyl)-1-Butanone
Solubility:
Soluble in DMSO
Storage:
-20℃ Freezer
MSDS:
Inquire
Application:
Multiple sclerosis
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
InChIKey:
SFFJDCSCTWIGSG-OAQYLSRUSA-N
InChI:
1S/C21H31N2O5P/c1-16-7-9-17(10-8-16)5-4-6-20(24)19-12-11-18(23(19)3)13-14-21(2,22)15-28-29(25,26)27/h7-12H,4-6,13-15,22H2,1-3H3,(H2,25,26,27)/t21-/m1/s1
Canonical SMILES:
Cc1ccc(CCCC(=O)c2ccc(CC[C@@](C)(N)COP(=O)(O)O)n2C)cc1
Current Developer:
Originator Daiichi Sankyo Company
1.Discovery of CS-0777: A Potent, Selective, and Orally Active S1P1 Agonist.
Nishi T1, Miyazaki S1, Takemoto T1, Suzuki K1, Iio Y1, Nakajima K1, Ohnuki T1, Kawase Y1, Nara F1, Inaba S1, Izumi T1, Yuita H2, Oshima K2, Doi H2, Inoue R2, Tomisato W2, Kagari T2, Shimozato T2. ACS Med Chem Lett. 2011 Mar 2;2(5):368-72. doi: 10.1021/ml100301k. eCollection 2011.
CS-0777 (3) is phosphorylated in vivo, and the phosphate of CS-0777 (CS-0777-P) (4) acts as a selective S1P receptor-1 (S1P1) modulator. We report herein the synthesis of CS-0777 and CS-0777-P, pharmacological effects such as S1P1 and S1P3 agonist activity in vitro, peripheral blood lymphocyte lowering effects and the suppressive effect on experimental autoimmune encephalomyelitis (EAE), and also the pharmacokinetics in rats. CS-0777-P had ∼320-fold greater agonist activity for human S1P1 (EC50; 1.1 nM) relative to S1P3 (EC50; 350 nM). Following administration of single oral doses of 0.1 and 1 mg/kg of CS-0777 in rats, lymphocyte counts decreased significantly, with a nadir at 12 h postdose and recovery to vehicle control levels by 5 days postdose. In the EAE model compared to the vehicle-treated group, significant decreases in the cumulative EAE scores were observed for the 0.1 and 1 mg/kg CS-0777 groups in rats. CS-0777 is currently in clinical trials for the treatment of multiple sclerosis (MS).
2.Identification of a metabolizing enzyme in human kidney by proteomic correlation profiling.
Sakurai H1, Kubota K, Inaba S, Takanaka K, Shinagawa A. Mol Cell Proteomics. 2013 Aug;12(8):2313-23. doi: 10.1074/mcp.M112.023853. Epub 2013 May 14.
Molecular identification of endogenous enzymes and biologically active substances from complex biological sources remains a challenging task, and although traditional biochemical purification is sometimes regarded as outdated, it remains one of the most powerful methodologies for this purpose. While biochemical purification usually requires large amounts of starting material and many separation steps, we developed an advanced method named "proteomic correlation profiling" in our previous study. In proteomic correlation profiling, we first fractionated biological material by column chromatography, and then calculated each protein's correlation coefficient between the enzyme activity profile and protein abundance profile determined by proteomics technology toward fractions. Thereafter, we could choose possible candidates for the enzyme among proteins with a high correlation value by domain predictions using informatics tools. Ultimately, this streamlined procedure requires fewer purification steps and reduces starting materials dramatically due to low required purity compared with conventional approaches.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Sphingosine 1 Phosphate Receptor Products


BMS-520
(CAS: 1236188-38-7)

This active molecular is a selective S1P1 receptor agonist that originated by Bristol-Myers Squibb. BMS-520 shows really good efficacy in animal models of arthr...

CAS 1202073-26-4 AMG 369

AMG 369
(CAS: 1202073-26-4)

This active molecular is a S1P1/S1P5 agonist with limited activity at S1P3. AMG 369 has no activity at S1P2 and S1P4. AMG-369 is shown to reduce blood lymphocyt...

CAS 1306760-87-1 Ozanimod

Ozanimod
(CAS: 1306760-87-1)

Ozanimod, also known as RPC1063, is a selective oral S1P Receptor 1 modulator.

CAS 840523-39-9 CS-0777-P

CS-0777-P
(CAS: 840523-39-9)

CS-0777 is a selective sphingosine 1-phosphate receptor modulator agonist. It is in clinical trials for the treatment of multiple sclerosis, but no recent devel...

CYM 50358 hydrochloride

The hydrochloride salt form of CYM 50358, which has been found to be an effective S1P4 antagonist.

APD334
(CAS: 1206123-37-6)

This active moleclar is a Sphingosine 1 Phosphate Receptor antagonists for treatment of multiple sclerosis (MS) and other autoimmune diseases originated by Aren...

PF-543 hydrochloride
(CAS: 1706522-79-3)

The hydrochloride salt form of PF-543, a novel SphK1 inhibitor that could exhibit activity in induceing necrosis in human colorectal cancer cells in biological ...

CAS 1345858-76-5 CYM 50308

CYM 50308
(CAS: 1345858-76-5)

CYM 50308 has been found to be an effective and selective S1P4 agonist.

Chemical Structure

CAS 840523-39-9 CS-0777-P

Quick Inquiry

Verification code

Featured Items