CPI-1205 - CAS 1621862-70-1
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C27H33F3N4O3
Molecular Weight:
518.57
COA:
Inquire
Targets:
HMTase
Description:
A highly potent and selective EZH2 inhibitor (biochemical IC50=2 nM, cellular EC50=32 nM)
Publictions citing BOC Sciences Products
  • >> More
Synonyms:
N-[(4-methoxy-6-methyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-1-[(1R)-1-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]ethyl]indole-3-carboxamide; (R)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide; CPI-1205
Solubility:
DMSO
Storage:
Store in a cool and dry place (or refer to the Certificate of Analysis).
MSDS:
Inquire
Boiling Point:
692.5±55.0 ℃ at 760 Torr
Density:
1.31±0.1 g/cm3
InChIKey:
HPODOLXTMDHLLC-QGZVFWFLSA-N
InChI:
1S/C27H33F3N4O3/c1-16-13-23(37-4)21(25(35)32-16)14-31-26(36)24-18(3)34(22-8-6-5-7-20(22)24)17(2)19-9-11-33(12-10-19)15-27(28,29)30/h5-8,13,17,19H,9-12,14-15H2,1-4H3,(H,31,36)(H,32,35)/t17-/m1/s1
Canonical SMILES:
CC1=CC(=C(C(=O)N1)CNC(=O)C2=C(N(C3=CC=CC=C32)C(C)C4CCN(CC4)CC(F)(F)F)C)OC
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related HMTase Products


CAS 1338466-77-5 EPZ004777

EPZ004777
(CAS: 1338466-77-5)

EPZ004777 is a potent, selective inhibitor of DOT1L. Treatment of mixed lineage leukemia (MLL) cells with EPZ004777 selectively inhibits H3K79 methylation ...

CAS 1238673-32-9 UNC0321

UNC0321
(CAS: 1238673-32-9)

UNC0321 is the first G9a inhibitor with picomolar potency and the most potent G9a inhibitor to date. Protein lysine methyltransferase G9a, which catalyzes methy...

CAS 1255580-76-7 UNC-0638

UNC-0638
(CAS: 1255580-76-7)

UNC0638 is an inhibitor of G9a and GLP with excellent potency and selectivity over a wide range of epigenetic and non-epigenetic targets. UNC0638 treatment of a...

SGC2085 HCl
(CAS: 1821908-49-9)

SGC2085, also called as GTPL9259, is a potent and selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor with an IC50 of 50 nM and more...

XY1
(CAS: 1624117-53-8)

XY1 is a close analog of SGC707 that is completely inactive against PRMT3 at concentrations as high as 100 µM. It is intended to be used as a negative control f...

CAS 1561178-17-3 SGC 0946

SGC 0946
(CAS: 1561178-17-3)

SGC0946 is a potent and selective inhibitor of DOT1L, which potently and selectively kills cells containing an MLL translocation. SGC0946 inhibits DOT1L with an...

CAS 1620401-82-2 UNC0379

UNC0379
(CAS: 1620401-82-2)

UNC0379 is a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8. UNC0379 is active in multiple biochemical assays. Its affinity t...

CAS 1906920-28-2 BAY-598 R-isomer

BAY-598 R-isomer
(CAS: 1906920-28-2)

BAY-598 R-isomer is the R-isomer of BAY589 which is a potent, peptide-competitive chemical probe for SET and MYND domain-containing protein 2 (SMYD2), IC50 valu...

CAS 1793053-37-8 LLY-507

LLY-507
(CAS: 1793053-37-8)

LLY-507, a lysine N-methyltransferase, is a cell-active, small molecule, and selective inhibitor of Protein-lysine Methyltransferase SMYD2 (IC50 = 15 nM), with ...

CAS 1621862-70-1 CPI-1205

CPI-1205
(CAS: 1621862-70-1)

A highly potent and selective EZH2 inhibitor (biochemical IC50=2 nM, cellular EC50=32 nM)

CAS 1271738-62-5 MI-2

MI-2
(CAS: 1271738-62-5)

MI-2 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 446 nM.

CAS 432529-82-3 BCI-121

BCI-121
(CAS: 432529-82-3)

BCI-121, a SMYD3 inhibitor, induces a significant reduction in SMYD3 activity both in vitro and in CRC cells.

CAS 1627676-59-8 PFI-2

PFI-2
(CAS: 1627676-59-8)

PFI-2 is a potent, selective, and cell-active lysine methyltransferase SETD7 inhibitor with Ki (app) and IC50 of 0.33 nM and 2 nM, 1000-fold selectivity over ot...

CAS 1857417-13-0 MI-503

MI-503
(CAS: 1857417-13-0)

MI-503 is a potent, selective and orally bioavailable Menin-MLL inhibitor (IC50= 14.7 nM). It is used in the pharmacological inhibition of menin-MLL interaction...

CAS 1417329-24-8 MM-102

MM-102
(CAS: 1417329-24-8)

MM-102, as a MLL1 mimetic, shows high binding affinities to WDR5 with IC50 of 2.9 nM and Ki of < 1 nM.

PFI-2 hydrochloride
(CAS: 1627607-87-7)

PFI-2 hydrochloride is a potent, cell-permeable inhibitor of SET7/9 (IC50 = 2 nM) and is approximately 1,000-fold selective over a panel of 18 other methyltrans...

CAS 1271738-59-0 MI-3

MI-3
(CAS: 1271738-59-0)

MI-3 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 648 nM.

MS023
(CAS: 1831110-54-3)

MS023 is a Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases. MS023 displayed high potency for type I PRMTs inclu...

CAS 1320288-17-2 UNC0646

UNC0646
(CAS: 1320288-17-2)

UNC-0646 is a novel G9a inhibitor with excellent potency in a variety of cell lines and excellent separation of functional potency versus cell toxicity.

HLCL-61 hydrochloride
(CAS: 1158279-20-9)

The hydrochloride salt form of HLCL-61, an effective inhibitor of PRMT5, could probably useful in the treatment of acute myeloid leukemia.

Chemical Structure

CAS 1621862-70-1 CPI-1205

Quick Inquiry

Verification code

Featured Items