Crizotinib - CAS 877399-52-5
Catalog number:
877399-52-5
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C21H22Cl2FN5O
Molecular Weight:
450.343
COA:
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Targets:
c-Met/HGFR
Description:
Crizotinib is an anti-cancer drug acting as an ALK (anaplastic lymphoma kinase) and ROS1 (c-ros oncogene 1) inhibitor.
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Purity:
>98%
Synonyms:
PF-02341066
MSDS:
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1.Central nervous system involvement in ALK-rearranged NSCLC: promising strategies to overcome crizotinib resistance.
Russo A1, Franchina T1, Ricciardi GR1, Ferraro G1, Scimone A1, Bronte G2, Russo A2, Rolfo C3, Adamo V1. Expert Rev Anticancer Ther. 2016 Apr 23. [Epub ahead of print]
ALK rearranged Non Small Cell Lung Cancers (NSCLCs) represent a distinct subgroup of patients with peculiar clinic-pathological features. These patients exhibit dramatic responses when treated with the ALK tyrosine kinase inhibitor Crizotinib, albeit Central Nervous System (CNS) activity is much less impressive than that observed against extracranial lesions. CNS involvement has become increasingly observed in these patients, given their prolonged survival. Several novel generation ALK inhibitors have been developing to increase CNS penetration and to provide more complete ALK inhibition. The CNS activity of Crizotinib and novel generation ALK inhibitors will be summarized in this review, evaluating the strengths and weaknesses of the therapeutic strategies developed to date in this specific subgroup of NSCLCs with a look towards the future.
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CAS 877399-52-5 Crizotinib

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