|Description||Crenolanib is an orally bioavailable small molecule, targeting the platelet-derived growth factor receptor (PDGFR), with potential antineoplastic activity. Crenolanib binds to and inhibits PDGFR, which may result in the inhibition of PDGFR-related signal transduction pathways, and, so, the inhibition of tumor angiogenesis and tumor cell proliferation. PDGFR, up-regulated in many tumor cell types, is a receptor tyrosine kinase essential to cell migration and the development of the microvasculature.|
|Synonyms||CP 868596; CP868596; CP-868596; ARO 002; RO-002; RO002; Crenolanib.|
|Current Developer||AROG Pharmaceuticals, LLC.|
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