CRANAD 2 - CAS 1193447-34-5
Catalog number: 1193447-34-5
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C23H25BF2N2O2
Molecular Weight:
410.26
COA:
Inquire
Targets:
Amyloid-β
Description:
CRANAD 2, a difluoroboron-derivatized curcumins, is a near-infrared (NIR) Aβ plaque-specific fluorescent probe. It penetrates the blood-brain barrier and shows a high affinity for Abeta aggregates (K(d) = 38.0 nM).
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Brife Description:
Near-infrared probe that detects Aβ40 aggregates
Appearance:
Black solid
Synonyms:
[4-[2-[6-[(E)-2-[4-(dimethylamino)phenyl]ethenyl]-2,2-difluoro-1,3-dioxa-2-boranuidacyclohex-5-en-4-ylidene]ethylidene]cyclohexa-2,5-dien-1-ylidene]-dimethylazanium; CRANAD-2; AOB1744; ZINC215806197; CRANAD 2
Solubility:
Soluble to 5 mM in DMSO with gentle warming
Storage:
Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -35℃ for long term (months to years).
MSDS:
Inquire
Application:
Implicated in Alzheimer's disease
InChIKey:
PVXQJYXODFZTBR-UHFFFAOYSA-N
InChI:
1S/C23H25BF2N2O2/c1-27(2)20-11-5-18(6-12-20)9-15-22-17-23(30-24(25,26)29-22)16-10-19-7-13-21(14-8-19)28(3)4/h5-17H,1-4H3
Canonical SMILES:
[B-]1(OC(=CC(=CC=C2C=CC(=[N+](C)C)C=C2)O1)C=CC3=CC=C(C=C3)N(C)C)(F)F
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